904/905 and 906/907 Titrando Intelligent potentiometric titrators Karl Fischer titrators STAT titrators The intelligent all-rounders for the modern titration laboratory 02 03 Highlights • Touch and titrate – Favorite icons for quick titration start • Generates PDF files without a PC • iConnect – mobile measuring input with digital data transmission • iTrodes – intelligent sensors for automatic electrode recognition • GLP-compliant electrode test • Intelligent dosing elements • Potentiometric, Karl Fischer and STAT titration • Sample Processor control • Client-server database with tiamo TM • Parallel titration with tiamo TM • Direct access to intranet and internet • Liquid handling with the unique Dosino • Complies with GMP/GLP and FDA Regulations such as 21 CFR Part 11 • USB interfaces for sample changer, printer, PC keyboard, barcode reader ... • Wireless communication via Bluetooth for printer and balance Reagent dosing à la carte In a strict sense, doing titration means dosing intelli-04 gently. The Titrando System gives you the choice. With the 905 and 907 Titrando you dose with Dosinos and Dosing Units that are attached directly onto the reagent bottle. With the 904 and 906 Titrando dosing is carried out by using Exchange Units. One of these is located on the 904 or 906 Titrando, which can control additional Dosimats with their Ex change Units. Mixed systems with Dosing and Exchange Units are possible. This means that your choice doesn’t lead you down a blind alley – full flexibility is retained. The 806 Exchange Unit – a time-proven concept with added intelligence Since 1973 Metrohm has produced Exchange Units with automatic valve switching. The Exchange Unit has been continuously developed. The latest version is the 806 Exchange Unit. It dispenses reagents with a resolution of 20’000 steps per cylinder volume. The space-saving Dosino The patented Dosino with its Dosing Unit can be mount-ed directly onto the reagent bottle. This means that dosing requires no additional bench space. Thanks to adapters, any reagent bottle can be used directly. The Dosino houses the latest state-of-the-art electronics and micro-mechanics. The Dosing Unit can be exchanged within seconds. Thanks to its transparent housing any bubbles that may be present in the dosing cylinder can be seen and removed immediately and the valve position is al - ways shown. Rinsing and preparation of the Dosing Unit can be carried out automatically; manual dismantling and rinsing are not necessary. Smart dosing elements with certification The Exchange or Dosing Units set new standards with i.e. type of reagent, titer, last titer determination, shelf-05 regard to reliability. Intelligence «en miniature» in the life data and much more. In addition, the Titrando com-form of an inconspicuous Data Chip makes this possible. pares the data it has obtained with the selected method This chip is present in every 806 Exchange unit / 807 and carries out a plausibility test. If the result is negative Dosing Unit. The Titrando automatically reads from it all then a clear error message appears. the data that it needs to carry out the titration properly, Comparison of the two dosing systems 806 Exchange Unit 807 Dosing Unit Standard bottle thread GL45 GL45 Adapters for bottle threads S40, 40 mm, 32 mm, 28 mm S40, 40 mm, 32 mm, 28 mm Buret cylinders available 1, 5, 10, 20, 50 mL 2, 5, 10, 20, 50 mL Surface area needed for two dosing elements 300 mm × 240 mm 150 mm × 240 mm PCTFE/PTFE Flat stopcock made of ceramic Ceramic as an option Glass for titrants Cylinder made of Glass ETFE for auxiliary solutions and aggressive media iTrodes with 854 iConnect – the smartest sensors around 06 Metrohm iTrodes – electrodes with a brain The electrode used for the titration is the most important component of any titration system. Until now the electrode was the last gap in traceability. The Titrando with 854 iConnect now closes this gap and therefore guarantees complete traceability of the analy ti cal result to each component of the analytical system. 854 iConnect – Measuring input «on a chip» Thanks to the most advanced electronics Metrohm has been able to reduce the measuring input to the size of a postage stamp. This means that the complete measuring input fits in the electrode cable head (the 854 iConnect). It is automatically recognized and identified by its serial number. Digital data transfer The analog/digital converter in the 854 iConnect converts the analog measuring signal into binary code. Digital data transmission means that the measuring signal is no longer susceptible to electrostatic influences. Interference-free transmission can now always be guaranteed, no matter how long the electrode cable. Mobile measuring input With the 854 iConnect the electrode and the measuring input are always calibrated together. The calibration data is stored in the electrode’s head. As the measuring in put is no longer built into the instrument, the electrode (with the 854 iConnect) can be used on different titrators. The calibration procedure is no longer associa ted with a particular titrator. Digital identification – no more mix-ups 07 The built-in memory chip allows the storage of such im - If the sensor is used with different instruments or if you portant sensor data as article and serial numbers, calibra-wish to prevent inexperienced users from having to cali-tion data, calibration history, working life and calibration brate the electrode on their own instruments, then the validity period. electrode can be calibrated on a different instrument un der defined conditions. The calibration data stored in All sensor data is read in automatically when the iTrode the chip makes the electrode transferable; it does not is connected to the Titrando. Mix-ups or edit ing errors need to be recalibrated each time that it is used with a are therefore eliminated. different instrument. The electrode is identified automatically. If the type of Compatible with all existing sensors electrode is not the same as that defined in the method Despite its new digital measuring interface then the user is informed. This means that it is not pos-and intelligent sensors, the Titrando with sible to use the wrong electrode. combined analog and digital measuring input also supports conventional sensors. Storage of calibration data – outliers have no This means that you can continue to use chance all your sensors. Monitoring functions allow the exclusion of electrodes whose calibration data lies outside the limits or whose calibration period has already expired. The Titrando System at a glance 08 Thanks to its modular concept the Titrando System can Superior intelligence: The Data Chip of the Exchange Unit be adapted to any application. It meets the requirements and Dosing Unit contains all important titrant data. The of FDA Regulation 21 CFR Part 11. Benefit from the sys-intelligent sensor guarantees that no wrong or expired tem’s intelligence and multiple communication options! electrode is used. Straightforward operation: The Titrando accelerates method development and simplifies routine operation. iConnect and iTrodes – digital data transfer and automatic electrode recognition. The Data Chip of the intelligent sensors stores all important sensor data. The automatic GLP-compliant electrode test allows an 09 objective evaluation of the electrode and leaves nothing to chance. Reliable and reproducible results are therefore guaranteed. Numerous worked-out methods and titration examples guarantee ease of use. Method templates and calculation formula templates are available for developing your own methods. Safe reagent handling by either Exchange Unit or Dosing Unit. More intelligence: The Data Chip of the Exchange Unit or Dosing Unit stores all important titrant data. The 900 Touch Control provides access to the Intranet. Print your report on a network printer, save your report on a network drive or create forge-proof PDF reports – without a PC. When combining tiamo TM and Titrando, the user bene-The large color screen of the 900 fits from a client-server database. Touch Control informs the user about the instrument condition and offers Parallel titration – with tiamo TM a Titrando can work with uni quely comfortable operator guid- two titration cells at the same time. ance, including one-touch titrations via favorite icons. The Titrando System can be fully automated inclu ding sample preparation (weighing, homogenization, filt ra tion, pip etting). So smart – so easy to operate 10 Favorites for quick method start Methods can be linked to favorite icons on the touch • The «Help» fixed key shows a context-related help text screen of the 900 Touch Control. Start your titration by a in the display. single touch of an icon! • The «Follow me» help function is available when working with a PC. Continuous explanations about the Using our methods you benefit from our many years of curr ent surroundings are given in a separate window experience in titration. All titration methods developed and further possible procedures are indicated. on Metrohm Titrinos can be converted into Titrando • The standard user methods can be modified to suit methods automatically using a PC. your requirements. Method templates and calculation formula templates are available for developing your As storage media for your methods, sample data and own methods. Methods can be stored under meaning-results there are the Titrando itself, a USB memory stick ful method names (32 characters) and structured or a PC with its numerous possibilities. This provides for directories can be used; this makes sorting, identifica-complete storage security, with the prevention of meth-tion and searching much easier. od and data loss, plus an increase in operational security. • Whereas in the expert dialog all settings are available, the routine dialog can be freely configured, i.e. it can Intelligence creates transparency be customized to meet the requirements of the par-Operating the Titrando System is simple and intuitive. ticular user. This means that users can load their «pro-The operator guidance system can be regarded as exem-files» from the personal Keycard and see only those plary. In addition, the following tools provide for perfect keys that they actually need. ease of use: The Titrando puts an end to puzzling out the meaning of • The «Quick Access» function (direct parameters) allows coded error messages. It tells you what is going on in direct access to the parameters required for the given plain text. Moreover, it also suggests suitable measures application. This means that it is no longer necessary for remedying any problems. to click your way through different program levels! «Quick Access» is invaluable for routine analysis. Routine Methods can be linked to favorite icons on the starting screen of the 900 Touch Control. Titrations are started by a single touch. 11 The Titrando in the modern laboratory Data management is knowledge management Ethernet connection Data must always be available: either for direct informa-If you want to connect your Titrando System directly to a tion, for transfer to a data system, for further processing superior data system, there is nothing in the way: The or for an audit. The data that your Titrando System pro-900 Touch Control opens up internal networks (Intranet, vides you with can be printed out and stored on paper or LIMS1, LAN2) to the Titrando, with all that this implies. on a USB memory stick. Network printers can be used for printing out analysis reports. When you work with tiamo TM, you can use all the storage options offered by the digital world, for example Never has integration into your LIMS structure hard drives, network drives, servers, Intranet ... been so easy! On request the Titrando can produce a machine-readable PC/LIMS report. 1 LIMS = Laboratory Information Management System 2 LAN = Local Area Network 12 Compatibility and traceability GLP, GMP and 21 CFR Part 11 are becoming increasingly The Titrando allows strict control of access rights using important in day-to-day laboratory life. The Titrando Sys-login and password. The requirements defined in FDA tem is entirely oriented towards quality management in Regulation 21 CFR Part 11 regarding «electronic signa-the laboratory and offers the following possibilities: ture» and «electronic record» are met in the stand-alone system (using the 900 Touch Control) as well as in the • Each time that it is switched on, the Titrando System version controlled via PC (using the tiamo TM software). carries out a self-diagnosis. This also applies to the other points contained in FDA 21 • If it has been programmed accordingly, then the instru-CFR Part 11, namely the protection of electronic records ment will remind you about any validation or service against accidental or intentional alteration and complete work that is due. traceability. • You can enter limits for results; their observance will be checked for each determination. The Titrando with 900 Touch Control is the only stand- • The titer of the titrant can be monitored as a function alone titration system with audit trail. of time in both tabular form or as a graph, similar to a control card. Quality management at Metrohm • The calibration history of the sensors can be called up. Metrohm has been certified according to ISO 9001 since This means, for example, that alterations to the sensor 1993. The Metrohm quality management system is conti-caused by aging can be recognized before they affect nual y being perfected and checked by both internal and the results. external audits. • All changes to the methods are documented; traceability is guaranteed. Straightforward automation Perfect modularity 13 The possibilities for upgrading the Titrando System are amazing. First the bare figures: The basic unit consists of a Titrando with one measuring in ter face. This basic unit can be upgraded to form a super-titrator that controls 12 burets and boasts 6 galvanically separated measuring interfaces. Between these two extremes lies the whole spectrum of Titrando possibilities. Among them you will certainly find a Titrando System that meets the de mands of your particular application. Your Titrando System meets ever new and more complex challenges as it can be up - graded at any time. Automation pays dividends! Increasing sample numbers, time-consuming sample preparation steps and unattended overnight operation are good reasons for using sample changers. Your Titrando features the necessary intelligence to control sample chan gers and offers (in combination with the 814 USB Sample Processor, the 815 Robotic USB Sample Processor XL or the 898 XYZ Sample Changer) a high de gree of automation at a reasonable price. Connect the sample changer to the Titrando’s USB port and the world of automation opens up to you. Water determination with the Titrando 14 Karl Fischer titration with the Titrando Karl Fischer water determination is one of the most fre-The electrode test and the parameter «safety stop» pre-quently applied laboratory methods. In contrast to other vent the titration cell from running over during condition-water determination methods, it is specific, fast and re - ing. If, for example, the electrode is not connected quires no expensive equipment. With an application cor rectly or the titration cell is very humid, conditioning range of 0.1% to 100% water, volumetric Karl Fischer is stopped after a given time or a given volume of KF titration is used in a wide variety of fields. No matter reagent added. This feature increases work safety in your whether you determine the water content in food, cos-laboratory. metics or pharmaceutical products, the Titrando is al - ways the right instrument. The 803 KF Titration Stand Use the 803 KF Titration Stand for stirring and manual In addition to the potentiometric titration modes SET, exchange of spent titration vessel contents. With the in - DET and MET, the 906/907 Titrando systems come with te grated membrane pump, solvent can be aspirated or a special Karl Fischer mode whose sophisticated control added without the cell having to be opened. This trans-algorithm, combined with the precision of our intelligent lates into vastly reduced conditioning times. Exchange Units or Dosing Units, guarantees highly precise results. Automatic reagent change An even more comfortable option is the automatic rea-Like the other modes, the KF mode excels with easy and gent change with the 800 Dosino. You simply trigger the intuitive user guidance. Just one example: The KF icons change, which is then carried out automatically by the show you at a glance whether the instrument is still busy instrument. conditioning or whether you can start the water determination. KF reagent addition during conditioning. Conditioning is finished and the sample can be added. 15 16 STAT titration The determination of enzyme activity (lipase, trypsin, Tandem dosing etc.) or the release kinetics of antacid tablets require a Tandem dosing is a feature that prevents dosing interrup-titrator that rapidly adjusts to a preset pH value and tions when the buret is refilled during the titration – a keeps it constant for an extended period of time. The second buret immediately takes over. In this way rapid controller of the Titrando has been optimized for this task reactions with a high reagent consumption can be moni-and is one of the best on the market. It can also be used to red with maximum accuracy. Tandem dosing is also to determine the kinetics of acid-base or redox reactions. available for simple and monitored dosing. The Titrando in the synthesis laboratory In the synthesis laboratory different challenges are faced Everything under control 17 to those encountered in titration. Here a particular pH If a monitored parameter should infringe the set limits, value must be kept constant or multiple dosing has to be the user can decide whether dosing should be continued carried out under exactly defined conditions. This means or interrupted and then continued manually or automa-that a certain volume of a solution must be added within ti cally, again observing the limits. a fixed time. In addition to controlled dosing, the parameters pH (or potential) and temperature have to be con-Controller tinuously recorded, thus providing complete documenta-As an innovation the Titrando can perform control tasks. tion of the synthesis procedure. External devices can be controlled by means of freely programmable TTL signals or communication via RS 232 interface. This means that it is possible to run the external heating and cooling devices, pumps or similar equipment by remote control. Example of a neutralization process: 1. DOS Addition of 150 mL reagent in 10 min with temperature monitoring 2. Pause 5 min under stirring 3. STAT Adjust pH = 7.5 with temperature monitoring 4. SET Post reaction, for example, during 10 min; endpoint pH = 7.5 tiamo TM – titration and more! 18 tiamo TM is a control and database software for titrators, Easy data management dosing devices and sample changers that allows com-The tiamo TM database provides a wealth of tools for the plete laboratory automation. This is why the name management, searching and grouping of results. Quick tiamo TM stands for «titration and more» – tiamo TM can filters allow the user to search through thousands of do much more than just titrate. results in a matter of seconds and show the searched-for information in a clear way. Chart plots provide a rapid Easy to use overview of the chronological sequence of results. A mul ti-The modern user interface makes it easy for users to fa mi-tude of possibilities for re-calculation and re-evaluation is li arize themselves quickly with tiamo TM. All commands at the user’s disposal. and controls are located exactly where you expect them on the screen. The layout manager can be used to con-LIMS & Co. figure the screen view individually for each user. This The acceptance of PC-controlled analytical systems de - means that the users see only those windows or keys pends largely on the possibility of simple and inexpensive that are required for their work. This shortens the famil-integration in existing laboratory information systems, iarization period for routine users to a minimum. central databases and long-term archiving systems. Data generated in tiamo TM is exported in the CSV or XML for-Parallel titration mat. This enables the simple connection to most of the Both measuring inputs and all the Dosinos connected LIMS products found on the market. Analysis re ports can to a Titrando can be controlled independently of each be generated simply and flexibly with the new report other. In combination with tiamo TM this allows parallel generator, which allows the free definition of report titration of two identical or two different samples with templates. In this way one or more determinations can one single titrator. be shown at any time with a freely selectable layout in PDF format or as a paper printout. tiamo TM means more efficiency All requirements met 19 The graphical method editor gets more out of your tiamo TM also sets new standards regarding compliance titration system. Methods can be drawn up easily and with GMP, GLP and FDA requirements. tiamo TM has been quickly by using the numerous templates. You can pro-consistently oriented to comply with FDA Regulation gram and link actions that are to be carried out simul-21 CFR Part 11 and its customer-specific interpretations. taneously. tiamo TM is flexible and adapts itself to your analytical sequences – not the other way around. Technical specifications 20 904 Titrando 905 Titrando 906 Titrando 907 Titrando Dosing elements 1 integrated Space for two 1 integrated Space for two Dosimat with 800 Dosinos with Dosimat with 800 Dosinos with 806 Exchange Unit 807 Dosing Unit 806 Exchange Unit 807 Dosing Unit Attachment of additional dosing Up to 9 x 805 Dosimat with 806 Exchange Unit elements Up to 12 x 800 Dosino with 807 Dosing Unit Intelligent Exchange Unit/Dosing yes Unit with integral Data Chip Dosing steps per cylinder volume 904 Titrando 905 Titrando 906 Titrando 907 Titrando (resolution) with 805 Dosimat: with 800 Dosino: with 805 Dosimat: with 800 Dosino: 20'000 10'000 20'000 10'000 Operation, dialog Touch Control or tiamo TM Stirrers, titration stand 4 × 801 Magnetic Stirrer or 4 × 802 Rod Stirrer with 804 Titration Stand or 803 KF Titration Stand Attachment of Dosimats, Dosinos, 4 MSB connectors (Metrohm Serial Bus, Daisy Chain) stirrers Sample Changer attachment 1 sample changer via USB Attachment of balances, printer, Via 2 USB Slave Ports, RS-232/USB Box (option) PC, PC keyboard, barcode reader Attachment of additional measur- ing modules (867 pH Module yes or 856 Conductivity Module) Temperature sensor Pt 1000 or NTC Differential amplifier Option Real-time curve display on Touch Control (90 mm × 120 mm) yes or PC screen DET Dynamic Equivalence-point yes Titration MET Monotonic Equivalence- yes point Titration SET Titration to a preset end- point with automatic yes conditioning KF Volumetric Karl Fischer titration with automatic no yes conditioning STAT Titration to a preset control point and maintaining the no yes corresponding measured value MEAS Measuring mode for pH, Resolution: 0.001 pH, 0.1 mV, 0.1 °C; U/mV, T/°C Measuring interval: 100 ms MEAS CONC Direct measurement using ISE and calculation of yes concentration CAL Calibration with automatic yes buffer recognition 904 Titrando 905 Titrando 906 Titrando 907 Titrando 21 Second, galvanically separated measuring interface for pH, Option U/mV, T/°C I & U – integrated pol pol yes programmable Polarizer Additional possibilities of titration-curve evaluation: fixed endpoints, pK values (HNP), yes minimum/maximum, break point (photometry or conductometry) Sequences can be freely yes programmed by the user Method and sample data memory, yes result memory, data base Dialog languages 900 Touch Control: English, German, Spanish, French, Chinese, Portuguese, Russian, Korean, Polish, Italian yes Dialogue languages tiamo TM: German, English, Spanish, French, Chinese, traditional Chinese, Portuguese, Russian, Slovakian, Italian Comprehensive GLP functions; meets requirements of yes FDA 21 CFR Part 11 Intelligent dosing devices yes Intelligent electrodes «iTrodes» yes GLP-compliant electrode test yes Check for result limits yes Access control by means of login with password protection; yes Electronic Signature Liquid handling with expanded dosing instructions for the yes 800 Dosino 22 Ordering information 904 Titrando 2.904.0010 904 Titrando with built-in buret drive and one combined analog/digital measuring input 2.904.0020 904 Titrando with built-in buret drive and two combined analog/digital measuring inputs 905 Titrando 2.905.0010 905 Titrando with one combined analog/digital measuring input 2.905.0020 905 Titrando with two combined analog/digital measuring inputs Moreover, the 905 Titrando is available with several different packages focusing on the requirements of particular industries. Each package includes everything im terms of instrument, accessories, and applications to meet the needs of the respective industry. Besides tiamo TM light this includes a compilation of methods described in detail as well as the complete accessories for your titrations. More information is available from www.metrohm.com 906 Titrando 2.906.0010 906 Titrando with built-in buret drive and one combined analog/digital measuring input 2.906.0020 906 Titrando with built-in buret drive and two combined analog/digital measuring inputs 907 Titrando 2.907.0010 907 Titrando with one combined analog/digital measuring input 2.907.0020 907 Titrando with two combined analog/digital measuring inputs Options 2.800.0010 800 Dosino for 905 and 907 Titrando and as additional dosing device for 904 and 906 Titrando 23 2.801.0040 801 Magnetic Stirrer 2.802.0010 802 Rod Stirrer 2.803.0010 803 KF Titration Stand 2.804.0040 804 Ti Stand 2.805.0010 805 Dosimat as additional dosing device for 904 and 906 Titrando (and 905 and 907 Titrando) 2.854.0010 854 iConnect for connection of intelligent electrodes «iTrodes» 2.846.0010 846 Dosing Interface as extension for four additional Dosing Elements 2.856.0010 Conductivity Module as additional measuring input for conductivity measurements 2.867.0010 pH Module as additional measuring input for pH measurements 2.900.0010 900 Touch Control 6.2148.010 Remote Box MSB 6.2148.020 RS-232/USB Box 6.2151.000 Cable USB A plug – Mini-DIN plug, 8 pins 6.2151.010 Extension cable Mini-DIN socket – Mini-DIN plug, length 2 m 6.2151.020 Cable USB A plug – USB B plug, length 1.8 m 6.2151.030 Cable USB A plug – USB B plug, length 30 cm 6.5104.030 Differential amplifier equipment with line adapter 230 V, EU plug 6.5104.040 Differential amplifier equipment with line adapter 115 V, US plug 6.2061.010 Reagent Organizer, holds two 1 L bottles; for dosing with Dosinos and Dosing Units Intelligent 807 Dosing Units for 800 Dosino; equipped with Data Chip; with glass cylinder, including accessories and two buret tips, one of them with micro outlet valve 6.3032.120 Intelligent Dosing Unit 2 mL 6.3032.150 Intelligent Dosing Unit 5 mL 6.3032.210 Intelligent Dosing Unit 10 mL 6.3032.220 Intelligent Dosing Unit 20 mL 6.3032.250 Intelligent Dosing Unit 50 mL Intelligent 806 Exchange Units for 904/906 Titrando and 805 Dosimat; equipped with Data Chip; with glass cylinder and flat PCTFE/PTFE stopcock 6.3026.110 Intelligent Exchange Unit 1 mL 6.3026.150 Intelligent Exchange Unit 5 mL 6.3026.210 Intelligent Exchange Unit 10 mL 6.3026.220 Intelligent Exchange Unit 20 mL 6.3026.250 Intelligent Exchange Unit 50 mL www.metrohm.com G, CH-9100 Herisau ohm A witzerland by Metr , printed in S SW 11 Subject to change Layout by Ecknauer+Schoch A 8.904.5001EN – 2013-