DT Online System Semi-automatic dissolution testing with integrated UV-Vis analysis NEW The highlights of the new DT Online System The ERWEKA Dissolution Online Systems are the perfect, semi-automatic solution for dissolution testing with integrated UV-Vis online analysis. The DT 720 with integrated, automatic Sampling station ASS-8 transports freshly taken samples directly to the UV-Vis analysis. The samples are analyzed directly and the data is evaluated and saved using our advanced Disso.NET software. With the help of the Thermo ScientificTM Evolution 350TM Double-Beam Spectrophotometer that we recommend and which is fully integrated into the system, 5-minute cycles in the 200 nm to 350 nm range, which is important for dissolution tests, can be tested and evaluated with high efficiency. In connection with the maintenance-free pump PVP 820, the customer can trust on highest re-liabilityin dissolution testing. 100% USP/EP compliant dissolution testing USP Method 1, 2, 5 and 6 Thermo ScientificTM Evolution 350TM Spectrophotometer for 5-min. cycles Completely software controlled by Disso.NET 2 Dissolution Tester DT 728 The ERWEKA DT 728 is the perfect dissolution tester for the ERWEKA DT online system. The DT 728 ensures absolutely reliable test results that the user can rely on. 100% USP/EP compliant, in the usual robust ERWEKA quality and with integrated automatic sampling station ASS-8 and automatic tablet drop. High-precision pumping with the PVP 820 With the maintenance-free PVP 820 piston pump, the samples are transported precisely from the dissolution tester to the Thermo Scientific Evolution 350 Photometer. Complete control with Disso.NET The Windows software Disso.NET completely controls the entire dissolution system, manages methods with tests and generates the associated reports. The software tracks all changes that are made using the integrated 21 CFR part 11 compliant audit trail. Thanks to the full integration of the Thermo Scientific Evolution 350, the UV-Vis evaluation takes place directly in the Disso.NET - so the user has all the data of the dissolution test in one place. Thermo ScientificTM Evolution 350TM The Evolution 350TM is a double-beam photometer with xenon flash from Thermo Scientific. It is completely USP/EP compliant, offers selectable ban width (0.5 - 4.0 nm) and enables 5-minute cycles with spectra be-tween 200 nm and 350 nm. It is completely integrated in the Disso.NET from hardware conrol up to data evaluation. NEW 3 DT Online System Highlights 100% USP/EP-compliant Dissolution Tester DT 720 The ERWEKA DT 720 series was developed in accordance with 100% USP/EP the USP/EP/JP requirements for testing tablets and other dosage compliant dissolution forms. It combines the latest technology with excellent and user-fri-testing endly design. The drive head can be operated both in the high-head and in the low-head position and thus offers maximum flexibility. As USP method 1, 2, 5 part of the Dissolution Online System, it is completely controlled and 6 by the connected Disso.NET software - from the automatic tablet drop, to the control of the motors and the retraction and extension of the automatic sampling station ASS-8. External heater for vibration free testing The manual drive head with gas spring support enables simple and quick lifting within a few seconds. Evaporation is less than one percent within 24 hours (37 ° C, 50 rpm, 1000 ml). Thanks to its new, long-lasting plastic housing, corrosion is reduced to a mini-mum. The DT 720 is therefore an extremely reliable partner for daily dissolution test tasks. 4 Reliable double-beam photometer Thermo ScientificTM Evolution 350TM The Thermo ScientificTM Evolution 350TM is a robust and precise 100% USP/EP double-beam photometer with xenon flash. With its performance compliant optimized for demanding applications and selectable band widths of 0.5, 1.0, 1.5, 2.0 and 4.0 nm, it is ideally adapted to the diverse requirements of a dissolution system. The xenon flash is extremly Double-beam xenon durable (>3 years) and is available within seconds - this eliminates flash long warm-up times and measurement operation can be started quickly. In combination with our dissolution tester, the Evolution 350 also enables 5-minute cycles without any problems. 5-minute cycles up to 350 nm With the ERWEKA Disso.NET, the Evolution 350 is seamlessly integrated into all ERWEKA dissolution systems either online, online/ offline or the RoboDis II with up to 40 batches. This enables com-Full integration in bined reports with detailed dissolution curves and, if necessary, the Disso.NET software recalculation of the test data. ■ Double-beam xenon flash ■ 5-minute cycles with spectra from 200 nm to 350 nm ■ 100% USP/EP compliant ■ Seamless integration in ERWEKA Disso.NET dissolution software ■ Selectable gap widths (0.5, 1.0, 1.5, 2.0 and 4.0) 5 DT Online System DT 720 & Thermo Scientific Evolution 350 ERWEKA Systems Versatile configurations ERWEKA dissolution systems can be configured in many ways and Can be flexibly can be adapted to customer requirements and budgets. In additi-adapted to customer on to the recommended configuration with the perfectly integrated requirements Thermo Scientific Evolution 350 and the maintenance-free piston pump PVP 820, there are variants with the cheaper peristaltic pump Dissolution testing IPC 8 and the Shimadzu UV-1900 photometer. with up to 14 digits If the test volume is high, we also offer a DT Online System with a 14-Vessel DT 141x and the Analytic Jena Specord 210/16. Full integration of all system components in Disso.NET software Art. No. Dissolution Online System UV-Vis 26932 UV-Vis Online System with Evolution 350, IPC 8 for DT 72x + Disso.NET 4 27028 UV-Vis Online System Analytic Jena Specord 210, IPC16 for DT 141x/DT 161x 27030 UV-Vis Online System with Shimadzu 1900, IPC 8 for DT 72x + Disso.NET 4 26934 UV-Vis Online System with Evolution 350, PVP 820 for DT 72x + Disso.NET 4 26983 UV-Vis Online System Analytic J. Specord 210, PVP 1420 for DT 141x/DT 161x 27031 UV-Vis Online System with Shimadzu 1900, PVP 820 for DT 72x + Disso.NET 4 High volume testing with DT 141x and Analytic Jena Specord 210/16 6 Technical specifications Thermo ScientificTM Evolution 350TM Modified Ebert Optical Design Double beam with sample and reference cuvette/accessory positions Spectral Bandwidths Selectable 0.5, 1.0, 1.5, 2.0, 4.0 nm Light source Xenon flash lamp Detector Detector dual-matched silicon photodiodes Grating Holographic, 1200 lines/mm, blazed at 240 nm Beam Separation 210 mm Absorbance, % Transmittance, % Reflectance, Kubelka-Munk, Scan Ordinate Modes Log(1/R), Log(Abs), ABS × Factor, Intensity, 1st–4th Derivative Range 190–1100 nm Accuracy ±0.20 nm (546.07 nm Hg emission linie), ±0.30 nm, 190–900 nm Wavelength Repeatability Standard deviation for 10 measurements <0.05 nm Scanning speeds Variabel, up to 6000 nm/min Data interval 10, 5, 2, 1, 0.5, 0.2, 0.1, 0.05 nm Range >4 A Accuracy - Photometric 1A: ±0.004 A – 2A: ±0.004 A – 3A: ±0.006 A Instrument* Repeatability 1A: ±0.0025 A Stray light 198 nm: 2.4 A KCl – 220 nm: 3.5 A NaI – 340 nm: 4.0 A NaNO2 Baseline Flatness ±0.0015 A (200–800 nm) – 2.0 nm SBW, smoothed Dimensions (W × D × H) 61 × 53 × 38 cm Weight 22 kg Electrical Supply 100–240 V, 50–60 Hz Data according to the manufacturer, subject to change. 7 DT Online System System Variants & Technical Data Technical data DT 720 series USP Method 1 (Basket), Method 2 (Paddle), Method 5 (Paddle-over-Supported USP methods disk), Method 6 (Rotating Cylinder) with 6 or 8 test stations USP/EP/JP compliance 100% FDA Mechanical Calibration check Manually via LED display and membrane keys on the device, Device control 100% controllable via Disso.NET software Evaporation <1% (measured at 50 RPM, 1000 ml, 37 ° C over 24 h) Vessel centerig Automatic centering rings External heating with a heating range of 30 - 50 ° C; Heater minimizes vibrations Manual tablet insertion or optional automatic tablet Tablet insertion insertion (controllable via Disso.NET) Leveling Adjustable feet for quick leveling RS 232 interface for PC connection, USB-B interface Connections for firmware updates, USB-A for printers Dimensions (HxWxD) 940 mm x 830 mm (with heater) x 640 mm Weight 47 kg Power connection 115 V or 230 V, 50/60 Hz Technical data PVP x20 Pump PVP 620/720/820 PVP 1220/1420 Channels 6, 7 or 8 12 or 14 Valves - Accuracy +/- 0,5 m. System compatibility DT Online System, DT Offline System, DT On-/Offline System Filtration down to 0.22 μm with a flat membrane filtration. Benefits Particularly suitable for fully automatic dissolution systems. Dimensions (HxWxD) 420x280x475 420x275x575 Weight 21 kg 28 kg Power connection 115 V or 230 V, 50/60 Hz ERWEKA GmbH Pittlerstr. 45 E-Mail: sales@erweka.com Product specifications are subject to change and 63225 Langen Telefon: +49 6103 92426-200 are subject to change without notice. v.1.2.4.20 Deutschland Fax: +49 6103 92426-999