901 Titrando Intelligent Karl Fischer titrator Water determination in the modern titration laboratory 02 03 Highlights • The Magic Touch – Favorites for quick titration start • iConnect – mobile measuring input with digital data transfer • iTrodes – intelligent sensors for automatic electrode recognition • Intelligent dosing elements • Karl Fischer and SET titration • Sample Processor control • Client-server database with tiamo TM • Parallel titration with tiamo TM • Liquid handling with the patented Dosino • Complies with GMP/GLP and FDA Regulations such as 21 CFR Part 11 • USB interfaces for sample changer, printer, PC keyboard, barcode reader ... • Wireless communication via Bluetooth for printer and balance Water determination with the Titrando 04 Karl Fischer titration with the Titrando Karl Fischer water determination is one of the most fre-quently applied laboratory methods. In contrast to other water determination methods it is specific, fast, and requires no expensive equipment. With an application range of 0.1% to 100% water volumetric Karl Fischer titration is used in a wide variety of fields. No matter whether you determine the water content in food, cos-metics or pharmaceutical products, the Titrando is always the right instrument. The KF mode excels with easy and intuitive user guidance. Just one example: The KF icons show you at a glance whether the instrument is still busy conditioning or whether you can start the water determination. The electrode test and the parameter «safety stop» prevent cell from runningover during conditioning. If, for example, the electrode is not connected correctly or the titration cell is very humid, conditioning is stopped after a given time or a given volume of KF reagent added. This feature increases work safety in your laboratory. The 803 KF Titration Stand Use the 803 KF Titration Stand for stirring and manually exchanging the spent titration vessel contents. With the integrated membrane pump, solvent can be aspirated or added without the cell having to be opened. This trans-lates into vastly reduced conditioning times and prevents direct contact with Karl Fischer reagents. Automatic reagent change – so very easy! Just as comfortable is the automatic reagent change with the Dosino dosing system. You define the point of time and the instrument carries out the change fully automatically. 05 Reagent dosing à la carte 06 Titrating means dosing intelligently. The Titrando System ers, any reagent bottle can be used directly. The Dosino gives you the choice. With the 901 Titrando you dose houses the latest state-of-the-art electronics and micro-with Dosinos and Dosing Units that are mounted directly mechanics. The Dosing Unit can be exchanged within onto the reagent bottle. seconds. Thanks to its transparent housing any bubbles that may be present in the dosing cylinder can be seen The space-saving Dosino and removed immediately and the valve position is al - The patented Dosino with its Dosing Unit can be mount-ways shown. Rinsing and preparation of the Dosing Unit ed directly onto the reagent bottle. This means that dos-can be carried out automatically; manual dismantling ing requires no additional bench space. Thanks to adapt-and rinsing are not necessary. Smart dosing elements with certification The Dosing Unit sets new standards with regard to reliabil-properly, i.e. type of reagent, titer, last titer determination, 07 ity. Intelligence «en miniature» in the form of an incon-shelf-life data and much more. In addition, the Titrando spicuous Data Chip makes this possible. This chip is present compares the data it has obtained with the selected in every 807 Dosing Unit. The Titrando automatically reads method and carries out a plausibility test. If the result is from it all the data that it needs to carry out the titration negative then a clear error message appears. 807 Dosing Unit 807 Dosing Unit Standard bottle thread GL45 Adapters for bottle threads (option) S40, 40 mm, 32 mm, 28 mm Buret cylinders available 2, 5, 10, 20, 50 mL Surface area needed for two dosing elements 150 mm x 240 mm Flat stopcock made of ceramic Glass for titrants Cylinder made of ETFE for auxiliary solutions and aggressive media 854 iConnect – green, digital and mobile 08 The iTrodes – simply intelligent The iTrodes of the new intelligent electrode generation confirm Metrohm’s long-standing leadership position in the field of potentiometric titration. The electrode used for the titration is the most important component of any titration system, and until now it has been just this electrode that has formed the last gap in traceability. The Titrando with 854 iConnect now closes this gap and therefore guarantees complete traceability of the analytical result to each component involved in the analysis. 854 iConnect – Measuring input «on a chip» Thanks to the most advanced electronics Metrohm has been able to reduce the measuring input to the size of a postage stamp. This means that the complete measuring input fits in the electrode cable head. It is automatically recognized and identified by its serial number. Digital data transfer Directly in the sensor, the analog/digital converter of the latest generation in the 854 iConnect converts the analog measuring signal into binary code. Digital data trans-mission means that the measuring signal is no longer susceptible to electrostatic influences. Interference-free trans mission can now always be guaranteed, no matter how long the electrode cable. Just take the measuring input with you! With the 854 iConnect the sensor and measuring input are always calibrated together and the calibration data is stored in the intelligent electrode. As the measuring in - put is no longer built into the instrument, the electrode and 854 iConnect can be used together with different titrators. The calibration procedure is no longer associ-ated with a particular titrator. Digital identification – no more mix-ups If the sensor is used with different instruments or if you 09 The built-in memory chip allows the storage of such wish to prevent inexperienced users from having to cali-important sensor data as article and serial numbers, calibrate the electrode on their own instruments then the bration data, calibration history, working life and calibra-electrode can be calibrated on a different instrument tion validity period. under defined conditions. The calibration data stored in the chip makes the electrode transferable; it does not All the sensor data is read in automatically when the need to be recalibrated each time that it is used with a iTrode is connected to the Titrando. Mix-ups or editing different instrument. errors are therefore eliminated. Compatible with all existing sensors The electrode is identified automatically. If the type of Despite its new digital measuring interface electrode is not the same as that defined in the method and intelligent sensors, the Titrando with then the user is informed. This means that it is not pos-combined analog and digital measuring sible to use an incorrect electrode. input also supports conventional sensors. This means that you can continue to use Storage of calibration data – outliers have no all your sensors. chance Monitoring functions allow the exclusion of electrodes whose calibration data lies outside the limits or whose calibration period has already expired. Uniquely intelligent – easy to operate 10 Favorites for quick method start Methods can be linked to a Favorite icon on the starting • The «Help» fixed key shows a context-related help text screen of the Touch Control. Start your titration by pressin the display. ing just one button. • The standard user methods can be modified to suit your requirements. Method templates and calculation Using our methods you can benefit from our many years formula templates are available for developing your of experience in titration. All titration methods developed own methods. Methods can be stored under meaning-on Metrohm Titrinos can be converted into Titrando ful method names (32 characters) and structured direc-methods automatically using a PC. tories can be used; this makes sorting, identification and searching much easier. As storage media for your methods, sample data and • Whereas in the expert dialog all settings are available, results you can use the Touch Control operation unit, a the routine dialog can be freely configured, i.e. it can USB memory stick or a PC with its numerous possibilities. be customized to meet the requirements of the par-This allows complete storage security to be achieved, ticular user. This means that users can load their «pro-with the prevention of method and data loss, plus an files» from the personal Keycard and see only those increase in operational security. operating elements that they actually need. Intelligence provides transparency The Titrando puts an end to puzzling out the meaning of Operating the Titrando System is simple and intuitive. coded error messages. It tells you exactly where the error The operator guidance system sets a new standard. In is in clear text. Not only this; it also suggests suitable addition, the following tools make life easier for the measures for remedying any faults. Titrando user: • The «Quick Access» function (direct parameters) allows direct access to the parameters required for the given application. These parameters may come from a wide range of different sections of the instrument program. This means that it is no longer necessary for you to click your way through different operating levels! «Quick Access» is invaluable for routine analysis. Routine Methods can be linked to a «Favorite» icon on the starting screen of the Touch Control. Titrations are started by pressing just one button. 11 The Titrando in the modern laboratory Data management is knowledge management Network integration Data must always be available: either for direct informa-If you want to connect your Titrando System directly to a tion, for transfer to a data system, for further processing superior data system, there is nothing in the way: The or for an audit. The data that your Titrando System pro-Touch Control opens up internal networks (Intranet, vides you with can be printed out and stored in a con-LIMS1, LAN2) to the Titrando, with all that this implies. ventional manner. However, all advanced data manage-Network printers can be used for printing out analysis ment functions are available, for example storage on a reports. Print reports on a network printer or save them USB memory stick that is simply inserted in the Touch on a network storage. Send your results directly to your Con trol. LIMS or store them in the Touch Control’s archive. When you work with tiamo TM, you can use all the storage Never has integration into your LIMS structure options offered by the PC world, for example hard drives, been so easy! network drives, servers, Intranet… On request the Titrando can produce a machine-readable PC/LIMS report. There is no question: As for data storage and transfer, the Titrando is a state-of-the-art instrument. 1LIMS = Laboratory Information Management System 2LAN = Local Area Network 12 Compatibility and traceability GLP, GMP, 21 CFR Part 11 are becoming increasingly im - The Titrando allows strict control of rights of access using portant in day-to-day laboratory life. The Titrando System login and password. The requirements defined in FDA is entirely oriented towards quality management in the Regulation 21 CFR Part 11 regarding «electronic signa-laboratory and offers the following possibilities: ture» and «electronic record» are fulfilled in the stand-alone system using the Touch Control operating unit as • Each time that it is switched on the Titrando System well as in the version controlled via PC. This also applies carries out a self-diagnosis. to the other points contained in this regulation, namely • If it has been programmed accordingly then the instru-the protection of electronic records against accidental or ment will remind you about any validation or service intentional alteration and complete traceability. The work that is due. Titrando with Touch Control is the only stand-alone titra- • You can enter limits for results; their observance will be tion system with Audit Trail. checked for each determination. • The titer of the titrant can be monitored as a function Quality management at Metrohm of time in both tabular form or as a graph, similar to a Quality has always been extremely important for control card. Metrohm. On 5 November 1993 our company achieved • The «calibration history» of the sensors can be called the ISO 9001 certificate of quality. The Metrohm quality up. This means, for example, that alterations to the management system is continually being perfected and sensor caused by aging can be recognized before they checked by both internal and external audits. affect the results. • All changes to the data are documented; traceability is guaranteed. Integrated automation Automation pays dividends! It’s so simple 13 Increasing sample numbers, time-consuming sample pre-You connect the sample changer to the Titrando’s USB paration steps and unattended overnight operation are port and the world of automation opens up to you. good reasons for using sample changers. The Titrando has the necessary intelligence to control sample changers and offers – together with the 814 USB Sample Processor and 815 Robotic USB Sample Processor XL – a high de gree of automation at low investment costs. tiamo TM – titration and more! 14 tiamo TM is a control and database software for titrators, Overcomes limits dosing devices and sample changers that allows com-The tiamo TM database provides all the important tools plete laboratory automation. This is why the name for the management, searching and grouping of results. tiamo TM stands for «titration and more» – tiamo TM can Quick filters allow the user to search through thousands do much more than just titrate. of results in a matter of seconds and show the searched-for information in a clear way. Chart plots provide a rapid Easy to use overview of the chronological sequence of results. The The modern user interface makes it easy for users to user can utilize all the possibilities for re-calculation and familiarize themselves quickly with tiamo TM. All com-re-evaluation. mands and controls are to be found exactly where you expect them to be. The layout manager can be used to LIMS & Co. configure the screen view individually for each user. This The acceptance of PC-controlled analytical systems de - means that the users see only those windows or buttons pends largely on the possibility of simple and affordable that are required for their work. This shortens the famil-integration in existing laboratory information systems, iarization period for routine users to a minimum. central databases and long-term archiving systems. Data generated in tiamo TM is exported in CSV or XML format. Parallel titration This makes possible the simple connection to all the Both measuring inputs and all the Dosinos connected to usual LIMS products found on the market. Analysis a Titrando can be controlled independently of each other. re ports can be generated simply and flexibly with the In combination with tiamo TM this allows the parallel titra-new report generator, which allows the free definition of tion of two identical or two different samples with one report templates. In this way one or more determinations single titrator. can be shown at any time with a freely selectable layout in pdf format or as a paper printout. The layout of the screen view can be confi gured as desired and required tiamo TM increases efficiency All requirements met 15 The graphical method editor gets more out of your titra- tiamo TM also sets new standards with respect to comply-tion system. Methods can be drawn up easily and quickly ing with GMP, GLP and FDA requirements. tiamo TM has by using the numerous templates. You can program and been consistently oriented to comply with FDA Regulation link actions that are to be carried out at the same time. 21 CFR Part 11 and its customer-specific interpretations. tiamo TM is flexible and adapts itself to your analytical sequences – not vice versa. Live curve and progress of the titration can be followed in real time Technical specifications 16 901 Titrando Dosing elements Space for two 800 Dosinos with 807 Dosing Unit Attachment of additional dosing Up to 12 x 805 Dosimat with 806 Exchange Unit elements Up to 12 x 800 Dosino with 807 Dosing Unit Intelligent Exchange Unit/Dosing yes Unit with integral Data Chip Dosing steps per cylinder volume with 800 Dosino: 10,000 (resolution) Operation, dialog Touch Control / tiamo TM (from 2.0) Stirrers, titration stand 4 x 801 Magnetic Stirrer or 4 x 802 Rod Stirrer with 804 Titration Stand or 803 KF Titration Stand Attachment of Dosimats, Dosinos 4 MSB connectors stirrers (Metrohm Serial Bus, Daisy Chain) Sample Changer attachment 1 sample changer via USB Attachment of balances, printer, PC, PC keyboard, barcode reader Via 2 USB Slave Ports, RS-232/USB Box (option) and/or Lab Link Attachment of additional measuring modules (867 pH Module or yes 856 Conductivity Module) Attachment of a USB memory stick for methods, results, identification yes (Touch Control) card, ... Temperature sensor Pt 1000 or NTC Real-time curve display on Touch Control (90 mm x 120 mm yes color graphics LCD) or PC screen DET Dynamic Equivalence-point no Titration MET Monotonic Equivalence- no point Titration SET Titration to a preset end point with automatic yes conditioning KF Volumetric Karl Fischer titration with automatic yes conditioning STAT Titration to a preset control point and maintaining the no corresponding measured value MEAS Measuring mode for pH, Resolution: 0.001 pH, 0.1 mV, 0.1 °C; U/mV, T/°C Measuring interval: 100 ms MEAS CONC Direct measurement using ISE and calculation no of concentration CAL Calibration with automatic yes buffer recognition 901 Titrando 17 I & U – integrated pol pol programmable Polarizer yes Sequences can be freely programmed by the user yes Method and sample data memory, memory, result memory, data base yes Dialog languages: English and German; additional languages yes can easily be added Comprehensive GLP/GMP functions; meets requirements of yes FDA 21 CFR Part 11 Intelligent dosing devices yes Intelligent electrodes «iTrodes» yes GLP-compliant electrode test yes Check for result limits yes Access control by means of login with password protection; yes Electronic Signature Liquid handling with expanded dosing instructions for the yes 800 Dosino 18 Ordering information 901 Titrando 2.901.0010 901 Titrando with double Pt-wire electrode, titration vessel and additional accessories for Karl Fischer titration 19 Options 2.900.0010 Touch Control for Titrando 6.6056.231 tiamo TM 2.3 light 6.6056.232 tiamo TM 2.3 full 6.6056.233 tiamo TM 2.3 multi 2.800.0010 800 Dosino 2.801.0040 801 Magnetic Stirrer 2.802.0010 802 Rod Stirrer 2.803.0010 803 KF Titration Stand 2.804.0040 804 Ti Stand 2.854.0010 854 iConnect for connection of intelligent electrodes «iTrodes» 6.2148.010 Remote Box MSB 6.2148.020 RS-232/USB Box Intelligent 807 Dosing Units equipped with Data Chip; with glass cylinder for 800 Dosino, including accessories and two buret tips, one of them with micro outlet valve 6.3032.120 Buret volume 2 mL 6.3032.150 Buret volume 5 mL 6.3032.210 Buret volume 10 mL 6.3032.220 Buret volume 20 mL 6.3032.250 Buret volume 50 mL www.metrohm.com G, CH-9101 Herisau ohm A witzerland by Metr , printed in S SW -04 fi cations − 2011 Subject to modi Layout by Ecknauer+Schoch A 8.901.5002EN