MILESTONE H E L P I N G C H E M I S T S BEST ELEMENT SUPERIOR AL THROUGHPUT, ANALYSIS QUALITY & ROI BEGINS WITH THE GAME CHANGER IN MICROWAVE SAMPLE PREP GREAT SAMPLE PREPARATION ultraWAVE Single Reaction Chamber Microwave Digestion System ENHANCED EFFICIENCY IN SAMPLE PREPARATION FOR METALS ANALYSIS MARKET-LEADING The ultraWAVE is based on the SRC (Single Reaction INNOVATION Chamber) technology, invented (Patents pending) by Milestone several years ago. The SRC technology achieves extraordinary performance capabilities combining microwave heating with a high-pressure reactor which acts simultaneously as microwave cavity and vessel. The reaction chamber is sealed, pressurized, heated, cooled, vented, and opened via a dedicated touch-screen control terminal. Loading a INCREASED rack of samples into the chamber is the only manual operation in an otherwise fully automated process. The PRODUCTIVITY outer surfaces of the stainless-steel vessel remain at room temperature throughout the entire microwave heating cycle, as the heat generated in the reactor is removed by an integrated cooling system. As a result, the ultraWAVE is dramatically less labor intensive and easier to use compared to conventional microwave systems. ULTIMATE EASE OF USE 26 26b 26a 9a 13 9b 17i 17l 11a 11b 11b 28 13a 15 11a 28a 9c 17b 17c, 17f 17g UNMATCHABLE 16 17a PERFORMANCE 16a 33 31 7 31 7 32 34a 34 22 7a T2 T1 17d 19a 21 17e 19 GREATER RETURN SRC technology schematics ON INVESTMENT THE GAME CHANGER IN MICROWAVE DIGESTION The ultraWAVE fully endorses our vision in microwave sample preparation. It exceeds norms and breaks conventions. It is incredibly easy to use, cost-effective, quick to adopt, and fast to implement. The ultraWAVE has already transformed and enhanced the way analytical chemists prepare their samples for trace metal analysis in hundreds of laboratories all over the world. The ultraWAVE represents the state-of-the-art in microwave sample preparation, overcoming the limitations of the conventional digestion systems. O P T I M I Z E D W O R K F L O W WITH EASY TO USE TECHNOLOGY OPERATING SEQUENCE At the core of the ultraWAVE is a TFM-lined reaction vessel. Samples are weighed into vials and suitable reagents are added without any limitations in type and volume. Vials made from disposable glass, PTFE, and quartz are placed in a rack that is automatically lowered into the reaction chamber. The chamber is sealed and pressurized with inert gas that prevents boiling of the solutions and cross contamination. As microwave energy is applied, all samples are exactly at the same temperature and pressure conditions regardless of the sample weight or type, or acid chemistries employed. At the end of the microwave run, a chiller rapidly lowers the temperature of the solutions. The entire rack is automatically lifted up to facilitate the removal of the solution vials. As a visual aid for the user, the color of the backlit logo indicates the status of the sample preparation process (stand-by, heating, cooling, ready). Sample loading Closing and pressurizing Heating and cooling Pressure release and opening SAFETY Like all Milestone products, the ultraWAVE has been designed with paramount importance to the operator safety. The ultraWAVE is inherently safe: it has been developed for use with any acid or acid combinations Surely, we may conclude that sample and every single stainless-steel reactor is tested at a “ preparation is becoming simple and pressure up to 330 bar. A thick acrylic shield surrounds “ compatible with analytical capability of the working area, correct and safe closure of the reactor modern instrumentation. is ensured by multiple positions sensors located in the system. Temperature and pressure are monitored 20 Microwave-assisted digestion of organic samples: times/sec and the microwave power is automatically how simple can it become? adjusted to control even highly exothermic reactions to J.A. Nobrega et al. - Talanta 98 (2012), 272-276 ensure full control of the sample preparation procedure. DIGESTION VIALS The ultraWAVE rack configurations include a wide amount to be digested. Unlike conventional microwave choice - 4, 5, 8, 15, 19, 22 and 26 positions and also digestion systems, no vessel assembly or disassembly combinations of different vials in the same rack. Vials is required. The use of disposable glass vials eliminates are available in TFM, quartz or disposable glass, and the cleaning step, further enhancing the lab’s workflow. are fitted with loose TFM caps to ensure pressure The fast assembly of the vials, the automatic closing equalization. Numbered rack trays provide the user an (pressure loading) and opening (pressure release) easy visual check of the vial number. The rack can be make the digestion process more efficient and cut the chosen to suit the sample type as well as to the sample handling time, reducing the labor cost up to 50%. ANY SAMPLE ANY TIME THE BENEFITS To date, I haven’t found any sample I “ “ cannot digest in the ultraWAVE. OF SRC TECHNOLOGY Food Lab, The Netherlands. ONE METHOD FOR ALL SAMPLES Any combination of sample types (food, environmental, polymer, cosmetic, pharmaceutical, geological, R R chemical, and petrochemical) can be digested simultaneously; no need to batch samples into identical or similar types. No method development is needed, as B B the same method can be used for nearly any sample. For the first time, blanks and reference standards of any matrix can be digested alongside samples, enabling true in-run digestion quality control. The ultraWAVE dramatically improves the lab workflow, as it allows to run any matrices simultaneously in a single digestion cycle. The schematic shows the ultraWAVE capability of processing in a single run different samples along with standard reference materials and analytical blanks. R=Standard Reference. B=Analytical Blank. 300 240 200 160 100 80 Temperature (C) Pressure (bar) 10 20 30 40 minutes ultraWAVE general digestion method 3 Bovine liver Milk powder ontent (%) 2 1 Residual Carbon C 180 210 240 270 Temp. (C) 200 180 160 140 120 100 80 60 40 20 0 Sequential Conventional ultraWAVE (one by one) (12 samples) (15 samples) 300 240 UNRIVALLED PERFORMANCE FOR SUPERIOR DIGESTION QUALITY 200 160 Operating up to 199 bar pressure and 300°C, the ultraWAVE enables the complete digestion of extremely difficult samples and large amounts of organics, outperforming any other microwave digestion system. Unlike conventional microwave digestion systems, every sample is under direct temperature and pressure control, 100 so there is no need to rely on a reference vessel or indirect control such as infrared temperatur 80 e sensors. The Temperature (C) Pressure (bar) ultraWAVE reaches high temperatures faster, cools faster (10 minutes from 200°C to room temperature), and is capable of higher pressure and temperature than any other system, expanding the digestion efficiency. The ultraWAVE does not suffer any cross contamination between samples. Blanks are significantly lower than 10 20 30 40 minutes with conventional microwaves since less acid is used, and vials have a much less surface in contact with the analytical solution. 3 Bovine liver Milk powder ontent (%) 2 1 Residual Carbon C 180 210 240 270 Temp. (C) 200 Residual carbon content vs digestion temperature. 180 160 140 120 GREEN DIGESTION100 80 For the first time the concepts and significance of green chemistry ar 60 e applied to microwave digestion. The ultraWA 40 VE allows for the complete digestion of 20 organic samples with diluted nitric acid only with clear benefits for the subsequent analytical step and for the 0 envir Sequential Conventional onment as safer and better working conditions ultraWAVE (one by one) (12 samples) (15 samples) are achieved. Less acid also means lower costs associated with its purchase and waste disposal. MILESTONE G R E E N D I G E S T I O N 300 240 200 160 E 100 F F I C I E N T 80 Temperature (C) Pressure (bar) AND COST-EFFECTIVE SAMPLE PREPARATION 10 20 30 40 minutes HIGH PRODUCTIVITY High sample throughput and quick turnaround time are glass vials fully eliminates the cleaning step, further top priorities in most analytical laboratories, along with enhancing the ultraWAVE productivity. Compared with high quality of the analysis and low running costs. The other microwave technologies, either sequential or Milestone ultraWA 3 VE fully matches these requirements. rotor-based, the ultraWAVE simplifies and expedites Compared to any other microwave digestion systems, the sample pr Bovine liver eparation for trace element analysis as the ultraWAVE is significantly easier to use, thus Milk powder its performance allows simultaneous processing of any dramatically improving the laboratory work flow. Any sample. ontent (%) 2 rack, up to 26 samples, can be processed in only 45 minutes from pressing “START” to have the solutions By using the ultraWAVE, our ready for analysis. The ultraWAVE sample throughput is far higher than any other microwave system as “ digestion times do significantly they often involve 1long heating and cooling times. All “ decrease, which gives us a better samples are processed in a single run at the same turnaround time. temperature and pressure, completely eliminating the need to run multiple digestion cycles for different Environmental Contract Lab, New Zealand. Residual Carbon C matrices or acid mixtures. The use of disposable 180 210 240 270 Temp. (C) 200 180 160 140 120 100 80 60 40 20 0 Sequential Conventional ultraWAVE (one by one) (12 samples) (15 samples) Typical sample turnaround time (number of samples in 8 hours) LOW OPERATING COST Although conventional microwave systems have running costs by increasing the consumables lifetime brought acid digestion to a great level of quality, the and by using inexpensive vials suitable for any metals operator often has to go through tedious and time and trace metals determination. The SRC technology consuming procedures to use them. Opening and reduces all the handling time related to the sample closing the vessels, assembly and disassembly of the preparation as the operator only weighs the sample rotors are no longer required in the ultraWAVE. The and adds the suitable reagents, while all the other handling of the system is dramatically reduced, as steps are automatically performed by the system. the digestion vials are made of only two components, simplifying all the sample preparation process. The technology used in all conventional microwaves leads Ultimately, bringing the ultraWAVE to create stressful conditions in the TFM vessels, “ technology in house was the most such as high temperature and pressure, substantially reducing their lifetime. The design of SRC technology, “ sustainable and scalable solution to our work load. with its stainless steel reactor, overcomes the limitations of the rotor-based systems. In addition the Nutraceutical Quality Control Lab, USA. ultraWAVE strongly contributes to the reduction of the The ultraWAVE accommodates inexpensive disposable vials. SMART SOFTWARE DESIGNED AROUND YOU USER INTERFACE The ultraWAVE is controlled via a compact external software. Just recall a previously stored method or terminal with an easy-to-read, bright, full-color, create a new one; press the Start icon and the system touchscreen display. Multiple USB and Ethernet ports will automatically follow the user defined temperature are provided for interfacing the instrument to external profile using a sophisticated PID algorithm. Hundreds devices and to the local laboratory network. The of applications, including all US EPA methods, terminal runs Milestone easyWAVE that is completely are preloaded, eliminating any need for method new user-friendly, icon-driven, and multi-language development. MILESTONE C O N N E C T 30 YEARS OF EXPERIENCE AT YOUR FINGERTIPS The Milestone Connect is an innovative and unique web-based application and is an integral part of the ultraWAVE. The app allows for the remote control of the microwave system through your PC, tablet or smartphone. Furthermore, the Milestone Connect puts our 30 years of applications experience in microwave sample preparation at your fingertips, offering access to a large database of continuously updated scientific papers and application notes. Finally, specific MILESTONE VALIDATION PACKAGE and detailed information on your unit are Compliance with regulations and data traceability provided, such as list of parts, technical requirements are paramount in the modern analytical lab, notes, user manual, video tutorials, etc. such as pharmaceutical, nutraceutical or other regulated A help-on-line section is available to the industries. Milestone’s operating software, easyCONTROL, user 24 hours a day, 7 days a week. is fully compliant with FDA regulation 21 CFR part 11. The Milestone Validation Package gives access to our factory trained engineers and specialists during the qualification process, enabling a fast implementation of the ultraWAVE in full accordance with Good Manufacturing Practice (GMP) guidelines. The comprehensive Milestone Validation Package (MVP) assures the complete qualification of the instrumentation. Different validation packages are available based on your specific needs: IQ (Installation Qualification), OQ (Operational Qualification), PQ (Performance Qualification) and re-qualification. milestone nnect MILESTONE Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China, HELPING CHEMISTS Japan and Korea. We operate worldwide through a network of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible. ADDITIONAL MILESTONE SOLUTIONS FOR ELEMENTAL ANALYSIS ETHOS UP duoPUR/subCLEAN traceCLEAN DMA-80 High Performance Acid Purification Acid Steam Direct Mercury Analyzer Microwave Digestion System Cleaning System System WWW.MILESTONESRL.COM MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - Italy Tel: +39 035 573857 - Fax: +39 035 575498 www.milestonesrl.com - email: analytical@milestonesrl.com MILESTONE INC. - 25 Controls Drive - Shelton, CT 06484 - USA Tel: (203) 925-4240 - Toll-free: (866) 995-5100 - Fax: (203) 925-4241 www.milestonesci.com - email: mwave@milestonesci.com H E L P I N G C H E M I S T S MILESTONE GENERAL K.K. - KSP, 3-2-1, Sakado - Takatsu-Ku, Kawasaki 213-0012 - Japan - Tel: +81 (0)44 850 3811 - Fax: +81 (0)44 819 3036 UNI EN ISO 9001: 2008 www.milestone-general.com - email: info@milestone-general.com CERTIFIED MLS GmbH - Auenweg 37 D-88299 Leutkirch im Allgau - Germany Tel: +49 (0)7561 9818-0 - Fax: +49 (0)7561 9818-12 T328EN-004 • 2018-09 www.mls-mikrowellen.de - email: mws@mls-mikrowellen.de CA