TitrIC Vario pro Multi parameter analysis by titration and ion chromatography combined TitrIC Vario pro – the dream team for comprehensive ion analysis Comprehensive analysis of ionic components in liquid 02 It is good to know that there is a way to do it much samples such as water involves four analytical techniques: easier, faster, and more reliably, too: TitrIC. TitrIC stands for direct measurement, titration, and ion chromatography • Direct measurement combined in a single system. Ever since Metrohm intro- • Titration duced the first TitrIC system in 1998, it was constantly • Ion chromatography developed further. • Voltammetry With TitrIC Vario pro we are proud to present the most Each of these techniques has its particular strengths. flexible, reliable and easy to use TitrIC system ever. However, applying them one after the other on discrete systems is a rather complex task that takes its time. Highlights • Unique combination of titration, direct measurement and ion chromatography 03 • Minimum space required • Fully automated analysis of all ionic components • Easy to control with MagIC Net software • Use titration or ion chromatography alone or both techniques combined • All analytical results in one report • Fast analysis, reliable and reproducible results • Unique calculation of the ionic balance • Cost efficient • State-of-the-art database for storage and management of results • Just one sample changer needed for three analytical techniques • Fully compatible with Metrohm Inline Sample Preparation (MISP) techniques • TitrIC Vario pro is FDA compliant Application areas of TitrIC Vario pro • Municipal water authorities • Desalination plants • Environmental institutes • Food industry • Pharmaceutical industry • Metal working industry • Automotive industry • ... TitrIC Vario pro – the details 04 Highly flexible TitrIC Vario pro is hard to beat when it comes to flexibi-lity. The system can be upgraded at any time with unique, time and work saving accessories for Inline Sample Pre - Easy to use paration, e.g. for Inline Dilution. Whether sequential, chemical or without suppression, TitrIC Vario pro allows for fully automated, unattended Furthermore, many additional features and parameters operation from the moment you have filled in the deter-can be added and determined, respectively. mination table. TitrIC Vario pro is self-monitoring. The system tells you when it is time to calibrate the electrodes, determine the titer, and when to change the so - lutions. If any system parameter is out of spec, TitrIC lets you know by an error message sent to your mobile or e-mail account. On your command, the system is shut down im mediately. Perfect reliability TitrIC Vario pro automatically injects check standards after any number of samples defined by the user. The system is automatically recalibrated, if any check is out of specs. Complete traceability Results of titration, direct measurement, and ion chromatography are available in user-defined reports. All data generated can always be reviewed; complete traceability is guaranteed so you are prepared for even the toughest audits. You decide what to do It is always yours to decide for each sample whether to do just a titration and determine conductivity, only use ion chromatography, or whether to run the full program including ion chromatography. It is easy. In the sample table, simply use the drop-down menu and mark for each sample what you would like to do. 05 Made to measure If any Metrohm methods and/or instrumentation are al - ready being used in your lab, there is no need for you to spend extra money. We will find a way to integrate them and get the most out of your Metrohm instruments and methods. 06 TitrIC Vario pro – numerous possibilities in ion analysis ... ... through the unique combination of titration and ion chromatography TitrIC Vario pro combines the three analytical methods Particular attention has been given to keeping space titration, direct measurement and ion chromatography re quirements to a minimum. TitrIC Vario pro profits from (IC) in a unique system that only Metrohm is able to offer. the syner gies between titration, direct measurement and Metrohm‘s experience in both titration and ion chroma-ion chromatography, all made by Metrohm. All the meth-tography has resulted in a complete system that can be ods use the same liquid handling units and a common used for many different kinds of analysis. All ionic com-sample changer. This helps to save both costs and bench ponents are determined rapidly, reliably and reproducibly. space – a rapid return on investment is assured. The results are stored in the integral database and processed into a single report. Flexibility for a wide variety of application areas The combination of the extremely flexible MagIC Net Automation saves money software with tiamo TM allows the performance of any TitrIC Vario pro is completely automated. After the sam-titration or direct measurement as well as any type of ples have been placed on the rack, MagIC Net takes over anion or cation determination by IC. This is why TitrIC and can work seven days a week for 24 hours per day. Vario pro is not only the system of choice for water Intelligent control and thoroughly tested technology analysis but is also ideal for applications in the foods, gu a rantee reliable analyses. Up to 100 samples can be electroplating, automotive and pharmaceutical indus-determined without any manual intervention. The high tries. degree of automation reduces costs and increases the precision of the analysis. Sample changer Conductivity Anions Temperature Cations pH value Titration K 8.2 (p value) a Titration K 4.3 (m value) a Database TitrIC Vario pro determines the following parameters Direct measurements with TitrIC Vario pro Cation IC with TitrIC Vario pro 07 • pH value • Lithium • Temperature • Sodium • Conductivity • Ammonium • Potassium Titrations with TitrIC Vario pro • Calcium • p value (titration to pH = 8.2) • Magnesium • m value (titration to pH = 4.3) • ... • Calcium • Magnesium Calculations with TitrIC Vario pro • ... • Molar concentrations of all cations • Molar concentrations of all anions Anion IC with TitrIC Vario pro • Ionic balance • Fluoride • Total water hardness • Chloride • ... • Bromide • Nitrite • Nitrate • Phosphate • Sulfate • ... TitrIC Vario pro – the customized analytical system 08 TitrIC Vario pro can be adapted to suit any analytical requirement. The application determines the parameters of inter est. This means that different methods and procedures can be combined. TitrIC Vario pro is available in three main versions. TitrIC Vario pro I – the basic system 815 Robotic USB Sample Processor XL Fully automated system for direct measurement of tem-28...100 samples, 75...250 mL perature, conductivity and pH value, the titrimetric determination of the p and m values, calcium and magnesium, and the ion chromatographic determination of anions. Conductivity Titration K 8.2 (p value) A Anions Temperature Titration K 4.3 (m value) A F–, CI–, NO –, Br–, NO –, 2 3 HPO 2–, SO 2– Titration Ca2+ 4 4 pH value Titration Mg2+ MagIC Net Database, Report TitrIC Vario pro I: The system consists of an 856 Conductivity Module, four 800 Dosinos, an 802 Stirrer, a 905 Titrando, an 815 Robotic USB Sample Processor XL and an 930 Compact IC Flex with sequential suppression. 09 TitrIC Vario pro II – for complete anion and cation 815 Robotic USB Sample Processor XL analysis 28...100 samples, 75...200 mL Fully automated system for the direct measurement of temperature, conductivity and pH value, the titrimetric determination of p and m values, the ion chromato-Conductivity g raphic determination of cations including calcium and Anions Cations Temperature F–, CI–, NO –, Br–, NO –, Li+, Na+, NH +, K+, 2 3 4 mag nesium, as well as the ion chromatographic determi-HPO 2–, SO 2– Mg2+, Ca2+ 4 4 pH value nation of anions. Titration K 8.2 (p value) A Titration K 4.3 (m value) A MagIC Net Database, Report TitrIC Vario pro II: The system consists of an 856 Conductivity Module, two 800 Dosinos, an 802 Stirrer, a 905 Titrando, an 815 Robotic USB Sample Processor XL, and two 930 Compact IC Flex. 10 TitrIC Vario pro III – the professional solution 815 Robotic USB Sample Processor XL 28...1000 samples, 75...200 mL with sealed sample vessels DisCover Fully automated system for the direct measurement of temperature, conductivity and pH value, the titrimetric determination of p and m values and the ion chromatog-Conductivity raphic determination of cations including calcium and Anions Cations Temperature F–, CI–, NO –, Br–, NO –, Li+, Na+, NH +, K+, 2 3 4 magnesium, as well as the ion chromatographic determi-HPO 2–, SO 2– Mg2+, Ca2+ 4 4 pH value nation of anions. The sample changer is equipped with Titration K 8.2 (p value) A the DisCover function for the automatic removal of the Titration Titration K 4.3 (m value) 4 3 (m al e) covers from the sealed sample vessels. A MagIC Net Database, Report TitrIC Vario pro III: The system consists of an 856 Conductivity Module, two 800 Dosinos, an 802 Stirrer, an 905 Titrando, an 815 Robotic USB Sample Processor XL and an 940 Professional IC Vario for anions and cations. Flow charts for the three main TitrIC Vario pro systems In the left block the titration part is depicted, in the 11 middle rectangle the liquid handling is shown, and on the right the IC part can be seen. TitrIC Vario pro I: The sample path is split after the sample changer to feed the titration side and the ion chromatography side separately with the help of an 800 Dosino. Ca2+ & Mg2+ analysis completes the alkalinity, pH, conductivity, and temperature mea surements performed by titration. Standard anions are measured with sequential suppression and IC conductivity detection. TitrIC Vario pro II: The sample path is split after the sample changer to feed the titration side and the ion chromatography side separately with the help of an 800 Dosino. Alkalinity, pH, conductivity and temperature measurements are performed with titration. Standard anions are measured after sequential suppression, cations directly by IC conductivity detection. TitrIC Vario pro III: The sample path is split after the sample changer to feed the titration side and the ion chromatography side separately with the help of an 800 Dosino. Alkalinity, pH, conductivity and temperature measurements are performed by titration. Standard an ions are measured after sequential suppression, ca tions directly by IC conductivity detection. To protect the samples from contact with the ambient air, the sample vessels are covered with a magnetic cap that is removed only shorty before analysis. 12 TitrIC Vario pro – upgrade kits TitrIC Vario pro can easily be upgraded with predefined the conductivity value is measured during the transfer of accessory kits for Metrohm logical Inline Dilution or the sample into the titration vessel. Metrohm intelligent Partial Loop Injection Technique (MiPT). Logical Inline Dilution not only allows the analysis of a wide range of sample concentrations without the need TitrIC Vario pro: Dilution Kit (6.5338.100) of any manual intervention but also the performance of Metrohm logical Inline Dilution provides for accurate a multi-point calibration from a single multi-ion standard. results while saving the user from manual sample preparation. First, the conductivity of the sample is measured. From the measured value, a dilution factor is calculated For Metrohm logical Inline Dilution, TitrIC Vario automatically by the MagIC Net software. The sample is pro has to be ordered with the TitrIC Vario pro then diluted accordingly in an external vessel, guarantee-Dilution Kit and additionally an 800 Dosino, an ing results within the calibration range with just a single 741 Magnetic Stirrer and, in some cases, an 804 injection of sample. Moreover, no sample is wasted as Ti Stand. TitrIC Vario pro I: Setup with added MiPT Kit TitrIC Vario pro: MiPT Kit (6.5338.110) With Metrohm intelligent Partial Loop Injection Technique (MiPT) it is possible to inject different sample volumes with just one fixed injection loop. MiPT enables analyzing a wide range of sample concentrations, and performing a multi-point calibration from just one multi-ion standard is possible. For MiPT, TitrIC Vario pro has to be ordered with the TitrIC Vario pro MiPT Kit and additionally an 800 Dosino. Typically, the MiPT method is used for analysing compo-For both techniques, a measuring range of 1:10'000 is achieved; nents at µg/L-mg/L levels, while the sample is diluted from just a single standard! when dealing with higher (mg/L-%) con centrations. TitrIC Vario pro – software solution As titration and ion chromatography are two entirely dif-The full potential of MagIC Net can be used and all func-09 13 ferent techniques, it is difficult to combine both in one tions are available for reprocessing and recalculating of and the same software. We have met this challenge the IC results. Titration results are simply transferred to with a most elegant solution. TitrIC Vario pro is control-the corresponding determination in MagIC Net and are led by Metrohm’s standard software for ion chromato-thus available in the database. The complete data are graphy, while the software for titration is running in the avail able for professional data management and are FDA background. compliant. Results are shown in one and the same table for both systems and a joint report is given out at the end. To be more precise, in TitrIC Vario pro, MagIC Net controls tiamo TM. This brings virtually unlimited versatility to TitrIC Both softwares is available in several different languages. Vario pro, as any MagIC Net method can be combined with any tiamo TM method. In other words, you do your daily work with MagIC Net, which serves as the master software, while tiamo TM is running in the background as a slave. Example report of a TitrIC Vario pro system Ordering information 14 a.) Main packages TitrIC Vario pro I The basic TitrIC Vario pro system. Anion concentrations are determined via ion chromatography; alkalinity and calcium and magnesium concentrations by titration. Direct analysis of conductivity, pH and temperature of the samples are also included. TitrIC Vario pro II The advanced TitrIC Vario pro system. Anion and cation concentrations are determined via ion chromatography; alkalinity by titration. Direct analysis of conductivity, pH and temperature of the samples are also included. TitrIC Vario pro III The high-end version of a TitrIC Vario pro system. Anion and cation concentrations are determined via ion chromatography with the 940 Professional IC Vario system; alkalinity by titration. Direct analysis of conductivity, pH and temperature of the samples are also included. As a further improvement, the sample changer is equipped with the DISCOVER function, where a magnetic cap covers the vials, to prevent the solutions from evaporating and/or absorbing CO , which would result in a changed pH value. Only right before the analysis 2 the cap is removed automatically. b.) Accessories Sample racks 6.2041.800 Sample rack 100 × 75 mL1 6.2041.810 Sample rack 34 × 150 mL1 6.2041.820 Sample rack 28 × 250 mL1 6.2041.830 Sample rack 28 × 200 mL 6.2041.840 Sample rack 59 × 120 mL Sample beakers 6.1432.210 Sample beaker 75 mL made of glass (for 6.2041.800)1 6.1432.320 Sample beaker 250 mL made of glass (for 6.2041.820)1 6.1432.250 Sample beaker 250 mL made of polypropylene (for 6.2041.820)1 6.1459.300 Sample beaker 120 mL made of polypropylene (250 pieces) (for 6.2041.840) Electrodes 6.0277.300 iAquatrode plus with Pt 10002 6.0510.100 Combined polymermembrane electrode Ca3 6.0915.100 Five-ring conductivity measuring cell, c = 0.7 cm–1, with Pt 10002 Separation columns 6.1006.510 Metrosep A Supp 5 - 100/4.0 6.1006.520 Metrosep A Supp 5 - 150/4.0 6.1006.500 Metrosep A Supp 4/5 Guard/4.0 6.1030.410 Metrosep A Supp 15 - 100/4.0 6.1030.420 Metrosep A Supp 15 - 150/4.0 6.1030.500 Metrosep A Supp 15 Guard/4.0 6.1050.410 Metrosep C 4 - 100/4.0 6.1050.420 Metrosep C 4 - 150/4.0 6.1050.500 Metrosep C 4 Guard/4.0 Suppressor rotors 15 6.2832.000 MSM Rotor A 6.2842.000 MSM-HC Rotor A 6.2844.000 MSM-LC Rotor A 6.2842.200 MSM-HC Rotor C 6.2842.020 Adapter Vario to MSM and MSM-LC c.) Optional accessories Additional kits for IC 6.5338.100 TitrIC Vario pro: Dilution kit Has to be ordered with an 2.800.0010 Dosino, an 2.741.0010 Magnetic Stirrer and an 2.804.0010 Ti-Stand for the TitrIC Vario pro I and II versions. For TitrIC Vario pro III, only the 2.800.0010 and 2.741.0010 have to be ordered. 6.5338.110 TitrIC Vario pro: MiPT kit Has to be ordered with an 2.800.0010 Dosino. Inline Eluent Preparation 2.941.0010 941 Eluent Production Module 2.800.0010 800 Dosino 6.5330.090 IC Equipment: Additional Eluent on the Eluent Production Module 6.2769.110 Sensor EMPTY for 2 L bottles Titration equipment 6.2307.230 Buffer solutions pH 4, 7, and 92 6.2324.000 Conductivity standard 500 mL (100 µS/cm)2 6.2301.060 Conductivity standard (12.88 mS/cm) 6.2065.000 Stacking frame for 846 Dosing Interface. 856 Conductivity Module, 905 Titrando 1 Suitable for the DIS-Cover function of TitrIC Vario pro III 2 Included in the delivery package of TitrIC Vario pro I, II, and III 3 Included in the delivery package of TitrIC Vario pro I www.metrohm.com Herisau CH-9100 AG, Metrohm by Switzerland printed in 8 ASW, Layout 2015-0 Ecknauer+Schoch Subject to change by 8.000.5138EN –