TECHNICAL BULLETIN 926 For The Most Demanding For The Most Demanding High Accuracy Applications The Autopol® The Autopol VI ® Automatic Polarimeter The brand of polarimeter used in more U.S. labs than any other.* *Emmes Survey AUTOPOL® VI The Autopol® VI Automatic Polarimeter was developed for TempTrol™ Electronic Temperature Control System the most demanding analytical laboratories. If you are a high The USP <781> requires optical rotation measurements at 25°C performance lab, the Autopol® VI has the features you must have. ± .5°C (unless another temperature is specified). The European Pharmacopoeia requires optical rotation measurements made Standard Features And Accessories at 20° ± .5°C (unless another temperature is specified). • 0.0003 accuracy for low rotation samples of ±1°Arc Whatever your temperature control needs are, the Autopol® • TempTrol™ – Electronic cooling & heating from 15°-35°C VI’s exclusive TempTrol™ System (Patent No. 2778542) • Six Standard Wavelengths: 365nm, 405nm, 436nm, 546nm, makes your measurement in seconds without a waterbath or 589nm and 633nm any type of water circulation. • 21CFR11 Compliance: Electronic Signature and secure local The TempTrol™ System allows push-button temperature electronic data storage control of your 100mm cell, 200mm cell or Quartz Plate. Set the temperature, push “measure” and walk away. The Autopol® • Domestic 3-year warranty and 20-year support guarantee VI will heat or cool to a predefined temperature and then • Standard Accessories: TempTrol™ NIST Traceable Quartz provide you with the result all in one easy step. Standard, TempTrol™ 100mm Polarimeter Cell, TempTrol™ Temperature Validation Cell, Built-In Sample Measurement Patented TempTrol™ Technology Eliminates the Probe, 3 USB ports Need for a Water Bath. Here is How the TempTrol System Works: TempTrol™ Validation Cell TempTrol™ active surface TempTrol™ Hastelloy™ with Silco Steel™ coating passive surface TempTrol heating and TempTrol cell with mating cooling transfer surface heating & cooling transfer TempTrol™ Hastelloy™ surface manufactured with Measurement Cell acid resistance materials: TempTrol™ NIST Traceable Hastelloy™ and Peek™. Quartz Calibration Standard Versatile Communication Capability Temperature is selected via touch screen. The Autopol® VI’s standard communication package includes: Temperature selection • Ethernet Port for Network Cable Connection of 20°C shown left. • 3 USB ports • 2 RS 232 ports Place the TempTrol Allowing the capability to: cell in your TempTrol equipped Autopol® • Connect directly to Rudolph’s service department for remote sample chamber to testing and diagnostics via Internet connection. measure to within ±0.2°C • Connect to any Windows® based printer via USB or direct to of the USP, EP, JP or BP the server via Windows® Print Library specified temperature • Save measurement data direct to your Network/Server (normally 20°C or 25°C Temperature ±0.5°C) measurement probe Rudolph provides a Water Inlet temperature validation cell with every TempTrol system. The temperature validation cell along with an optional NIST traceable thermometer is designed to validate the temperature control performance of NIST Data connections Thermometer the polarimeter and cell to on back of unit Probe ±0.2°C. Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA • Phone: 973-584-1558 • Fax: 973-584-5440 • E-mail: info@rudolphresearch.com • Internet: www.rudolphresearch.com Full cGMP/GLP Compliance cGMP/GLP Printing Measurement reports can be saved as an Excel or PDF file and edited quickly and easily. You can import logos and print your company’s customized “C of A” directly. Rudolph Research Analytical Tuesday. January 27, 2009 This sample was measured on an Autopol VI serial number 80179, manufactured by Rudolph Research Analytical,Hackettstown, NJ. Set Temperature : 20.0 Temp Corr : OFF n Average Std.Dev. Maximum Minimum 5 34.467 0.0000 34.467 34.467 S.No Time Result Scale OR °Arc WLG Lg.mm Temp. Comment 1 4:32:05 PM 34.467 OR 34.467 589 100.00 20.0 2 4:32:08 PM 34.467 OR 34.467 589 100.00 20.0 3 4:32:10 PM 34.467 OR 34.467 589 100.00 20.0 4 4:32:13 PM 34.467 OR 34.467 589 100.00 20.0 5 4:32:16 PM 34.467 OR 34.467 589 100.00 20.0 Validation and Calibration Rudolph Research Analytical knows that you must be able to validate your instrument’s operating performance Print your customized Certificate regularly. Therefore, the Autopol® VI comes standard with the accessories, validation tools and automatic calibration of Analysis including your functions necessary to ensure that the temperature control, company logo directly from the temperature measurement and optical measurement processes Autopol VI® touch screen are working accurately and reproducibly. All functions are accessed simply and conveniently through the Autopol® VI liquid sealed touchscreen. Rudolph Research Analytical Tuesday, January 27, 2009 This sample was measured on an Autopol VI, serial number 80179, manufactured by Rudolph Research Analytical,Hackettstown, NJ. Just listen Set Temperature : 20.0 Temp Corr : OFF to our customers n Average Std.Dev. Maximum Minimum 5 34.467 0.0000 34.467 34.467 S.No Time Result Scale OR °Arc WLG Lg.mm Temp. Comment “We have the AUTOPOL V from Rudolph Research 1 4:32:05 PM 34.467 OR 34.467 589 100.00 20.0 2 4:32:08 PM 34.467 OR 34.467 589 100.00 20.0 3 4:32:10 PM 34.467 OR 34.467 589 100.00 20.0 Analytical (RRA)... I have used numerous polarimeters 4 4:32:13 PM 34.467 OR 34.467 589 100.00 20.0 5 4:32:16 PM 34.467 OR 34.467 589 100.00 20.0 and this is by far the best. We have had it for 1-1/2 years and have had zero problems, the original lamp is still in the instrument. I recommend it over other instruments. RRA installed, trained and performed the IQOQ... It is one piece of equipment that you never worry about.” Capable of making multiple measurements on a single sample and Alan Davis – Rockwell Medical Technologies reporting complete statistical data and all measurement results Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA • Phone: 973-584-1558 • Fax: 973-584-5440 • E-mail: info@rudolphresearch.com • Internet: www.rudolphresearch.com Rudolph’s Most Advanced Polarimeter Offering 0.0003 Accuracy & Interface Flexibility The Autopol VI comes standard with Hastelloy™ acid resistance Unmatched Accuracy Intuitive Windows® Based Interface For Racemic Solutions and very low concentration samples, • 2 gigabytes of internal memory allow almost unlimited the Autopol® VI provides unmatched 4th decimal optical capacity for saving measurement data. The Autopol® VI is rotation accuracy of ±0.0003°Arc over ±1°Arc. Instrument network ready and data may also be saved directly to your performance for readings between -1 and 1° Arc is: Resolution server or to any directory desired. ±0.0001, Reproducibility ±0.0002, and Accuracy ±0.0003. • Internet access is possible directly from the Autopol® VI’s touch screen. This feature allows real time contact with Rudolph Research Analytical’s Service and Technical Support Team who can access your instrument remotely to assist in Window navigation, method setup and trouble shooting. • Windows based navigation architecture is so intuitive that most operators will never read the manual. But should you wish to reference the manual, it is stored right on the Autopol® VI’s internal memory. • Three USB ports allow quick and easy connection to a mouse, keyboard, printer, bar code scanner, or memory stick. One USB port is located on the front of the unit (shown below) and two USB ports are located on the back of the unit (shown left). Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA • Phone: 973-584-1558 • Fax: 973-584-5440 • E-mail: info@rudolphresearch.com • Internet: www.rudolphresearch.com Flexible Method Management Install your own measurement methods for immediate selection of the correct method to match your most common tests. Setting up your custom method is as simple as filling out a few screens like the one shown to the right. Full 21CFR Part 11 Instrument Level Compliance The Autopol® VI’s 21CFR Part 11 software module is easily enabled through the user friendly touch screen. This module gives you full compliance with: • Electronic signature • Access levels • Internal write protected storage • Unique passwords Acid Resistance • Write protected documents sent directly to server The Autopol® VI comes standard with Rudolph’s Hastelloy™ upgrade option. • Audit trail This option includes a Hastelloy cell and Silco Steel™ cell chamber for increased resistance to acids like 6 Molar HCl. Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA • Phone: 973-584-1558 • Fax: 973-584-5440 • E-mail: info@rudolphresearch.com • Internet: www.rudolphresearch.com Rudolph Research Analytical – still protecting your investment after 30 years. Today our Service Technicians have access to state of the art diagnostic tools and have a depth of knowledge that often lets them solve problems right over the phone. Our customers really appreciate the same day phone call by a real technical service person who wants to solve their problem. Our customers also know that they can expect this support for many years to come as Rudolph is still repairing instruments which were built in the 70’s. Contact us! A customer service representative is waiting to serve you! Phone: 973-584-1558 E-mail: service@rudolphresearch.com Fax: 973-584-5440 Specifications of the AUTOPOL® VI Measuring Mode: Optical Rotation, Specific Rotation, TempTrol™ Range: Automatic Electronic Heating & Concentration & User-defined Scales Cooling 15°-35°C Measuring Scale: Degrees Arc, % Concentration TempTrol™ Accuracy: ±0.2°C Measuring Range: ±89° Arc Optical Rotation, Temp. Probe Range: 10°- 40°C ±999.99° Arc Specific Rotation and Temp. Probe Accuracy: ±0.1°C 0-99.9% Concentration Acid Resistance: Hastelloy™ measurement cell and Performance between -1° Arc and +1° Arc Silco Steel™ sample chamber Resolution: 0.0001° Arc Optical Rotation Measurement Time: 4°/sec. slew rate and 5 sec. nominal 0.0001% Concentration settling time 0.0001° Specific Rotation Light Source: Tungsten-halogen 6V, 20W, Reproducibility: 0.0002° Arc Optical Rotation avg. 2,000 hour life Accuracy: 0.0003° Arc Optical Rotation Sample Chamber: Accepts sample tubes up to 200mm Wavelengths: 589 nm Display: 10.4 inch diagonal, 800-600 pixels, color, Flat Panel Monitor with Resistant Touch Screen Interface, Performance outside of ±1° Arc 200 nits brightness, gasketted for spill protection Resolution: 0.001° Arc Optical Rotation 0.001% Concentration Communication Touch Screen User Interface 0.001° Specific Rotation Interface: 3 – USB Ports 2 – RS232 Ports Reproducibility: 0.002° Arc Optical Rotation Ethernet Port for Network Accuracy: 0.002ůp to 1°, 0.2% from 1° to 5°, Connection 0.01° above 5° Keyboard, Bar Code Scanner, Wavelengths: 365nm, 405nm, 436nm, 546nm, Mouse, Network Capabilities 589nm, 633nm Internal Memory: 2 GB Non-removable Compact Flash Shipping 36 in. (L) x 19 in. (W) x 18 in. (H) Prism: Glan Thompson calcite quartz Dimensions: 91.44 cm (L) x 48.26 cm (W) x 45.72 Optical Wavelengths: cm (H) 365nm, 405nm, 436nm, 546nm, 589nm, 633nm (other wavelengths Shipping Weight: 105 lbs. (31.75 kg) available) Power Supply: 85 to 260 VAC; 48 to 62 Hz Wavelength Selection: Automatic by push-button Power Consumption: 150 – 200 Watts Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA • Phone: 973-584-1558 • Fax: 973-584-5440 • E-mail: info@rudolphresearch.com • Internet: www.rudolphresearch.com