MILESTONE H E L P I N G C H E M I S T S QUALITY ANALYSIS BEST ELEMENTAL ANALYSIS BEGINS WITH STARTS WITH GREAT SAMPLE PREP GREAT SAMPLE PREPARATION ETHOS UP High Performance Microwave Digestion System T H E F I R S T S T E P T O C O N F I D E N T ULTIMATE EASE OF USE R E S U LT S AND CONTROL It is a common misconception that all laboratory microwave systems are alike; at Milestone we know this is not true. Sample preparation is one of the most impactful steps in trace metals determination. The quality of analytical data obtained by ICP/ICP-MS is directly reliant on digestion quality. Today, microwave technology in sample preparation has been established in a variety of industries: Environmental, UNRIVALED PERFORMANCE Food, Pharmaceutical, Agriculture, Consumer Product AND THROUGHPUT Testing, Specialty Chemicals, Geological, Mining, and many others. Milestone’s sample preparation solutions maximize the AA/ ICP/ ICP-MS/ performance, and a lab's overall analytical capability. EXPERTISE FOCUS ON WHAT MATTERS: YOUR APPLICATION Choosing the right system and configuration is a key AND KNOW-HOW step in maximizing investment and expanding your lab’s capabilities. Some of the most crucial parameters that should be considered when choosing a microwave digestion system include the following: SAMPLE TYPE SUPERIOR SAFETY LAB THROUGHPUT AND RELIABILITY SIMPLICITY AND EASE OF USE RELIABILITY FLEXIBILITY FLEXIBILITY SAFETY AND RELIABILITY IN SAMPLE PREPARATION The ETHOS UP fully embodies Milestone’s philosophy towards, and knowledge of, microwave sample preparation. Specifically designed for closed vessel acid digestion, it offers a perfect integration of microwave hardware, user interface, reaction sensor technology and pressure resistant vessels. The ETHOS UP is the most powerful system in the market, with two magnetrons and a total power of 1900 Watts. Microwave homogeneity is assured through a dedicated microwave diffuser. Safety and reliability are Milestone’s priorities. Both factors are ever present in the foundation of the ETHOS UP’s design. The cavity has a volume in excess of 70L, and is constructed entirely of stainless steel to ensure longevity and structural integrity. Our unique pressure responsive door, also made of stainless steel, ensures superior safety even with the most reactive samples. The safeVIEW high definition digital camera, allows to safely look into the microwave cavity. In a digestion process the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined EASE OF USE with an in-situ temperature sensor to more accurately WITH UNPARALLELED control the digestion cycle. Today, Milestone innovates again by combining all the benefits of in-situ and infrared DIGESTION CONTROL sensors into a single solution: the Milestone easyTEMP, a direct contactless temperature sensor. MILESTONE easyTEMP IN-SITU APPROACH INFRARED APPROACH EASE OF USE DIRECT CONTROL PRECISION AND ACCURACY CONTROL IN ALL VESSELS SAFETY RUN ANY NUMBER OF VESSELS API (Active Pharmaceutical Ingredient) T1: Kw °C T2: 199 °C 1.8 (set: 200 °C) P1: 1.6 200 P2: API (Active Pharmaceutical Ingredient) MW: 0 W 1.4 5 T1: 6 4 3 Kw 1.2 7 °C T2: 199 °C 150 2 1.8 178 (set: 200 °C) 1 1.0 189 P1: 15 10 1.6 14 11 200 P2: 0.8 13 12 MW: 0 W 100 1.4 0.6 5 6 4 3 150 1.2 7 2 0.4 178 50 1 1.0 189 15 0.2 10 14 11 13 12 100 0.8 0.6 5 10 15 20 25 min 50 0.4 T1 T2 P1 P2 MW 0.2 5 10 15 20 25 min M I L E S TO N E www.milestonesrl.com T1 T2 P1 P2 MW H E L P I N G C H E M I S T S M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S API (Active Pharmaceutical Ingredient) US EPA 3051 T1: T1: Kw °C T2: 199 °C °C T2: 179 °C 1.8 (set: 200 °C) (set: 180 °C) P1: 200 P1: 1.6 200 P2: P2: MW: 0 W US EPA 3051 MW: 0 W 1.4 12 13 11 5 14 6 4 150 10 34 33 35 32 3 T1: 15 36 9 31 150 1.2 7 16 37 30 2 T2: 179 °C 8 38 29 178 °C 17 7 1 39 28 1.0 18 18 6 9 (set: 180 °C) 40 27 15 19 41 26 5 10 200 P1: 20 42 25 14 4 43 11 21 44 23 24 3 13 12 P2: 100 22 1 2 100 0.8 MW: 0 W 0.6 12 150 13 11 14 10 34 33 35 32 15 36 9 31 16 37 30 8 50 0.4 50 38 29 17 7 39 28 18 6 40 27 0.2 19 41 26 5 20 42 25 4 43 100 21 44 23 24 3 22 1 2 5 10 15 20 25 min 5 10 15 20 min 50 T1 T2 P1 P2 MW T1 T2 P1 P2 MW 5 10 15 20 min M I L E S TO N E www.milestonesrl.com M I L E S TO N E www.milestonesrl.com T1 H ET2 L P I N P1 G P2 MW H E L P I N G C H E M I S T S C H E M I S T S M I L E S TO N E www.milestonesrl.com easyTEMP temperature control of an exothermic reaction H E L P I N G C H E M I S T S Temperature profile of a soil digestion in accordance during the digestion of an API with HNO and HCl with US EPA 3051 using the MAXI-44 rotor 3 in the SK-15 rotor US EPA 3051 T1: Door locked °C T2: 179 °C °C (set: 180 °C) 1 1 1 200 T2 200 P1: 1 1 1 1 1 S Add R1 R2 150 P2: 100 MW: 0 W 50 12 150 13 11 14 10 34 33 5 10 15 20 35 32 Door locked 15 36 9 31 12 16 37 30 8 13 11 T1: 38 29 17 7 39 °C 28 14 10 34 33 18 T2: 179 °C 1 6 40 1 1 200 27 T2 35 32 19 41 26 5 1 1 15 36 9 (set: 180 °C) 1 1 31 1 S Add R1 R2 20 42 25 4 150 43 100 21 44 23 24 3 22 1 2 P1: 100 16 37 30 8 P2: 50 38 29 MW: 0 W 5 10 15 20 INCREASED EASE OF USE AND PRODUCTIVITY 17 7 50 12 13 11 T1: 39 28 14 10 34 33 35 32 T2: 179 °C 18 6 15 40 27 36 9 31 (set: 180 °C) P1: 19 41 26 5 16 37 30 8 P2: ENHANCED CONTROL IN ALL VESSELS 5 10 15 20 min 42 25 38 29 MW: 0 W 20 4 17 43 7 44 23 24 T1 21 3 39 T2 P1 P2 MW 28 22 1 2 18 6 40 27 FAST, ACCURATE AND TRACEABLE 19 41 26 5 42 25 M I 20 LE 43 21 S T O 44 N E 4 www.milestonesrl.com 23 24 3 H E L P22 I N G www.milestonesrl.com 1 2 SUPERIOR DIGESTION QUALITY M I L E S TO N E C H E M I S T S H E L P I N G C H E M I S T S LOWER RUNNING COSTS M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S This rotor diagram represents the digestion temperature Door locked in all vessels. The green color indicates if the vessel has °C 1 1 1 200 T2 1 1 1 1 1 S Add R1 R2 150 achieved the set conditions 100 50 5 10 15 20 12 13 11 T1: 14 10 34 33 35 32 T2: 179 °C 15 36 9 31 (set: 180 °C) P1: 16 37 30 8 P2: The easyTEMP contactless sensor dir 38 29 MW: 0 W 17 7 ectly controls 39 28 the temperatur 18 e of all samples and solutions, pr 6 40 27 oviding 19 41 26 5 accurate temperatur 20 42 e feedback to ensur 25 4 e complete 43 44 23 24 digestion in all vessels 21 3 22 1 2 with superior safety. This technology combines the fast and accurate reading e a s y T E M P of an in-situ temperature sensor with the flexibility M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S DIRECT CONTACTLESS of an infrared sensor. The ETHOS UP software provides digestion history traceability and temperature TEMPERATURE SENSOR measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be IN ALL VESSELS saved on the ETHOS UP terminal. FLEXIBILTY AND P E R F O R M A N C E Rotors and pressure vessels are crucial components THAT MAKE THE to ensure high digestion quality and safety. Milestone's D I F F E R E N C E rotors are build with high-purity PTFE-TFM, PEEK safety shields and a unique safety release mechanism. SK-15 ROTOR Regardless of the samples you’re trying to digest, the SK-15 High-pressure rotor is always an effective option to simplify your journey from sample to analysis, even with hard-to-digest samples, reactive samples or large sample masses. The SK-15 is a high-pressure and high-temperature rotor with a capacity of up to 15 PTFE-TFM vessels of 100 mL. UNMATCHABLE VERSATILITY LARGE SAMPLE MASS HIGH PERFORMANCE MAXI-44 ROTOR Many laboratories routinely process high number of samples, such as soils, sediments and aqueous samples. The MAXI-44, featuring up to 44 PTFE-TFM vessels of 100 ml, perfectly matches these requirements, providing high productivity, reliability and superior ease of use. The MAXI-44 finds its natural fit in all laboratories requiring to process large samples batches. DIGEST LARGE BATCHES EASY HANDLING HIGH PRODUCTIVITY SUPERIOR POWER VENT-AND-RESEAL TECHNOLOGY AND PERFORMANCE The vent-and-reseal technology ensure high quality digestion and full safety. The safety spring built into FOR HIGH-VOLUME the cover allows for precise venting of the vessel, if that should occur. Once the pressure has been LABORATORIES reduced to a containable level, the cover closes again. Only the excess pressure, mainly generated by CO , NO fumes, is therefore released, allowing 2 X for a complete recovery of even volatile elements. MAXI-24 HP ROTOR The MAXI-24 High Performance (HP) and high throughput rotor was designed with double pressure limits and greater capacity than other high throughput TYPICAL APPLICATIONS rotors. It process increased volumes of sample and a wide variety of matrices within a single rotor-based platform. The MAXI-24 HP, along with the built-in easyTEMP, contactless temperature control in all Agriculture Beverage Cannabis Ceramics vessels, automatically controls the temperature even in case of exothermic reactions. Quick-assembly vessels are closed with a simple hand-tightening, improving your daily productivity. Chemicals Geochemistry Metals Petrochemical HIGHER THROUGHPUT Clinical Cosmetics Environmental Food & Feed GREATER CAPACITY HIGHER PRESSURES EASY HANDLING Officials Pharmaceutical Pigments Polymers MORE PROFITABLE RUNS SMART SOFTWARE TO SAVE YOUR TIME The ETHOS UP comes with a dedicated touch new one yourself using our intuitive software. Once you screen terminal with easyCONTROL software which press ‘START’ the system will automatically follow the incorporates our expertise and knowledge in microwave user defined temperature profile using a sophisticated sample preparation. The ETHOS UP user-interface PID algorithm. The preloaded applications, including provides full control of all digestion parameters, all US EPA methods, virtually eliminate any need complete documentation and improves the overall for method development. Each preloaded method procedure. The terminal is equipped with multiple includes a temperature profile, sample size and choice USB and Ethernet ports for interfacing the instrument of reagents. To further simplify the workflow in the to external devices and to the laboratory network.The lab the ETHOS UP is equipped with a backlit logo ETHOS UP controller is user-friendly, icon-driven, multi-that indicates the digestion progress, showing to the language and 21 CFR Part 11 compliant. To find the operator the actual status of the process, such as method which best suits your application, simply select heating, cooling, sample ready and error messages. one of the hundreds of preloaded methods or create a Food & Feed Baby Food MAXI-44 Barley MAXI-44 Beech Leaves MAXI-44 Bovine Liver MAXI-44 Bovine Milk MAXI-44 Butter MAXI-44 Calcium Alginate MAXI-44 Casein MAXI-44 Chcolate MAXI-44 Cocoa Powder MAXI-44 Cofee MAXI-44 Corn Starch MAXI-44 Dried Fish MAXI-44 Dried Meat MAXI-44 Dry Infant Formula MAXI-44 Deed for Fish MAXI-44 Fish in Oil MAXI-44 Fresh Meat MAXI-44 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S °C bar 100 200 T1 175 80 150 125 60 100 75 40 50 25 20 2 4 6 7 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 Nr t MW T1 [ W ] [ °C ] VAC Stirrer 1 00:15:00 1800 200 2 00:15:00 1800 200 3 00:00:00 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S Door locked °C 200 T1 150 T1: 21 °C 100 50 10 20 30 40 (set: 21 °C) 5 6 4 3 7 2 178 T2: 1 21 °C 189 15 10 14 11 13 12 P1: 1.0 bar P2: 0 % MW: 0 W t: 00:50:00 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S Door locked °C 1 1 1 200 T1 1 1 1 1 1 S Add R1 R2 150 100 50 10 20 30 40 T1: 21 °C 5 (set: 21 °C) 6 4 T2: 21 °C 3 P1: 1.0 bar 7 P2: 0 % MW: 0 W 2 t: 00:50:00 178 1 IR 189 15 10 14 11 13 12 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S - Created from "Administrator" "test sk15-sludgeCRM.dpr" 27.03.2014 09:15:20 1 + °C bar kW 100 1.8 180 T1 90 1.6 160 80 1.4 140 70 1.2 Number of 120 60 1.0 pages 100 50 0.8 80 40 1 60 0.6 30 40 0.4 T2 20 P1 20 10 0.2 2 4 6 8 10 12 14 16 18 20 22 24 26 28 Parameter "USEPA 3051 Soil, sediments, sludges and oils" MW program "USEPA 3051 Soil, sediments, sludges and oils" Exhaust : 15 min ñññ Nr t T1 T2 P E Vent. P2-Check : not present 1 00:10:00 175°C 1000W ñññ Stirrer : not present 2 00:05:00 175°C 1000W ñññ Twist : Off Rotor control : On Start-Parameter : Current values Control for : T1 System : Ethos 1 Rotor : SK Type of vessels : Number of vessels : 0 Cooling system : Operating mode : MW cont. Remarks 0,5g of sample 10ml of HNO3 or 9ml of HNO3 and 3ml of HCl M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S Food & Feed Terminal Settings Service Baby Food MAXI-44 Panel Users Update LAN Trail Barley MAXI-44 All System Access Errors Application Beech Leaves MAXI-44 Bovine Liver MAXI-44 Time Changes 28.02.17 14:21:01 Seg6=00:02:00/1000W7210°C/0°C/30.0bar/0/0/3 Bovine Milk MAXI-44 28.02.17 14:21:11 Start: P Test Butter MAXI-44 28.02.17 15:10:34 P test_20170228_14211.dpr: saved to: A/Data/P Test_ Calcium Alginate MAXI-44 28.02.17 15:26:19 Start: Milk powder_tests elastomer Casein MAXI-44 28.02.17 16:26:24 Program finished Chcolate MAXI-44 28.02.17 16:44:04 Milk powder_test elastomer_20170228_152619.dpr: Cocoa Powder MAXI-44 01.03.17 08:52:22 Login Admin (Administrator) Cofee MAXI-44 01.03.17 08:52:29 test for thermo_mat.fat: File read error. Corn Starch MAXI-44 01.03.17 08:53:32 Start: Milk powder_test elastomer Dried Fish MAXI-44 01.03.17 09:43:47 Milk powder_test elastomer_20170301_085332.dpr: Dried Meat MAXI-44 01.03.17 09:58:24 Login Admin(Administrator) Dry Infant Formula MAXI-44 01.03.17 09:59:34 New Method from database: P Test Digestion Agricol Deed for Fish MAXI-44 01.03.17 10:01:21 Login (Service) Fish in Oil MAXI-44 Fresh Meat MAXI-44 Filter Usage M I L E S TO N E www.milestonesrl.com M I L E S TO N E www.milestonesrl.com H E L P I N G H E L P I N G C H E M I S T S C H E M I S T S List of food & feed methods, part of the expansive Audit trail tacking in full compliance library containing over 300 built-in methods with 21 CFR part 11 °C bar 100 200 T1 175 80 150 125 60 100 Included with the ETHOS UP is a unique web-based 75 40 50 25 milestone 20 application: Milestone Connect. This app allows you to 2 4 6 7 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 become a part of the Milestone community and gain Nr 2 3 nnect t MW T1 [ W ] [ °C ] VAC Stirrer 1 00:15:00 1800 200 exclusive access to a robust library of information: 00:15:00 1800 200 00:00:00 lists of parts, technical notes, user manuals, video tutorials, continuously updated application notes and all relevant scientific articles. Milestone Connect also M I L E S TO N E www.milestonesrl.com H E L P I N G extends instrument control to your smartphone, tablet C H E M I S T S or PC, allowing remote monitoring of the system. With Milestone Connect you have instant support 24/7. Door locked °C 200 T1 150 T1: 21 °C 100 50 10 20 30 40 (set: 21 °C) 5 6 4 3 7 2 178 T2: 1 21 °C 189 15 10 14 11 13 12 P1: 1.0 bar P2: 0 % MW: 0 W t: 00:50:00 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S MILESTONE C O N N E C T 30 YEARS OF EXPERIENCE Door locked °C 1 1 1 200 T1 1 1 1 1 1 S Add R1 R2 150 AT YOUR FINGERTIPS 100 50 10 20 30 40 T1: 21 °C 5 (set: 21 °C) 6 4 T2: 21 °C 3 P1: 1.0 bar 7 P2: 0 % MW: 0 W 2 t: 00:50:00 178 1 IR 189 15 10 14 11 13 12 M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S - Created from "Administrator" "test sk15-sludgeCRM.dpr" 27.03.2014 09:15:20 1 + °C bar kW 100 1.8 180 T1 90 1.6 160 80 1.4 140 70 1.2 Number of 120 60 1.0 pages 100 50 0.8 80 40 1 60 0.6 30 40 0.4 T2 20 P1 20 10 0.2 2 4 6 8 10 12 14 16 18 20 22 24 26 28 Parameter "USEPA 3051 Soil, sediments, sludges and oils" MW program "USEPA 3051 Soil, sediments, sludges and oils" Exhaust : 15 min ñññ Nr t T1 T2 P E Vent. P2-Check : not present 1 00:10:00 175°C 1000W ñññ Stirrer : not present 2 00:05:00 175°C 1000W ñññ Twist : Off Rotor control : On Start-Parameter : Current values Control for : T1 System : Ethos 1 Rotor : SK Type of vessels : Number of vessels : 0 Cooling system : Operating mode : MW cont. Remarks 0,5g of sample 10ml of HNO3 or 9ml of HNO3 and 3ml of HCl M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S Terminal Settings Service Panel Users Update LAN Trail All System Access Errors Application Time Changes 28.02.17 14:21:01 Seg6=00:02:00/1000W7210°C/0°C/30.0bar/0/0/3 28.02.17 14:21:11 Start: P Test 28.02.17 15:10:34 P test_20170228_14211.dpr: saved to: A/Data/P Test_ 28.02.17 15:26:19 Start: Milk powder_tests elastomer 28.02.17 16:26:24 Program finished 28.02.17 16:44:04 Milk powder_test elastomer_20170228_152619.dpr: 01.03.17 08:52:22 Login Admin (Administrator) 01.03.17 08:52:29 test for thermo_mat.fat: File read error. 01.03.17 08:53:32 Start: Milk powder_test elastomer 01.03.17 09:43:47 Milk powder_test elastomer_20170301_085332.dpr: 01.03.17 09:58:24 Login Admin(Administrator) 01.03.17 09:59:34 New Method from database: P Test Digestion Agricol 01.03.17 10:01:21 Login (Service) Filter Usage M I L E S TO N E www.milestonesrl.com H E L P I N G C H E M I S T S The ETHOS UP embraces Milestone’s philosophy of a “microwave labstation”. The ETHOS UP platform MILESTONE ETHOS UP is capable of several applications beyond microwave digestion. Extraction of pollutants from environmental MUCH MORE samples can be done in just few minutes, consuming less solvent than other technologies, thereby THAN A DIGESTION SYSTEM improving productivity while decreasing costs, all in full accordance with the US EPA 3546. Additional fastEX-24 SK-10/12 Extraction rotor for environmental applications High-pressure digestion rotor Soxhlet fastEX-24 SR-12 Extraction rotor for total fat determination 100% in food samples PCBs PAHs TPH Dioxins Organic BNAs semivolatiles Milestone fastEX-24 recovery study and comparison vs Soxhlet for various organic compounds. accessories are available to further expand the ETHOS MEETING REGULATIONS: UP capabilities: additional digestion rotors, inserts and micro-inserts to reduce blanks in the digestion M I L E S T O N E ' S processes, a dedicated configuration for total fat determination in food samples which greatly improves VA L I D AT I O N turn-around-time, and an ashing accessory which converts the digestion system into a microwave muffle. P A C K A G E Compliance with regulations and data traceability requirements are paramount in the modern analytical lab, such as MMR-15 pharmaceutical, nutraceutical or other Evaporation/Concentration rotor regulated industries. Milestone’s operating software, easyCONTROL, is fully compliant with FDA regulation 21 CFR part 11. The Milestone Validation Package gives access to our factory trained engineers and specialists during the qualification process, enabling a fast implementation of the ETHOS UP in full accordance with Good Manufacturing Practice (GMP) guidelines. The comprehensive Milestone Validation Package (MVP) assures the complete qualification of the instrumentation. Different validation packages are available based on your specific needs: DQ (Design Qualification), IQ (Installation Qualification), OQ (Operational Qualification), PQ (Performance Qualification) and re-qualification. ultraFAST High-temperature muffle furnace (up to 1200°C) MILESTONE Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China, HELPING CHEMISTS Japan and Korea. We operate worldwide through a network of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible. ADDITIONAL MILESTONE SOLUTIONS FOR ELEMENTAL ANALYSIS ultraWAVE duoPUR/subCLEAN traceCLEAN DMA-80 The Game Changer in Acid Purification Acid Steam Direct Mercury Analyzer Microwave Digestion System Cleaning System WWW.MILESTONESRL.COM MILESTONE MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - Italy Tel: +39 035 573857 - Fax: +39 035 575498 www.milestonesrl.com - email: analytical@milestonesrl.com MILESTONE INC. - 25 Controls Drive - Shelton, CT 06484 - USA Tel: (203) 925-4240 - Toll-free: (866) 995-5100 - Fax: (203) 925-4241 www.milestonesci.com - email: mwave@milestonesci.com H E L P I N G C H E M I S T S MILESTONE GENERAL K.K. - KSP, 3-2-1, Sakado - Takatsu-Ku, Kawasaki 213-0012 - Japan - Tel: +81 (0)44 850 3811 - Fax: +81 (0)44 819 3036 UNI EN ISO 9001: 2008 www.milestone-general.com - email: info@milestone-general.com CERTIFIED MLS GmbH - Auenweg 37 D-88299 Leutkirch im Allgau - Germany Tel: +49 (0)7561 9818-0 - Fax: +49 (0)7561 9818-12 T354EN-005 • 2019-11 www.mls-mikrowellen.de - email: mws@mls-mikrowellen.de CA