MILESTONE H E L P I N G C H E M I S T S AT MILESTONE WE HELP CHEMISTS Milestone Product Portfolio MILESTONE H E L P I N G C H E M I S T S Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China, Japan and Korea. We operate worldwide through a network of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible. Microwave Sample Preparation for trace element analysis Acid Purification and Cleaning Solutions for trace metals analysis Direct Mercury Analysis of samples Microwave Extraction Systems for environmental, food and natural products Microwave Muffle Furnace for QC testing Microwave Synthesis Tools for researchers OUR CAPITAL OUR PEOPLE YOUR EXPERTS QUALITY ANALYSIS STARTS WITH GREAT SAMPLE PREP ULTIMATE EASE OF USE AND CONTROL Sample preparation is one of the most important steps in metals and trace metals determination, as it feeds the AAS/ ICP/ ICP-MS. Inherently the analysis quality is directly reliant on the sample preparation step. The ETHOS UP and ETHOS EASY fully embody Milestone’s philosophy and knowledge in microwave sample preparation. Specifically designed for closed-vessel acid digestions, they offer a perfect integration UNRIVALLED PERFORMANCE of microwave hardware, user interface, reaction AND THROUGHPUT sensor technology and pressure resistant vessels. The EasyTEMP contactless sensor directly controls the temperature of all the samples and solutions, providing accurate temperature feedback in order to ensure a complete and safe digestion in all the vessels. The ETHOS UP and ETHOS EASY user-interface fully controls all digestion parameters, provides complete documentation and expedites the overall digestion procedure. The SK-15 and MAXI-44 rotors ensure EXPERTISE a high performance and a high sample throughput, AND KNOW-HOW whereas the user-friendly design simplifies the digestion process. ETHOS UP High Performance Microwave Digestion System SUPERIOR SAFETY AND RELIABILITY ETHOS EASY Advanced Microwave Digestion System FLEXIBILITY Agriculture Beverage Ceramics Chemicals Clinical Cosmetics Environmental Food & Feed Petrochemical Officials Pharmaceutical Pigments Polymers Geochemistry Metals SUPERIOR THROUGHPUT, QUALITY & ROI THE GAME CHANGER IN MICROWAVE SAMPLE PREP The ultraWAVE fully endorses our vision in microwave MARKET-LEADING sample preparation. It exceeds norms and breaks INNOVATION conventions. It is incredibly easy to use, cost-effective, quick to adopt and fast to implement. The ultraWAVE has already transformed and enhanced the way analytical chemists prepare their samples for trace metal analysis in hundreds of laboratories all over the world. The ultraWAVE is based on Single Reaction Chamber (SRC) technology, invented (Patents pending) by Milestone several years ago. The high-INCREASED performance stainless steel chamber allows for higher PRODUCTIVITY pressures and temperatures to be reached and any type of acids to be used. Disposable vessels eliminate the need to assemble, disassemble or clean between processing. Just as important, dissimilar samples can be processed simultaneously using any mixture of disposable glass, quartz or TFM vials, thus saving time and money. The ultraWAVE is simply the fastest, easiest and most efficient digestion system ever made! ULTIMATE EASE OF USE ultraWAVE Single Reaction Chamber Microwave Digestion System UNMATCHABLE PERFORMANCE GREATER RETURN ON INVESTMENT Agriculture Beverage Ceramics Chemicals Clinical Cosmetics Environmental Food & Feed Petrochemical Officials Pharmaceutical Pigments Polymers Geochemistry Metals OPTIMIZING ANALYTICAL PERFORMANCE IN TRACE ELEMENT ANALYSIS LOWER The Milestone Clean Chemistry Line is an innovative ANALYTICAL BLANKS and complete portfolio of systems and accessories for reducing and controlling the analytical blank in ultra-trace elemental analysis. There is a growing awareness that sample preparation should evolve to the same standards of the most modern analytical techniques, such as ICP-MS, and there are several factors that can critically impact the quality of the data: IMPROVED • The purity of the reagents. DETECTION LIMIT • The cleanliness of the material in contact with the sample. • The sample preparation method. Each of these factors is related to the reduction and the control of the analytical blank. To address this issue, Milestone has developed a comprehensive line of products and accessories aimed to reduce and control 90% REAGENT the analytical blank, which perfectly complement our COST SAVINGS microwave digestion line. duoPUR Quartz Acid Purification System subCLEAN PTFE Acid Purification System HIGH PRODUCTIVITY traceCLEAN Automated Acid Steam Cleaning System ON-DEMAND ACID PURIFICATION duoPUR The duoPUR consists of two quartz purification units, containing two heating elements, a water-cooled condenser, a high-purity PFA collection bottle, and a fully automatic acid loading/ discharge system. The purification rate ranges from 50 to 400 mL per hour, depending on the power setting and the temperature of the cooling water. subCLEAN Milestone's subCLEAN sub-boiling system is compact and easy to use. All parts that have contact with acids are made of high quality fluoropolymers. The subCLEAN is suitable for the purification of HF, as well as for HNO and 3 HCl. The subCLEAN rapidly condensates acid vapors into a collection bottle by forced cooled air. traceCLEAN Cleaning the accessories used in ultra-trace analysis is a critically important. To address this need, Milestone has developed the traceCLEAN, a fully automated and self-contained acid steam cleaning system that cleans accessories used in trace metal analysis. Freshly distilled acid vapors continuously reflux within the sealed unit, thoroughly leaching any metal contaminants from vials, microwave digestion vessels, flasks, glassware and ICP-MS accessories. SAVE TIME GO DIRECT INDUSTRY LEADING PERFORMANCE FOR MERCURY ANALYSIS The Milestone DMA-80 evo has been at the forefront of direct total mercury analysis for almost two decades. The challenges in mercury determination are well known to analysts who have often had to face a number of issues due to either tedious sample preparation process or different analysis steps. The DMA-80 evo UNPARALLELED analyzes any matrix (solid, liquid or gas) without any EASE OF USE pre-treatment or chemical additions in as few as 5 minutes. We are, and have been, the benchmark for direct mercury determination in many industries, including: environmental, food, energy, cement, cosmetics, agriculture, mining and petrochemical. With thousands of DMA-80s installed in over 80 countries, Milestone has a wealth of experience and knowledge regarding direct mercury determination, ensuring your HIGH PRODUCTIVITY AND laboratory's state-of-the-art technology and premium customer support. EFFICIENCY DMA-80 evo Direct Mercury Analyzer DMA-1 Direct Mercury Analyzer LOW RUNNING AND MAINTENANCE COSTS IMPRESSIVE APPLICATION FLEXIBILITY Environmental Food & Feed Power plants/Coal Cement/Mining Clinical/Biological Petrochemical INNOVATIVE & EASY TO USE EXTRACTION SOLUTIONS TO MAXIMIZE LAB WORKFLOW Solvent extraction is the least evolved and most error-SHORTER prone step in chromatographic analytical procedures. EXTRACTION TIME Many laboratories still use the Soxhlet method that was developed in 1879. Microwave-assisted extraction uses closed vessels to heat the extraction solvent above its atmospheric boiling point. The elevated temperature of the solvent increases the solubility of the analyte of interest, leading to dramatically reduced extraction times. Microwave extraction is faster and produces more accurate and precise results than LOW other methods. Typical applications of microwave-RUNNING COSTS assisted solvent extraction include: contaminates from environmental matrices, total fat determination in food samples and extraction of flavors and fragrances from natural products. ETHOS X Advanced Microwave Extraction System ENHANCED EASE OF USE for GC and HPLC Analysis for Environmental Applications for Green Extraction of Natural Products for Total Fat Determination in Foodstuff LOW SOLVENT CONSUMPTION CONSISTENT AND RELIABLE RESULTS Environmental The Milestone ETHOS X microwave lab station in combination with our fastEX-24 rotor offers your laboratory the simultaneous extraction of 24 samples in 40 minutes with minimal solvent usage using disposable glass vials. Our unique WeflonTM material provides homogeneous heating and facilitates the accurate contactless temperature monitoring of all vessels. Environmental Total Fat Traditional fat extraction methods are labor-intensive, time-consuming and involve large solvent volumes. The ETHOS X allows the simultaneous total fat determination of 12 samples in just 90 minutes. In addition to higher productivity, the ETHOS X also reduces the solvent consumption and uses a single method for a wide variety of samples. Food & Feed Natural Products The ETHOS X for Microwave Green Extraction of Natural Products overcomes all the limitations of traditional steam and hydro-distillation. The plant material is placed into the dedicated glass reactor and essential oils are extracted in a few minutes. The whole process is done without any solvent, providing high efficiency, higher extraction quality and reducing the overall extraction cost. Cannabis Food & Feed Cosmetics Academia SAFE, REPRODUCIBLE AND FAST ASHING FOR HIGH PRODUCTIVITY LABS FAST ASHING IN MINUTES INSTEAD OF HOURS The Milestone PYRO is an advanced microwave muffle furnace, suitable for several applications such as ashing, sulfated ashing, loss on ignition (LOI), residue on ignition (ROI), fusion and, all high temperature reactions under controlled conditions. The PYRO is available in 3 different and interchangeable configurations: ultrafast heating setup, high sample throughput setup and sulfated ashing setup. Therefore, it is the most flexible HIGH SAMPLE and adaptable microwave muffle furnace available in the market. THROUGHPUT PYRO Advanced Microwave Muffle Furnace for High Sample Thoughput for UltraFAST Heating IMPROVED WORKING CONDITIONS for Sulfated Ashing FLEXIBLE CONFIGURATIONS ASTM, USP, SEMI AND ISO COMPLIANCE High Sample Throughput The PYRO with the High Sample Throughput setup ensures superior throughput, as the combination of microwave “superheating” and induced airflow results in a dramatic reduction of the ashing time. The ashing process is fully controlled by a precise and accurate thermocouple that provides constant feedback to the easyCONTROL software, which provides full data traceability. Pharmaceutical Food & Feed Polymers Petrochemical Ultrafast Heating The PYRO with the Ultrafast Heating setup provides unmatchable heating, as it reaches 800° C in just 5 minutes. The temperature is monitored and controlled via a contactless infrared sensor. The incredibly fast heating rate of this PYRO setup, combined with the properties of the Milestone UltraFAST crucibles, ensures ashing in literally in minutes. Food & Feed Petrochemical Polymers Sulfated Ashing The PYRO, with the Sulfated Ashing setup, completely removes hazardous operations on the heating blocks and performs the complete sulfated ashing procedure in one hour. Acid fumes are safely condensed and neutralized through a dedicated scrubber, while the easyCONTROL software provides complete control in full compliance with 21 CFR parts 11. Pharmaceutical Petrochemical M A X I M I Z I N G YOUR RESEARCH WITH FLEXIBLE TOOLS UNPARALLELED FLEXIBILITY Microwave technology is changing the way of designing and optimizing synthetic protocols as well as their scaling up to multi-gram production. Since its introduction, it has allowed faster experiment runs and higher yields. Today, microwave assisted synthesis has become a cutting-edge technology across the pharmaceutical, biotech, polymers, fine and agro-chemical industries. With units installed worldwide, GREATER Milestone's flexiWAVE is a single microwave platform EASE OF USE that, in combination with specific accessories, allows the chemists to perform classic glassware and high-pressure synthesis, as well as solid-phase reactions. Milestone's synthWAVE is designed for a safe, reliable and reproducible scale-up of microwave enhanced chemical reactions. It handles single or multiple reactions at temperatures of up to 300 °C and pressures of up to 199 bar. Incredibly easy to use, the EASY synthWAVE allows small to large-scale batch runs and SCALE-UP parallel reactions at conditions never explored before. flexiWAVE Advanced Flexible Microwave Synthesis Platform synthWAVE FASTER The Game Changer SCREENING in Microwave Synthesis SUPERIOR PERFORMANCE Academia Beverage Carbon nanotubes Ceramics Chemicals Cosmetics Environmental Food & Feed Medical Metals Petrochemical Pharmaceutical Pigments Polymers MEETING REGULATIONS: M I L E S T O N E ' S VALIDATION P A C K A G E The compliance with regulations and data traceability are important values in modern analytical laboratories HIGH QUALITY ENSURED of pharmaceutical, food and other regulated industries. GMP COMPLIANT The qualification of the instruments and of their related methods into these industries often goes through COST-EFFECTIVE multiple steps in order to ensure that the instrument meets these regulations. Milestone, as a leading EXPERTISE AND KNOW-HOW technology and solution provider in microwave sample preparation, provides comprehensive Milestone RELIABLE RESULTS Validation Packages (MVP) that meet these needs. MILESTONE C O N N E C T 30 YEARS OF EXPERIENCE AT YOUR FINGERTIPS Milestone Connect is a unique feature for your best-in-class system that puts Milestone's 30-year applications REMOTE MONITORING experience at your fingertips. With the ETHOS UP, VIDEO TUTORIALS ETHOS EASY, UltraWAVE and DMA-80 evo, comes exclusive access to Milestone's Application Team via APPLICATIONS LIBRARY continuously updated application notes, a library of scientific papers, video tutorials and system manuals QUICK GUIDE available 24/7. Milestone Connect remotely monitors the operation of the microwave digestion system or MANUALS AND DOCUMENTATION direct mercury analyzer through desktop, tablet or smartphone, greatly enhancing process control of sample preparation and analysis procedure. MILESTONE YOUR REALIABLE PARTNER Today, the choice of the right instrument for your lab includes the selection of the right partner. Milestone has always been a user-centric company since its foundation in 1988. Our priority is to offer our users a superior overall experience, from our professionalism and expertise to our products and technology. Our corporate and local teams are highly trained in applications and service in order to guarantee fast and reliable support. We will assist you throughout the whole process, suggesting the right solution for your needs, developing dedicated applications and ensuring we meet your expectations. Our premium service support, along with the reliability of our products, minimizes laboratory's downtime and maximizes your efficiency. 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