MILESTONE H E L P I N G C H E M I S T S MAXIMIZE YOUR CANNABIS TERPENE PROFILE ETHOS X: Solvent-Free Terpene Extraction Solutions M I L E S T O N E ETHOS X T H E G R E AT E S T EFFICIENCY WITH THE HIGHEST Q U A L I T Y Multiple US states, along with other countries, permit the use of cannabis for medicinal and recreational use, greatly increasing the market for cannabis-related products. THC, CBD and terpenes are the major target compounds in the cannabis plant. Although there are several technologies available to extract THC and CBD, they are not designed to selectively extract terpenes, and thus often lead to loss, damage or only partial extraction of these molecules. Terpenes from cannabis plants are extremely valuable as they are responsible for the strain-specific variation in smell, taste, and effects of cannabis. Due to their unique flavor, they are widely used as ingredients for multiple end-products, such as vape pens and edibles, just to mention a few. Terpenes are also used in the medicinal field as they exponentially increase the effectiveness of THC and CBD molecules. SOLVENT-FREE EXTRACTION FOR HIGHEST QUALITY SHORTER RUN-TIMES COMBINED WITH USER-FRIENDLY PLATFORM FLEXIBLE CONFIGURATION FOR THE WIDEST RANGE OF LABORATORY NEEDS MARKET-LEADING INNOVATION, SAFETY, AND TECHNOLOGY MILESTONE ETHOS X PERFECTLY FIT FOR To address the limitations of conventional extraction CANNABIS techniques Milestone has developed and patented (European patents EP 1 439 218, EP 1 618 798 and EP 1 629 725) the ETHOS X for Microwave Green EXTRACTION Extraction of Natural Products. The ETHOS X takes advantage of a unique microwave selective heating mechanism. The internal heating of water within the sample distends its cells and leads to rupturing of the glands and oleiferous receptacles. This process frees the oils which are then evaporated with the in-situ water of the plant material. + + - - + + + + + + - - - - - + - - + - - + + - - Effect of the microwave selective heating on the plant cells The most common extraction techniques used in the cannabis field are: hydrocarbon, ethanol and supercritical fluid. The ETHOS X is a perfect complement to any extraction technique as it selectively extracts the terpenes without compromising the subsequent cannabinoid extraction step. Most conventional extraction systems work on dry plant material, causing loss of some of the characteristic terpenes, while the Ethos X works on fresh material providing the most complete and representative terpene profile and maintaining the natural flavor and aroma. The ETHOS X completes the extraction process in only a few minutes without the use of solvent, providing high efficiency, reducing the process costs and ensuring the strain-specific profile of the plant. Milestone Conventional ETHOS X Extraction System Cannabis Plant Terpene Cannabinoids Scheme of the two steps extraction process to selectively extract the terpenes (ETHOS X) and cannabinoids by conventional extraction systems THE EXTRACTION PROCESS SCALABLE PRODUCTIVITY THROUGH FLEXIBLE CONFIGURATION Fresh, frozen or even dry cannabis are placed into the ETHOS X vessel; instrument setup takes only a The Milestone ETHOS X microwave cavity few minutes and the extraction process starts. The has a volume of 70 litres, allowing use of microwave heating allows a quick evaporation of the glass reactors from 2 to 12 litres of volume. target compounds along with the water content of the All the reactors are interchangeable, plant material; the oils and water re-condense into a meeting day-to-day needs with maximum dedicated stainless-steel water-cooled apparatus, and flexibility. are then separated in two phases based on the different densities. The oils (terpenes) are easily separated and collected into a dedicated flask. As the Ethos X doesn’t compromise the THC and CBD, the terpenes-free cannabis can then be processed by any conventional extraction technique to obtain these compounds. EASY EXTRACTION APPROACH TO A FULL Cannabis material Fresh, frozen or dry TERPENE PROFILE Sample amount Up to 3 Kg Typical extraction time Less than 1 hour HIGH-QUALITY TERPENES AT LOW COST The Ethos X microwave technology allows for quick heating of the cannabis material. The extraction process takes only a few minutes and prevents any thermal degradation often noticed during use of conventional extraction methods. The fresh and characteristic taste of strain-specific cannabis is maintained, and high-quality terpenes are assured. In addition to providing this full profile terpene extraction, its simple setup and shorter run-times allow the Ethos X to provide significant return on investment. 2, 5 and 12 liters glass reactors EASY EXTRACTION APPROACH TO A FULL TERPENE PROFILE MILESTONE Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China, HELPING CHEMISTS Japan and Korea. We operate worldwide through a network of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible. ADDITIONAL MILESTONE SOLUTIONS FOR CANNABIS LABS MAC-75 duoPUR/subCLEAN traceCLEAN Large Scale Terpenes Acid Purification Acid Steam Extraction System Cleaning System WWW.MILESTONESRL.COM MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - Italy Tel: +39 035 573857 - Fax: +39 035 575498 www.milestonesrl.com - email: analytical@milestonesrl.com MILESTONE INC. - 25 Controls Drive - Shelton, CT 06484 - USA Tel: (203) 925-4240 - Toll-free: (866) 995-5100 - Fax: (203) 925-4241 www.milestonesci.com - email: mwave@milestonesci.com H E L P I N G C H E M I S T S MILESTONE GENERAL K.K. - KSP, 3-2-1, Sakado - Takatsu-Ku, Kawasaki 213-0012 - Japan - Tel: +81 (0)44 850 3811 - Fax: +81 (0)44 819 3036 UNI EN ISO 9001: 2008 www.milestone-general.com - email: info@milestone-general.com CERTIFIED MLS GmbH - Auenweg 37 D-88299 Leutkirch im Allgau - Germany Tel: +49 (0)7561 9818-0 - Fax: +49 (0)7561 9818-12 T384EN-001 • 2018-06 www.mls-mikrowellen.de - email: mws@mls-mikrowellen.de CA