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=LUFRQLDEDOO PP J J $PRXQWRI]LUFRQLDEDOOV &ROOHFWLRQUDWHRI]LUFRQLDEDOOV 3DUWLFOHVL]HGLVWULEXWLRQ $IWHU 3DUWLFOHVL]HGLVWULEXWLRQ ' ' ' ' ' ' %HIRUH %HIRUH $IWHU $IWHU 3DUWLFOH6L]H'LVWULEXWLRQ 3DUWLFOH6L]H'LVWULEXWLRQ OXPH OXPH 9R 9R 13 %DOOPLOO 13 %DOOPLOO %HIRUH $IWHU 3DUWLFOH6L]H ѥm %HIRUH $IWHU 3DUWLFOH6L]H ѥm 5 6 Pulv Oper eriz Nano Pulverizer NP-100 Nano Pulverizer NP-100 a ed / Deagglomer tion Pulverized / Deagglomerated samples Operation Medical and pharmaceutical materials Precool before pulverization ated Samples / Nano P Phenytoin (Low solubility compounds) Indomethacin (Low solubility compounds) Cooling time in the chamber Parameter 2000 rpm 2 min Parameter 2000 rpm 3 min Compound Phenytoin Compound Indomethacin Dummy weight Weight 100 mg Weight 100 mg Concentration 10 mg/ml Concentration 10 mg/ml Before Zirconia ball Before Zirconia ball Grinding tool Grinding tool article F 0.1 mm 0.1 mm Particle size distribution Particle size distribution D10 D50 D90 D10 D50 D90 orma Before 5.774 10.58 18.639 Before 3.89 12.894 37.092 Approx. time to cool to -20 °C After (SEM image x30 K) After 0.069 0.125 0.231 After (SEM image x30 K) After 0.069 0.126 0.237 Temperature indication : ≈30 minutes tion of Lo Cup holder Counter balance adjustment dial (Temperature of the chamber interior atmosphere) Particle Size Distribution Particle Size Distribution Cup holder : ≈60 minutes ) ) w Melting P lume (% lume (% Vo Vo Basic operation (Pulverization) Before After Particle Size m Before After Particle Size m oint Compounds Nano Pulverizer NP-100 Nano Particle Formation of Low Melting Point Compounds Crystallinity evaluation method after pulverization Particle size distribution: Crystallinity: Crystallinity: Thermogravimetric and Laser diffraction Powder X-ray diffraction differential thermal analyzer Representative diameters: D50 and D90 ( m) PXRD TG / DTA Compound 100 mg Medium Basic operation (Separation of media) 0.1 mm, 2.5 g 0.3 MC solution 0.5 ml → 9.5 ml Temperature before and after pulverization 0 9.3 Compound 100 mg Medium 0.1 mm, 2.5 g 0.3 MC solution 0.5 ml → 9.5 ml Temperature before and after pulverization 0 15.5 Compound 100 mg Medium 0.1 mm, 2.5 g 0.3 MC solution 0.5 ml (SDS added)→ 9.5 ml Temperature before and after pulverization 6.3 20.3 Nano-pulverization of poorly water soluble compounds with low melting points by a rotation/revolution pulverizer K.Yuminoki, M.Takeda, K.Kitamura, S.Numata, K.Kimura, T.Takatsuka, N.Hashimoto Journal of pharmaceutical sciences 103:3772-3781, 2014 7 8 User Latest Optional T Nano Pulverizer NP-100 Nano Pulverizer NP-100 s’ V oice / Column Users’ Voice / Column Latest Optional Tools / Our Support System ools / Our Support System Users’ voice Latest optional tools Simultaneous process of two samples in 10 ml zirconia containers NP-100 nano pulverizer is essential for the study of next-generation batteries Zirconia containers to pulverize minimum of 10 ml material The two data overlaps each other. 10 ml zirconia container lid 10 ml zirconia containers x2 µ Trigger to adopt NP-100 and * The particle sizes of the two samples are uniform. the area of the use 10 ml zirconia container adapter Shohji Tsushima Particle size difference when pulverizing 100 mg or less material in 10 ml zirconia container (red) and 80 ml standard container (green) Professor, Doctor (Engineering) Department of Mechanical Engineering, Graduate School of Engineering, Osaka University Research overview µ 10 ml zirconia container set * Compared with the standard container, the 10 ml zirconia container tends to have Maximum liquid feed amount: 10 ml more uniform pulverized particle sizes. The reason is that the small diameter of the 10 ml container increases frequencies of collisions between the balls and the Recommended amount of pulverization: 10 to 100 mg material to contribute to pulverization efficiency. Recommended recipe available (pulverizing phenytoin) Column Increased frequency of collision between balls and Simultaneous process of two samples to increase Comparison with the material to improve pulverization efficiency efficiency NP-100 joint developer’s untold story of the development standard container Tendency of more uniform particle sizes after Less heat generation during pulverization (80 ml container) pulverizing 100 mg or less Reduced material loss due to adhesion of the container Major advantages to pulverize the drug into nano particles Our Support System Two secure support systems Naofumi Hashimoto After-sales support Please contact THINKY CORPORATION Professor, Doctor (Pharmacy) Department of Pharmaceutical Sciences, Email: info@thinkymixer.net Faculty of Pharmaceutical Sciences, Setsunan University Application engineering THINKY Development of NP-100 http://www.thinkymixer.net/ THINKY continues to assist customers with our full support system. 9 10