NIRS Analyzer Pro Nondestructive inline process analysis based on high-resolution diode array technology. Features and Benefits 02 • High resolution diode array technology for accurate and continuous analysis in reflectance or transflectance mode • Quick and simple implementation of the analyzer • Easily transfer models between NIRS Analyzer Pro systems • Uptime protection with dual lamp technology for low maintenance, provides seamless accuracy when automatically switched to the pre-standardized second lamp • Dedicated sample interfaces provide accuracy and rapid implementation • Instant measurement of complete wavelength range for direct measurement of liquids and solids, also suitable for fast moving, uneven samples • Quantitative and qualitative data for better inline process control • Vision software is available in a fully validatable pharmaceutical version which is FDA 21 CFR Part 11 compliant • Fulfills the regulations of the Process Analytical Technology (PAT) initiative of the FDA as well as Quality by Design (QbD) tenets • Integrated diagnostics with Metrohm calibration tool, Vision enables simple and reliable calibration setup • Metrohm supports several interfaces for integration to local control systems, enabling automatic regulation of the process NIRS Analyzer Pro is a process analysis system based on The solution helps to optimize the use of raw materials 03 high re so lution diode array technology. It provides non-and to consistently run production closer to target spe ci-destructive analysis of liquids, granules, powders, slurries fi cations. For pharmaceutical manufacturers, the NIRS or opaque samples directly in the process line without Analyzer Pro is a valuable PAT tool, allowing you to in - by pass – a true inline system. crease throughput and maximize on QbD (Quality by De sign). The Vision software is also available in a fully The analyzer can be housed in a robust cabinet mounted vali datable pharmaceutical version which is FDA 21 CFR at the relevant location in the production area. Measure- Part 11 compliant. ments are displayed in the control room and results can be fed into a regulation system for closed-loop automa tic Precise instrument matching enhances method develop-control. ment, minimizes implementation efforts and ensures ca - lib ration model transferability between analyzers. System Description The NIRS Analyzer Pro process analyzer is available with The complete wavelength range (1100–1650 nm) is dedicated interfaces based on reflectance or transflec-mea sured instantaneously, which also enables highly tance tech nology whichever is best suited for each app- ac curate measurements on fast moving sam ples. Calib ra-lication area. Mea surements are done directly on the mo - tions are transferable between units ensuring easy ex - ving sample in the process stream. A high-intensity dual pan sion to other measure ment points. Integration to pro-lamp light source illuminates the sample directly or cess regulations systems can be done through multiple through an optical fiber. The light interacts with the interfaces. sample and the reflected or transmitted light is measured by the diode array sensor. The pre-standardized lamps in the dual lamp system secure uptime and analytical accuracy remains unchanged even after switching to a new lamp. Lamp switching is done automatically without any need for operator intervention. Dedicated sample interfaces Window reflectance (Contact Reflection) 04 Temperature Max 150 °C (302 °F) Inline analysis of solids, granulates, powders, and other Pressure Max Vacuum > 1 torr (0.02 PSI) similar products in pipes or transport systems without Max Pressure < 3000 PSI bypass can be performed. The products pass over the in - Lens Sapphire; Diameter 45 mm, ter face window. The window reflection interface can thickness 12 mm, easily be installed into the production line using standard with high quality industry flowcells or welding an interface flange into the EPDM O-ring seal wall of the pipe/transport system. The analyzer can be set up to scan through a process window if absolutely no contact with the process is allowed. Direct light (Non-Contact) Lens Sapphire; Diameter 45 mm, Inline analysis of products where direct contact with the thickness 12 mm, product is not a technically feasible solution i.e. product with high quality transported on a conveyer belt. Uneven surfaces are able EPDM O-ring seal to be analyzed easily, such as in the determination of tree Distance 100–250 mm to sample surface species in the pulp and paper industry or sorting fiber Scanning area 20–85 mm Ø blends in the textile industry. Transflectance measurements (Fiber System) Material SS 316L, Hastelloy, 05 Inline analysis of clear to scattering liquids and slurries Other materials also available (less than 15% solids) is possible using the properties Diameter Customizable, from of transflectance and the micro interactance immersion 12.7 mm (0.5 in) probe. The probe consists of a probe body and an ad just-Length Customizable, from able high-energy mirror tip. The sample flows through 305 mm (12 in) the gap between the probe body and mirror tip, and Optical Fiber Microbundle ultra-low OH fiber adjusting the mirror tip defines the pathlength (equal (maximum 75 meters) to two times the gap) for analysis. This probe can be Temperature Max 120 °C (248 °F) instal ed directly into the process line or reactor, or into Pressure Max Pressure < 5000 PSI a side-stream loop. Fixed pathlength immersion probes Installation Compression fitting, are also available. Welded flange, Other options also available Reflectance of powders (Fiber System) Material SS 316L, Teflon (PTFE), Hastelloy, Inline analysis of fine powder, such as in the manufacture Other materials also available of pharmaceuticals, can be performed with the micro Diameter 25.4 mm (1 in) in teractance reflectance probe with purge on collection Length Customizable, from tip (powder probe). The powder probe interface can eas-305 mm (12 in) ily be installed into a hopper, fluid bed dryer, reactor, or Optical Fiber Microbundle ultra-low OH fiber pipe with free falling product. The powder collects at the (maximum 75 meters) end of the probe for analysis. The probe has no moving Purging Clean compressed air 43–72 PSI, parts and is automatically cleaned with compressed air or or Nitrogen nitrogen prior to each analysis. Additionally, the powder Temperature Max 120 °C (248 °F) probe can be created from Teflon in the case of sticky Installation Compression fitting, powders. Welded flange, Other options also available Other Fiber Probes An assortment of reflectance probes is available for other • Micro Interactance Reflectance Probe types of samples and process situations. The sizes and • Optimized Micro Reflectance (45 degree) Probe materials can be changed depending on the process and requirements. Standards and approvals NIRS Analyzer Pro is CE labeled and complies with the following directives: 06 • Low Voltage Directive (LVD) (2006/95/EC) • RoHS Directive (2002/95/EC) • Packaging and packing and waste Directive (94/62/EC) • WEEE Directive (2002/96/EC) • IECEx, Zone 20 (IEC 61241-1-2004 – Explosion safety for DUST-Protection by enclosure tD) • REACH Directive (1907/2006/EC) • Developed and produced according to Metrohm ISO approval ISO 9001 Technical Specifications NIRS Analyzer Pro Reflection 07 Analysis time 5–50 ms / integration time; Average time per result 1–15 seconds Measurement mode Reflectance (Window reflectance; Direct Light, Powder Probe) Wavelength range 1100–1650 nm Detector InGaAs Diode array Spectral dispersion 1.1 nm / pixel NIRS Analyzer Pro Transflectance Analysis time 5–50 ms / integration time; Average time per result 1–15 seconds Measurement mode Transflectance (Immersion Probe) Wavelength range 1100–1650 nm Detector InGaAs Diode array Spectral dispersion 1.1 nm / pixel General (Typical performance under normal operating conditions) Light source lifetime Dual lamp system MTBF = 17’500 h Software package Vision for instrument control and method development Fully validatable pharmaceutical version is FDA 21 CFR Part 11 compliant Wavelength accuracy 0.5 nm Wavelength precision < 0.02 nm Wavelength stability < 0.01 nm/°C Noise < 60 micro AU Random Vibrations 0.4 grms at 10–150 Hz according to IEC 60068-2-64 0.4 grms at 10–1250 Hz according to Metrohm internal standard (more information available on request) Temperature -5–40 °C (23–104 °F). With purge -5–65 °C (23–149 °F) Purge air Flow rate minimum 5 L/min, > 99.99% water free, > 99.9% free of oil and fine particles down to 0.3 μm Ambient humidity 10–90% relative (non-condensing) Dimensions (w × h × d) 42 × 42 × 13.5 cm (16.5 × 16.5 × 5.3 inches) + brackets to hold the unit Weight 25 kg / 55 lbs Cabinet 1.5 mm (lid 2.5 mm) Stainless Steel EN 1.4301 (SS2333) Protection IP69K1) according to IEC 60529 and DIN 40050 part 9, NT ELEC 023 Communication 4–20 mA, OPC, Modbus, Profibus Power supply Recommended isolated or conditioned line power 100–240 VAC, 50–60 Hz, 2.0 A, 150 W 1) IP6x is the highest protection for dust entering the unit. IPx9K means protected against the effect of high-pressure water and/or steam cleaning at high temperature. www.metrohm.com G, CH-9100 Herisau ohm A witzerland by Metr , printed in S SW Subject to modifications Layout by Ecknauer+Schoch A 8.928.5000EN – 2016-05