Reclassification of Imidazole

The European Chemicals Agency (ECHA) has changed the classification of one of the main components of the Karl Fischer reagents.

After the end of the transitional phase (till 2015), Karl Fischer reagents containing imidazole must be labelled with the following pictogram and warning.

GHS08 (health risk)

H360D (may harm the unborn child)

How dangerous are Karl Fischer reagents How can contact with Karl Fischer reagents be contain ing imidazole?

avoided?

Imidazole has not become more dangerous. There has Metrohm Karl Fischer titrators offer a variety of techni-also been no change in the composition of the Karl Fischer cal functions which prevent direct contact with the Karl reagents.

Fischer reagents, thus ensuring safety at work.

Nevertheless, a new study has shown that an intake of • Automatic reagent change: The titration vessel can 180 mg per kg per day can harm the unborn child.

be emptied and refilled with fresh reagent by using the Dosino and the dosage unit. It is not necessary to How much imidazole is contained in a bottle of open the titration vessel.

Karl Fischer reagent?

• Ti stand with integrated pump: With the 803

A person weighing 60 kg would have to consume ca. 10 g stand, you can exchange the reagents with a single imidazole by mouth daily. Depending on the reagent, this touch of a button.

corresponds to about 100 mL to 1’000 mL.

• Overflow protection: The overflow protection And how much in a titration vessel?

6.1623.000 prevents overflow from the waste bottle.

There is normally between 30 and 150 mL reagent in • Stop volume during conditioning: Conditioning a Karl Fischer titration vessel. This means that the user is broken off after addition of a defined volume, even would have to drink the contents of a whole titration with very «wet» solvents. There can be no overflow vessel to reach the critical level for imidazole from the titration vessel.

www.metrohm.com

8.000.5061EN – 2012-03

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