MILESTONE H E L P I N G C H E M I S T S BEST ELEMENTAL ANAL THE RIGHT COMBINA YSIS TION BEGINS WITH OF PERFORMANCE AND PRODUCTIVITY IN ELEMENTAL ANALYSIS GREAT SAMPLE PREPARATION ultraCLAVE Fully Automated Single Reaction Chamber Microwave Digestion System THE TECHNOLOGY THAT REVOLUTIONIZED SAMPLE PREPARATION MARKET-LEADING Thousands of laboratories worldwide perform heavy INNOVATION metals analysis on a wide variety of matrices daily with sample preparation often bottlenecking productivity and efficiency. The ultraCLAVE was invented and introduced by Milestone in the mid 90’s, and is based on the revolutionary concept of Single Reaction Chamber technology (SRC), more recently applied by Milestone to the ultraWAVE. SRC technology breaks the standard paradigms in microwave digestion, moving from rotor-FULLY based technology to a high-pressure stainless-steel AUTOMATED reactor. The ultraCLAVE is capable of running as many as 77 samples simultaneously at high temperature up to 300 °C and pressure up to 200 bar, thus enhancing lab efficiency. ENHANCED PERFORMANCE UNSURPASSED THROUGHPUT Patents: GREAT RETURN US 5,382,414-5,725,835 Germany 4105094-4114525 ON INVESTMENT Europe EP0728038-W09513133 THE STATE-OF-THE-ART IN MICROWAVE SAMPLE PREPARATION The ultraCLAVE's utilization of SRC technology allows for the processing of mixed matrices in the same run with different chemistries and to use vials/racks instead of vessels/rotors, which essentially removes the handling step in sample preparation. The ultraCLAVE completely changes the rules in microwave sample preparation and sets new standards in digestion, enhancing the overall efficiency in elemental analysis. A STEP FORWARD IN SAMPLE PREPARATION AUTOMATION THE OPERATING SEQUENCE WITH SRC TECHNOLOGY Sample preparation is the most labor-intensive step in elemental analysis, as it requires assembling, closing, opening and disassembling of the vessels. These operations involve a lot of handling, which is directly affected by the number of vessels used. The ultraCLAVE with SRC technology, uses vials and racks instead of rotors and vessels, completely removing laborious handling. SRC technology is based on a stainless-steel reactor with a volume in excess of 4 L, which act as both a microwave cavity and digestion vessel. A 3.5 L PTFE vessel with a base load is introduced into the stainless-steel reactor. The operator places the samples and acids into vials with loose-fitting caps, places the rack in the ultraCLAVE Step 1 and the digestion process begins (Step 1). By pressing “START” on the dedicated large screen terminal, the system automatically closes the stainless-steel vessel and clamps, loads the nitrogen pressure and runs the pre-selected microwave program (Step 2). After completion the vials are cooled using a powerful external chiller, pressure is safely released, and the main reactor opens, delivering the digested solutions ready for dilution and analysis (Step 3). COMPLETE DIGESTION CONTROL The ultraCLAVE microwave program is fully controlled by our Step 2 easyCONTROL software. Simply press start and the temperature program is precisely followed, simultaneously controlling all digestion parameters. The same digestion conditions are ensured in all vials through a dedicated sensor directly immersed in the base load. As the samples sit in the base load, any sample type and amount with different acid mixtures and volumes can be used simultaneously, ensuring the same temperature and pressure in all vials and enhancing the lab workflow. The wide temperature and pressure working range allows for the complete digestion of highly reactive matrices, large masses of organic samples and hard-to-digest samples, resulting in a valuable tool for elemental analysis. Step 3 DIGESTION VIALS SRC technology completely changes the rules of sample preparation. Instead of using a traditional digestion rotor, a rack and vials with loose-fitting caps are used, which greatly simplifies daily operation and reduces running costs. The ultraCLAVE racks are available in several configurations to accommodate varying sample throughput needs as well as large sample masses. Several racks are available and the selection of vials includes high-purity PTFE, quartz and disposable glass. The use of disposable glass vials eliminates the tedious and time-consuming cleaning step, improving lab workflow. Rack handling is as simple as hanging it in the system. Moreover, SRC technology allows for the use of a single method regardless of the sample type and amount, making it possible to digest different matrices together in the same run (see picture below of the ultraCLAVE rack loaded with different matrices). Example of racks available Vials materials with loosing fit caps Typical sample amount Typical acid volume 6 positions PTFE and Quartz Up to 5 g 20-25 mL 15 positions PTFE and Quartz 2 g 10-15 mL 25 positions PTFE and Quartz 1 g 5-10 mL 40 positions PTFE, Quartz and disposable glass 0.5 g 5 mL 62 positions PTFE, Quartz and disposable glass 0.5 g 3-4 mL 77 positions PTFE, Quartz and disposable glass 0.2 g 3-4 mL ultraCLAVE rack with Ø16 mm vials available with 40 and 62 positions GAIN EFFICIENCY WITHOUT COMPROMISING PERFORMANCE PERFORMANCE The combination of stainless-steel reactor with microwave technology results in a digestion system with superb performance and abilities. The temperature range up to 300 °C allows for the digestion of virtually any sample, while the maximum pressure of up to 200 bar allows for digesting very large sample amounts. Highly reactive samples such as large amounts of food, pharmaceuticals, polymers and petrochemicals can be completely digested. Furthermore, the platform's flexibility found a natural fit in other analytical testing labs such as environmental, clinical and biological. The ultraCLAVE allows for the simultaneous digestion of completely different matrices with different chemistries, as the set conditions in the stainless-steel cavity are applied to all vials, ensuring complete digestion of all samples in the reaction chamber. 300 240 200 160 Pressure (bar) Temperature (°C) 100 80 0 10 20 30 40 50 minutes Typical ultraCLAVE digestion cycle with the 40 position rack. 0.5 g of organic samples such as infant formula, butter an API and fish oil with 5 mL of HNO 3 SIMULTANEOUS DIGESTION OF ANY SAMPLE Agriculture Beverage Ceramics Chemicals Clinical Cosmetics Environmental Food & Feed Geochemistry Petrochemical Officials Pharmaceutical Pigments Polymers GREATER PRODUCTIVITY & ROI SMART SOFTWARE SRC technology offers high throughput without compromising productivity. The ultraCLAVE greatly TO SAVE reduces handling and operator time, eliminates the need to batch the samples and to clean of vials, resulting in a more productive approach to digestion across multiple YOUR TIME industries. Most samples will be digested using a single program, eliminating method development and simplifying the digestion procedure. The ultraCLAVE is an efficient The ultraCLAVE is controlled via a large tool for mixed or similar samples. Lab throughput is greatly external terminal with an easy to read, bright, enhanced, with a microwave digestion cycle taking about full-color touchscreen display. Multiple 60 minutes for 62 or 77 samples. Lab efficiency is improved USB and ethernet ports are provided for by removing the need to batch samples, speeding up the interfacing the instrument to external devices digestion cycle and using inexpensive consumables. The and to the local laboratory network. The ultraCLAVE offers superior productivity, ease of use and terminal runs Milestone's easyCONTROL performance far surpassing any conventional digestion software, which is user-friendly, icon-system. driven, and multi-language. Simply recall a previously stored method or create a new one. Press the "START" icon and the system Efficiency comparison will automatically follow the user defined temperature profile using a sophisticated PID algorithm. The easyCONTROL HIGH software controls and monitors all digestion parameters, providing the right amount of power to follow the pre-set temperature and pressure profile. Additional safety parameters MEDIUM are continuously monitored, such the reactor temperature and the pressure limit. Several applications, including all US EPA methods LOW are pre-loaded, eliminating any need for method development. Operator time per run Productivity per day Running cost ultraCLAVE (SRC technology) Rotor-based technology The above graph compares the efficiency ratio between a rotor-based system (f.e. 40 positions) and the ultraCLAVE (with 40 positions) with SRC technology, considering operator time, productivity and running costs MILESTONE Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China, HELPING CHEMISTS Japan and Korea. We operate worldwide through a network of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible. ADDITIONAL MILESTONE SOLUTIONS FOR ELEMENTAL ANALYSIS ETHOS UP ultraWAVE DMA-80 High Performance The Game Changer in Microwave Direct Mercury Analyzer Microwave Digestion System Digestion traceCLEAN duoPUR/subCLEAN Acid Steam Cleaning System Acid Purification System WWW.MILESTONESRL.COM MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - Italy Tel: +39 035 573857 - Fax: +39 035 575498 www.milestonesrl.com - email: analytical@milestonesrl.com MILESTONE INC. - 25 Controls Drive - Shelton, CT 06484 - USA Tel: (203) 925-4240 - Toll-free: (866) 995-5100 - Fax: (203) 925-4241 www.milestonesci.com - email: mwave@milestonesci.com H E L P I N G C H E M I S T S MILESTONE GENERAL K.K. - KSP, 3-2-1, Sakado - Takatsu-Ku, Kawasaki 213-0012 - Japan - Tel: +81 (0)44 850 3811 - Fax: +81 (0)44 819 3036 UNI EN ISO 9001: 2008 www.milestone-general.com - email: info@milestone-general.com CERTIFIED MLS GmbH - Auenweg 37 D-88299 Leutkirch im Allgau - Germany Tel: +49 (0)7561 9818-0 - Fax: +49 (0)7561 9818-12 T305EN-004 • 2020-02 www.mls-mikrowellen.de - email: mws@mls-mikrowellen.de CA