IC-ICP/MS – with Metrohm Coupling of Metrohm ion chromatography and mass spectrometry with inductively coupled plasma Take advantage of the benefits of IC-ICP/MS with Metrohm ion chromatographs Is the determination of individual species more important 02 Combining ion chromatography and mass spectrometry to you than the total content, for instance the distinction with inductively coupled plasma (IC-ICP/MS) is the between chromium III and chromium VI? Do you need to method of choice for such analytical challenges: work in compliance with the standards and, say, deter-mine bromate according to the EPA method 321.8? • With the selectivity of ion chromatography, you separate ionic analytes by their chemical structure and binding properties. • Then, due to the element-specific selectivity and high sensitivity of ICP/MS detection, you achieve the lowest detection limits. The advantages of IC-ICP/MS • Correct assessment of toxicity of samples • Lowest detection limits 03 If you want to assess the toxicity of a sample cor-With an ICP/MS, you can connect a high-sensitivity rectly, knowing the total content of the element detector in series to the traditional ion chromato-concerned as a sum parameter does not help. Health graphy detectors (conductivity, UV/VIS, or ampero-hazards often arise from the presence of a particular metry). This can significantly increase the sensitivity species, which is why only the selectivity and high of your analytics. sensitivity of IC-ICP/MS allow an accurate assessment. • Convenient operation with only one software Metrohm ion chromatographs coupled with ICP/MS • Prevention of matrix effects (e.g., Metrohm IC + Perkin Elmer ICP/MS) can be Interfering sample components can be separated by con trolled with EmpowerTM 3, Waters' world-leading means of automatic sample preparation and custom chromatography data software (CDS). With chromatographic conditions, so that matrix effects EmpowerTM 3, you benefit from excellent compliance are prevented. and traceability of your data as well as comprehen-sive security features and audit trails. Please note: In general, Metrohm ion chromatographs can be coupled with ICP/MS devices from all manufacturers! Speciation of arsenic in rice, column: Metrosep Carb 2 - 250/2.0, gradient eluent A: 4 mmol/L ammonium bicarbonate, eluent B: 4 mmol/L ammonium bicarbonate + 40 mmol/L ammonium nitrate, pH 8.6; column temperature: 40 °C; sample volume: 20 µL; fl ow rate: 0.2 mL/min; plasma output: 1550 W; plasma gas fl ow: 17 L/min; auxiliary gas fl ow: 1 L/min; nebulizer gas fl ow: 0.94 L/min; integration time: 0.1 s (Source: Use of the IC-ICP-MS and IC-ESI-MS coupling for the anion-chromatographic elemental species analysis of arsenic, bachelor thesis by Lukas Bischof, Marburg 2017) For further application examples please refer to white paper WP-008 at www.metrohm.com Why ion chromatography from Metrohm? Easy to use, extremely robust, highest measuring sensitivity, and incomparable service and support – that's Metrohm ion chromatography. You will also benefit from these advantages: • Automatic sample preparation techniques (e.g., Inline Ultrafiltration, Inline Dialysis, etc.) for more user convenience, time savings, and reproducible results • Metal-free flow path – no risk of contamination when determining ultratraces and transition metals • Robust and reliable hardware ensures maximum instrument availability, especially during routine operation • Intelligent monitoring of all system parameters with warning and intervention limits prevents incorrect operation • Premium Swiss quality – 3-year instrument warranty and 10-year warranty on the anion suppressor G, CH-9100 Herisau ohm A witzerland by Metr www.metrohm.com , printed in S SW Subject to change Design by Ecknauer+Schoch A 8.000.5241EN – 2018-08