888/890 Titrando Enter the Titrando world 888 Titrando – potentiometric titrator 890 Titrando – Karl Fischer titrator 02 The advantages at a glance • Touch Control with large color screen 03 • Titrations software tiamo TM for operation via PC • Intuitive operation • Intelligent Exchange Units • Intelligent electrodes «iTrodes» for the 888 Titrando • Potentiometric titration with the 888 Titrando • Karl Fischer titration with the 890 Titrando • Sample Processor control • Network integration via 900 Touch Control • Online help • Complies with FDA regulation 21 CFR Part 11 (with 900 Touch Control or tiamo TM full) • USB interfaces for sample changer, printer, PC keyboard, barcode reader ... Overview of the 888 Titrando and 890 Titrando 04 888 Titrando 890 KF Titrando Intelligent dosing elements for titration 1 integrated Dosimat 1 integrated Dosimat One additional titration buret for Exchange Unit (800 Dosino / 805 Dosimat) when used with tiamo TM Additional dosing elements (dispensing only) 3 x 805 Dosimat 3 x 805 Dosimat with Exchange Unit with Exchange Unit 3 x 800 Dosino 3 x 800 Dosino with Dosing Unit with Dosing Unit Intelligent Exchange Unit with integral datachip Yes Increments per cylinder volume (Exchange Unit) 20’000 Measuring interface for pH, U/mV, T/°C 1 – Intelligent electrodes «iTrodes» 1 – Measuring input for polarizable electrodes 1 Operation, dialog Touch Control or tiamo TM Stirrers, titration stand 801 Stirrer (magnetic) or 802 Stirrer (rod) with 804 Ti Stand or 803 Ti Stand (KF) Connections for stirrers and intelligent dosing elements 4 MSB connections (Metrohm Serial Bus, Daisy Chain) Connection for sample changer 1 sample changer via USB Connections for balances, printer, PC, Via 2 USB Slave Ports, RS-232/USB-Box PC keyboard, barcode reader and/or Lab Link (option) Temperature sensor Pt 1000 or NTC – Differential amplifier Option – Real-time curve display on Touch Control or PC screen Yes DET Dynamic equivalence-point titration Yes – MET Monotonic equivalence-point titration Yes – SET Titration to preset endpoints with automatic Yes – conditioning KFT Volumetric Karl Fischer titration with automatic Yes (with tiamo TM) Yes conditioning MEAS Measuring mode for pH, U/mV, T/°C, I , U Yes – pol pol CAL Calibration with automatic buffer recognition Yes – Additional titration curve evaluation for: fixed endpoints, Yes – pK values (HNP) Comprehensive GLP/GMP functions; complies with Yes FDA 21 CFR Part 11 Uniquely intelligent – easy to operate Call up the method – press start 05 Standard user methods facilitate familiarization with the system and allow the Titrando to be usedimmediately. By using our methods you can profit from our many years of experience in the titration field. As storage media for your methods, sample data and resultsthere are the Titrando itself, a USB memory stick or the PC with its nu - merous possibilitie Intelligence creates transparency Operating the Titrando System is simple and intuitive. In addition, the following tools make lifeeasier for the Titrando user: • The «Quick Access» function (direct parameters) al - lows direct access to the parameters requiredfor the given application. This means that it is no longer ne - cessary for you to click your waythrough different ope rating levels! • The «Help» fixed key shows a content-related help text in the display. The «Follow me» helpfunction is available when working with a PC. Continuous expla-nations about the current surroundings are given in a separate window and further possible procedures are indicated. • The standard user methods can be modified to suit your requirements. Method templates andcalculation formula templates are available for developing your own methods. Methods can bestored under mean-ingful method names (32 characters) and structured directories can be used; this makes sorting, identification and searching much easier. • Whereas in the expert dialog all settings are available, the routine dialog can be freely configured, i.e. it can be custom-made to meet the requirements of the particular user. Smart dosing elements with certification 06 Metrohm’s Exchange Unit sets new standards with re - In addition, each Exchange Unit is provided with serial gard to reliability. Each Exchange Unit isequipped with a and cylinder numbers and is supplied with a certificate of data chip. The Titrando automatically reads from it all the its own. The Titrando checks the preset intervals for the data that it needs tocarry out the titration properly, i.e. titer determination of thetitrant. This ensures that work type of reagent, titer, last titer determination, shelf-life is always carried out with the exact titer. data andmuch more. In addition, the Titrando compares the data it has obtained with the selected methodand carries out a plausibility test. If the result is negative then a clear error message appears. The iTrodes – electrodes with brains The electrode used for the titration is really the most 07 important component of any titration system.The iTrodes represent our new intelligent electrode generation and guarantee complete traceabilityof the analytical result to each component participating in the analysis. Digital identification – no more mix-ups The built-in memory chip allows the storage of such im - portant sensor data as article and serialnumbers, calibration data, calibration history, working life and calibration validity period. All thesensor data is read in automa tically when the iTrode is connected to the 888 Titrando. Mix-ups or editing errors are therefore eliminated. The electrode is identified automatically. If the type ofelectrode is not the same as that defined in the method then the user is informed. This means that it is not possible to use an incorrect electrode. Storage of calibration data – outliers have no chance Monitoring functions allow the exclusion of electrodes whose calibration data lies outside thelimits or whose ca lib ration period has already expired. If the sensor is used with different instruments or if you wish to prevent inexperienced users from having to calibrate the electrode on theirown instruments then the electrode can be calibrated on a different instrument under definedcondi-tions. The calibration data stored in the chip makes the electrode transferable; it does notneed to be recalibrated each time that it is used with a different instrument. Compatible with all existing sensors Despite its new digital measuring interface and intelligent sensors, the 888 Titrando with combined analog and di - gi tal measuring input also supports conventional sensors. This means that you can continue to use all your sensors. 08 Karl Fischer titration with the 890 Titrando The sophisticated control algorithm and the increased volume resolution of the 890 Titrando’s intelligent Ex - change Unit guarantee highly precise resultscombined with easy and intuitive user guidance. The KF icons show you at a glance whether the instrument is still busy conditioning or whether you can start the water determination. T he iodine drop indicates the KF reagent addition during conditioning. Conditioning is finished and the sample can be added. The electrode test and the newly created parameter The 803 Ti Stand for KF titration «safety stop» prevent cellrun-over during conditioning. If, Use the 803 Ti Stand for stirring and manually exchang-for example, the electrode is not connectedcorrectly or ing the spent titration vessel contents. With the integra-the titration cell is very humid, conditioning is stopped ted membrane pump, solvent can be aspirated or added after a giventime or a given volume of KF reagent added. without the cell havingto be opened. This translates into This new feature increases work safety in your labora tory. vastly reduced conditioning times. The Titrando in the modern laboratory Touch Control = user comfort Compatibility and traceability 09 The Touch Control is a decidedly ergonomic and modern The Titrando System is entirely oriented towards quality operating element. Due to its USB and ethernet interface management in the laboratory and offers thefollowing you can store any data either on a USB memory stick, in pos sibilities: your network (as PDF file or for exporting it to your LIMS), or you can print out this data on any printer in • Auto-diagnostic test after switching on. your network or conncected via USB. • Monitoring of validation and service intervals. • Monitoring of the calibration data of sensors. Titrando and PC – a harmonic duo • Monitoring of titers and results. The Titrations software tiamo TM – titration and more – • All changes to the methods are documented. opens up many other possibilities such as database func- • Strict control of rights of access using login and tionality, parallel titration with several instruments and password, complying with FDA Regulation 21 CFR much more. Part 11 regarding «electronic signature» and «electronic record». If you work with tiamo TM, you can use all the storage op tions offered by the PC world, and on request the Titrando can produce a machine-readable PC/LIMS re - port. Integrated automation 10 Increasing sample numbers, time-consuming sample pre-and calibration of the electrodes – the 814 USB Sample paration steps and unattended overnightoperation are Processor and 815 Robotic USB Sample ProcessorXL offer good reasons for using sample changers. The 888 and a high degree of automation at low investment costs. It’s 890 Titrandos have the necessary intelligence to control amazing: You simply connect the sample changer to the sample changers. Whether you require small or large Titrando’s USB port and the world of automation opens sample capacity, one or two working stations, sample up to you. Our sample changer brochure supplies de-me tering, sample preparation, liquid handling, rinsing tail ed information on the automation possibilities. Ordering information, options 2.888.0110 888 Titrando with Touch Control 11 1 × 2.888.0010 888 Titrando 1 × 2.900.0010 900 Touch Control 1 × 2.801.0040 801 Stirrer (magnetic) 1 × 6.3026.220 Intelligent Exchange Unit (20 mL) 1 × 6.0262.100 Ecotrode plus 1 × 6.2104.020 Electrode cable 2.888.0210 888 Titrando with tiamo TM light 1 × 2.888.0010 888 Titrando 1 × 6.6056.251 tiamo TM 2.5 light 1 × 6.2151.000 Cable USB A – Mini DIN 8 pins 1 × 2.801.0040 801 Stirrer (magnetic) 1 × 6.3026.220 Intelligent Exchange Unit (20 mL) 1 × 6.0262.100 Ecotrode plus 1 × 6.2104.020 Electrode cable 2.890.0110 890 Titrando with Touch Control 1 × 2.890.0010 890 Titrando 1 × 2.900.0010 900 Touch Control 1 × 2.803.0010 803 Ti Stand 1 × 6.3026.210 Intelligent Exchange Unit (10 mL) 2.890.0210 890 Titrando with tiamo TM light 1 × 2.890.0010 890 Titrando 1 × 6.6056.251 tiamo TM 2.5 light 1 × 6.2151.000 Cable USB A – Mini DIN 8 pins 1 × 2.803.0010 803 Ti Stand 1 × 6.3026.210 Intelligent Exchange (10 mL) Optional accessories 2.805.0010 805 Dosimat 6.3026.120 Intelligent Exchange Unit 1 mL for 805 Dosimat 6.3026.150 Intelligent Exchange Unit 5 mL for 805 Dosimat 6.3026.210 Intelligent Exchange Unit 10 mL for 805 Dosimat 6.3026.220 Intelligent Exchange Unit 20 mL for 805 Dosimat 6.3026.250 Intelligent Exchange Unit 50 mL for 805 Dosimat 2.800.0010 800 Dosino 6.3032.120 Intelligent Dosing Unit 2 mL for 800 Dosino 6.3032.150 Intelligent Dosing Unit 5 mL for 800 Dosino 6.3032.210 Intelligent Dosing Unit 10 mL for 800 Dosino 6.3032.220 Intelligent Dosing Unit 20 mL for 800 Dosino 6.3032.250 Intelligent Dosing Unit 50 mL for 800 Dosino 2.804.0040 804 Ti Stand with support 2.802.0040 802 Stirrer (rod) for 804 6.2148.050 USB/RS-232 converter for 900 Touch Control 6.2151.030 Cable USB A – USB B / 0.6 m 2.141.0100 Thermal printer Custom Neos-N USB www.metrohm.com 8 Subject to change Layout by Ecknauer+Schoch ASW, printed in Switzerland by Metrohm AG, CH-9100 Herisau 8.888.5003EN – 2017-0