902 Titrando Intelligent potentiometric titrator STAT titrator and synthesis controller STAT titrator and synthesis controller 02 Highlights • One touch titration – favorites for method shortcuts • iConnect – mobile measuring input with digital data transmission • iTrodes – intelligent sensors for automatic electrode recognition • GLP-compliant electrode test • Intelligent dosing elements • Potentiometric STAT titration • Sample Processor control • Client-server database with tiamo • Parallel titration with tiamo • Direct network access with 900 Touch Control • Liquid handling with the patented Dosino • Complies with GMP/GLP and FDA Regulations such as 21 CFR Part 11 • USB interfaces for sample changer, printer, PC keyboard, barcode reader ... Dosing à la carte 04 The space-saving Dosino Basically, titration is all about dosing intelligently. With the Titrando system, the patented Dosino with its Dosing Unit can be mounted directly on the reagent bottle. This means that dosing requires no additional bench space. Thanks to adapters, any reagent bottle can be used directly. The Dosino houses state-of-the-art electronics and micromechanics. The Dosing Unit can be exchanged within seconds. Thanks to its transparent housing, any bubbles that may be present in the dosing cylinder can be seen and eliminated immediately, and the valve posi-tion is always shown. Rinsing and preparation of the Dosing Unit can be carried out automatically; manual dismantling and rinsing are not necessary. Smart dosing elements with certification The Dosing Units set new standards with regard to reli-In addition, the Titrando compares the data it has ob - 05 ability. Intelligence «en miniature» in the form of a Data tained with the selected method and carries out a plau-Chip makes this possible. This chip is present in every 807 sibility test. If the result is negative, a clear error message Dosing Unit. The Titrando automatically reads from it all appears. the data that it needs to carry out the titration properly, i.e. type of reagent, titer, last titer determination, shelf life data and much more. Details 807 Dosing Unit Standard bottle thread GL45 Adapters for bottle threads (option) S40, 40 mm, 32 mm, 28 mm Buret cylinders available 2, 5, 10, 20, 50 mL Surface area needed for two dosing elements 150 mm x 240 mm Flat stopcock made of Ceramic Glass for titrants Cylinder made of ETFE for auxiliary solutions and aggressive media iTrodes with 854 iConnect – the smartest sensors around 06 Metrohm iTrodes – electrodes with a brain The electrode used for the titration is the most important component of any titration system. Until now the electrode was the last gap in traceability. The Titrando with 854 iConnect now closes this gap and therefore guarantees complete traceability of the analytical result to each component of the analytical system. 854 iConnect – Measuring input «on a chip» Thanks to the most advanced electronics Metrohm has been able to reduce the measuring input to the size of a postage stamp. This means that the complete measuring input fits in the electrode cable head (the 854 iConnect). It is automatically recognized and identified by its serial number. Digital data transfer Directly at the sensor, the the analog measuring signal is converted into binary code by the the 854 iConnect. Due to the digital transmission of the data the measuring signal is no longer susceptible to electrostatic influences. Interference-free transmission can now always be guaranteed, no matter how long the electrode cable is. Just take the measuring input with you! With the 854 iConnect the sensor and measuring input are always calibrated together; the calibration data is stored in the intelligent electrode. As the measuring in - put is no longer built into the instrument, the electrode and 854 iConnect can be used with different titrators. The calibration procedure is no longer restricted to a particular titrator. Digital identification – no more mix-ups 07 The built-in memory chip allows the storage of such im - If the sensor is used with different instruments or if you portant sensor data as article and serial numbers, calibra-wish to prevent inexperienced users from having to cali-tion data, calibration history, working life and calibration brate the electrode on their own instruments then the validity period. electrode can be calibrated on a different instrument under defined conditions. The calibration data stored in All sensor data is read in automatically when the iTrode the chip makes the electrode transferable; it does not is connected to the Titrando. Mix-ups or editing errors need to be recalibrated each time that it is used with a are therefore eliminated. different instrument. The electrode is identified automatically. If the type of Compatible with all existing sensors electrode is not the same as that defined in the method Despite its new digital measuring interface then the user is informed. Thus, it is not possible to use and intelligent sensors, the Titrando with a wrong electrode. combined analog and digital measuring input also supports conventional sensors. Storage of calibration data – no chance for outliers Monitoring functions allow the exclusion of electrodes whose calibration data lies outside the limits or whose calibration period has expired. The Titrando System at a glance 08 Due to its modular design the Titrando System can be adapted to any application. It meets the requirements of FDA Regulation 21 CFR Part 11. Benefit from the system’s intelligence and communication capabilities! The Titrando accelerates method development and simplifies routine operation. The Data Chip of the Exchange Unit and Dosing Unit contains all important titrant data. The intelligent sensor «iTrode» prevents the use of a wrong or expired electrode. The large color screen of the 900 Touch Control operating unit keeps you informed about the instrument condition and offers uniquely comfortable operator guidance. iConnect and iTrodes – digital data transfer and automatic electrode recognition. The Data Chip of the intelligent sensor contains all important sensor data. NEW: The automatic GLP-compliant electrode test allows 09 an objective evaluation of the electrode and leaves nothing to chance. Reliable and reproducible results are guaranteed. Numerous ready-to-use methods and titration examples make familiarization with the system easy. Method templates and calculation formula templates are available for developing your own methods. Optimal reagent handling by either Exchange Unit or Dosing Unit. More intelligence: The Data Chip of the Exchange Unit or Dosing Unit contains all important titrant data. The 900 Touch Control provides access to your Intranet. Print your re ports on a network printer,or save your data on a USB stick. When combining the tiamo software and the Titrando, you benefit from a Client-Server database. Parallel titration – using the tiamo software, your Titrando can work with two titration cells in parallel. Your Titrando System can be fully automated, including sample preparation (weighing, homogenization, filtra-tion, pipetting). Superior intelligence – easy to operate 10 Favorites for quick method start Methods can be linked to a «Favorite» icon on the start- • The «Help» fixed key shows a context-related help text ing screen of the 900 Touch Control operating unit. You in the display. can start titrating by pressing just a single button! • The «Follow me» help function is available when working with a PC. Continuous explanations about the Using our methods you benefit from Metrohm’s many current surroundings are given in a separate window years of experience in titration. All titration methods and further possible procedures are indicated. de veloped on Metrohm Titrinos can be automatically • The standard user methods can be modified to suit converted into Titrando methods using a PC. your particular requirements. Method templates and calculation formula templates are available for develop-Store your methods, sample data and results using either ing your own methods. Methods can be stored under the Touch Control operating unit, a USB stick or a PC. meaningful names (32 characters) and structured This provides for complete storage security, prevents directories can be used; this makes sorting, iden tifi-method or data loss, and also increases operational cation and searching much easier. security. • Whereas in the expert dialog all settings are available, the routine dialog can be freely configured to meet the Intelligence for more transparency requirements of the particular user. Thus, users can Operating your Titrando System is simple and intuitive. load their «profiles» from a personal keycard and see The following features further simplify using your only those operating elements that they actually need. Titrando: The Titrando puts an end to puzzling out the meaning of • The «Quick Access» function (direct parameters) gives coded error messages. It tells you exactly where the error you direct access to the parameters required for the is using plaintext. Moreover; it suggests suitable meas-given application. You do not have to click your way ures for troubleshooting. through different operating levels any more. «Quick Access» is invaluable for routine analysis. Start your titration at the push of a button: Routine methods can be linked to a «Favorite» icon on the starting screen of the 900 Touch Control. 11 The Titrando in the modern laboratory Data management is knowledge management Never has integration into your LIMS structure Data must always be available: for direct information, for been so easy! transfer to a data system, for further processing or for an audit. The data that your Titrando System provides you PDF reports at the touch of a button with can be printed out and stored in a conventional Using the PDF generator, you can edit, store, and print manner. However, the complete range of mo dern data forge-proof analysis reports as PDF files at the push of management is also available, for example storage on a button. USB stick that is simply inserted in the 900 Touch Control. 14 favorites per user for fast method access When you work with tiamo, you can use all the storage Up to 14 favorite icons per user can each be linked to a options offered by the PC world, for example hard drives, method on the start screen of the 900 Touch Control. network drives, servers, Intranet ... If required, your Titrando Thus, you have instant access to your most frequently generates a machine-readable PC/LIMS report. used methods and start them at a single touch of an icon. Ethernet connection If you want to connect your Titrando system directly to a higher data system, there is nothing in the way: the 900 Touch Control opens up internal networks (Intranet, LIMS1, LAN2) to the Titrando. Network printers can be used for printing reports. 1 LIMS = Laboratory Information Management System 2 LAN = Local Area Network 12 Compatibility and traceability GLP, GMP, and 21 CFR Part 11 are becoming increasingly Your Titrando enables strict control of rights of access important in the modern laboratory. The Titrando System using login and password. The requirements defined in is entirely oriented towards quality management in the FDA Regulation 21 CFR Part 11 regarding «electronic sig-laboratory and offers the following possibilities: nature» and «electronic record» are fulfilled both in the stand-alone system using the Touch Control operating • Each time that it is switched on the Titrando System unit and in the version controlled via PC. This also applies carries out a self-diagnosis. to the other points stipulated in this regulation, i.e. the • If programmed accordingly, the instrument will remind protection of electronic records against accidental or you about any validation or service work that is due. intentional alteration and the complete traceability of • You can enter limits for results; their observance will be results. The Titrando with Touch Control is the only checked for each determination. stand-alone titration system with audit trail. • The titer of the titrant can be monitored as a function of time in both tabular form or as a graph, similar to a Quality management at Metrohm control card. Quality has always been extremely important for • The calibration history of the sensors can be called up. Metrohm. On November 5, 1993 our company was re - This means, for example, that alterations to the sensor warded the ISO 9001 certificate of quality. The Metrohm caused by aging can be recognized before they affect quality management system is continually being perfect-results. ed and checked by both internal and external audits. • All changes to the data are documented; traceability is guaranteed. Integrated Automation Perfectly modular design 13 The possibilities for upgrading the Titrando System are amazing. First the bare figures: The basic unit consists of a Titrando with one measuring in ter face. This basic unit can be upgraded to form a super-titrator that controls 12 burets and boasts 6 galvanically separated measuring interfaces. Between these two extremes lies the whole spectrum of Titrando possibilities. Among them you will certainly find a Titrando System that meets the de mands of your particular application. Your Titrando System meets ever new and more complex challenges as it can be up - graded at any time. Automation pays dividends Increasing sample numbers, time-consuming sample preparation steps and unattended overnight operation are good reasons for using sample changers. The Titrando has the necessary intelligence to control sample changers and offers – in combination with the 814 USB Sample Processor and 815 Robotic USB Sample Processor XL – a high degree of automation at moderate costs. 14 STAT titration The determination of enzyme activity (lipase, trypsin, Tandem dosing etc.) or of the release kinetics of antacid tablets requires Tandem dosing is a feature that prevents dosing interrup-a titrator that rapidly adjusts to a preset pH value and tions when the buret is refilled during the titration – a keeps it constant for a long period. The controller of the second buret immediately takes over. Thus, rapid reac-Titrando has been optimized for this task and is one of tions with a high reagent consumption can be moni tored the best on the market. It can also be used to determine with maximum accuracy. Tandem dosing is also available the kinetics of acid-base or redox reactions. for simple and monitored dosing. The Titrando in the synthesis laboratory In the synthesis laboratory different challenges are faced 15 to those encountered in titration. Here a particular pH value must be kept constant or multiple dosing has to be carried out under exactly defined conditions. This means that a certain volume of a solution must be added within a fixed time. In addition to controlled dosing, the parameters pH (or potential) and temperature are continuously recorded, thus providing complete documentation of the synthesis procedure. Everything under control If a monitored parameter should infringe the set limits, the user can decide whether dosing should be continued or interrupted and then continued manually or automa - ti cally, again observing the limits. Controller As an innovation your Titrando can perform control tasks. External devices can be controlled by means of freely programmable TTL signals or communication via RS 232. Thus, you can operate external heating and cooling de - vices, pumps or similar equipment by remote control. Example of a neutralization process: 1. DOS Addition of 150 mL reagent in 10 min with temperature monitoring 2. Pause 5 min under stirring 3. STAT Adjust pH = 7.5 with temperature monitoring 4. SET Post reaction, for example, during 10 min; endpoint pH = 7.5 tiamo – titration and more! 16 tiamo is a control and database software for titrators, Straightforward data management dosing devices and sample changers that allows com- The tiamo database provides all the important tools for plete laboratory automation. This is why the name the management, searching and grouping of results. tiamo stands for «titration and more» – tiamo can do Quick filters allow you to search through thousands of much more than just titrate. results in a matter of seconds and show the searched-for information in a clear way. Chart plots provide a rapid Easy to use overview of the chronological sequence of results. You The modern user interface makes it easy for users to fa - can use a multitude of possibilities for re-calculation and mi liarize themselves with tiamo. All commands and re-evaluation. controls are to be found exactly where you expect them. The layout manager can be used to configure the screen LIMS & Co. view individually for each user. Users see only those win-The acceptance of PC-controlled analytical systems de - dows or buttons that are required for their work. This pends largely on their simple and affordable integration shortens the familiarization period for routine users to a into existing laboratory information systems, central minimum. databases and long-term archiving systems. Data generated in tiamo is exported in CSV or XML format. This Parallel titration en ables the simple connection to virtually all LIMS prod-Both measuring inputs and all the Dosinos connected to ucts currently available on the market. Analysis reports a Titrando can be controlled independently of each other. can be generated with the new report generator, which In combination with tiamo this allows the parallel titra-allows the free definition of report templates. One or tion of two identical or two different samples with a more determinations can be shown at any time with a single titrator. freely selectable layout in pdf format or, if you prefer, as a paper printout. Convenient: the tiamo interface is freely configurable. Any user can arrange the screen windows as he wishes. tiamo increases efficiency All requirements met 17 The graphical method editor gets more out of your titra- tiamo also sets new standards with respect to com-tion system. Methods can be drawn up easily and pliance with GMP, GLP and FDA requirements. tiamo quickly by using the numerous templates. You can pro-has been consistently oriented to meet FDA Regulation gram and link actions that are to be carried simultane-21 CFR Part 11 and its customer-specific interpretations. ously. tiamo is flexible and adapts itself to your analytical sequences – not vice versa. A clear view: only the parameters that are needed appear in the window, so the layout is always clear and tidy. Technical specifications 18 902 Titrando Dosing elements Space for two 800 Dosinos with 807 Dosing Unit Up to 9 x 805 Dosimat with 806 Exchange Unit Attachment of additional dosing elements Up to 12 x 800 Dosino with 807 Dosing Unit Intelligent Exchange Unit/Dosing Unit with integral yes Data Chip Dosing steps per cylinder volume (resolution) 902 Titrando with 800 Dosino: 10‘000 Operation, dialog Touch Control or PC Control / tiamo 4 x 801 Magnetic Stirrer or 4 x 802 Rod Stirrer Stirrers, titration stand with 804 Titration Stand Attachment of Dosimats, Dosinos, stirrers 4 MSB connectors (Metrohm Serial Bus, Daisy Chain) Sample Changer attachment 1 sample changer via USB Attachment of balances, printer, PC, PC keyboard, Via 2 USB Slave Ports, USB RS Converter (optional) barcode reader and/or Lab Link Attachment of additional measuring modules yes (867 pH Module or 856 Conductivity Module) USB stick for methods, results, Keycard yes (Touch Control) (user identification), backup Temperature sensor Pt 1000 or NTC Differential amplifier Option Real-time curve display on Touch Control yes (90 mm x 120 mm, high-res color screen or PC screen SET Titration to a preset endpoint with automatic yes conditioning STAT Titration to a preset endpoint and maintaining yes the corresponding measured value Resolution: 0.001 pH, 0.1 mV, 0.1 °C; MEAS Measuring mode for pH, U/mV, T/°C Measuring interval: 100 ms CAL Calibration with automatic buffer recognition yes Second, galvanically separated measuring interface for Option pH, U/mV, T/°C I and U – integrated programmable Polarizer yes pol pol Sequences can be freely programmed by the user yes Method and sample data memory, result memory, yes data base Dialog languages: English, German, Chinese; additional yes languages can easily be added Comprehensive GLP/GMP functions; meets requirements yes of FDA 21 CFR Part 11 Intelligent electrodes «iTrodes» yes GLP-compliant electrode test yes Check for result limits yes Access control by means of login with password yes protection; Electronic Signature Liquid handling with expanded dosing instructions for yes the 800 Dosino Ordering information 902 Titrando 19 2.902.0010 902 Titrando with one combined analog/digital measuring input Options 2.900.0010 900 Touch Control 6.6056.252 tiamo Full 2.800.0010 800 Dosino 2.801.0040 801 Magnetic Stirrer 2.802.0040 802 Rod Stirrer for 804 2.804.0040 804 Ti Stand for 802 Rod Stirrer 2.805.0010 805 Dosimat 2.854.0010 854 iConnect for connection of intelligent electrodes «iTrodes» 2.141.0100 USB thermal printer Neo’s (for 900 Touch Control) 6.2148.010 Remote Box MSB 6.2148.050 USB/RS-232 Converter 6.2061.010 Reagent Organizer, holds two 1 L bottles; for dosing with Dosinos and Dosing Units Intelligent 807 Dosing Units equipped with Data Chip; with glass cylinder for 800 Dosino, including accessories and two buret tips, one of them with micro outlet valve 6.3032.120 Buret volume 2 mL 6.3032.150 Buret volume 5 mL 6.3032.210 Buret volume 10 mL 6.3032.220 Buret volume 20 mL 6.3032.250 Buret volume 50 mL Intelligent 806 Exchange Units equipped with Data Chip for 805 Dosimat; with glass cylinder and flat PCTFE/PTFE stopcock 6.3026.110 1 mL Exchange Unit with one tip each for titration and dosing 6.3026.150 5 mL Exchange Unit with one tip each for titration and dosing 6.3026.210 10 mL Exchange Unit with one tip each for titration and dosing 6.3026.220 20 mL Exchange Unit with one tip each for titration and dosing 6.3026.250 50 mL Exchange Unit with one tip each for titration and dosing www.metrohm.com G, CH-9100 Herisau ohm A witzerland by Metr , printed in S SW 10 Subject to change Layout by Ecknauer+Schoch A 8.902.5002EN – 2016-