KNAUER OEM. The Original. LIQUID CHROMATOGRAPHY SYSTEMS AND MODULES HIGH PRESSURE DOSING PUMPS LC DETECTORS MANUAL INJECTION AND AUTOSAMPLERS HPLC VALVES SOFTWARE Your innovative solution. Made in Germany since 1962. NOTES KNAUER Independent and family-owned THE ORIGINAL KNAUER is an independent, family owned, middle-sized company with • Own hardware and software development • Process-controlled development and manufacturing • Dedicated OEM team to serve customers • Development and manufacturing in Germany CEO and owner Alexandra Knauer KNAUER was one of the first companies in Ger-As a producer of HPLC systems, KNAUER is many to develop devices for analytical liquid the right partner for development and supply chromatography. With tremendous experience around all liquid chromatography fields. We on how to make successful instrumentation, we develop innovative and individual solutions are active in this field for decades. In addition according to your specification. to manufacturing our own brand, we also offer contract manufacturing and development. The We are The Original. company, with its advanced quality and environmental management, offers a comprehensive For more information: www.knauer.net/oem range of products for high-performance liquid chromatography. KNAUER Mechanical Shop in Berlin, Germany © KNAUER Wissenschaftliche Geräte GmbH • oem@knauer.net • +49 30 809727-300 • www.knauer.net/oem 3 KNAUER OEM. THE ORIGINAL HOW TO GET YOUR INNOVATIVE SOLUTION Different industries and users need tailor-made solutions: DESIGN We develop products together with you to perfectly meet your customer‘s requirements. Customizing and optimizing the look of the product page 30 DEFINE Determining technical and functional requirements page 6, 16, 24, 18 MARKET LAUNCH Serial production and training CONFIGURE page 33 Putting together the right modules VERIFICATION page 12, 20, 26 Testing and approval page 32 WHO WE ARE 4 www.knauer.net/oem 5 DEFINE PUMP SPECIFICATIONS All KNAUER pumps Pump head max. flow rate (ml/min) 5,10,50,100,250,500,1 000 Piston seal washing Passive (compact pumps), active (all other pumps) DEFINE YOUR HIGH PRESSURE PUMP Wetted materials Aluminum oxide/Zirconium oxide, PEEK/PCTFE, Graphite Fiber, Reinforced PTFE, FKM/FFKM, Ruby, Titanium, Stainless steel Dosing and feed pumps, analytical and preparative LC pumps Optional modules Solvent selection valve: 3/2 solenoid valve, 24V; Base: PEEK; Seals: FFKM, 8.7 x 37 x 68.8 mm (WxDxL); Degasser: 2 & 4 channels, internal volume per chamber 285 μl; LPG valve: 2/2 known for their reliability and versatility valve, FFPM, 24 Static mixer volume (μl) 50, 100, 200, 250 (Microfluidic mixing technology) Dynamic mixer (ml) 1 740, 5.9 (using magnetic stirrer) Control LAN, RS-232, USB, Analog, Stand-alone, Mobile control Supported by ClarityChrom®, PurityChrom®, OpenLab CDS EZChrom Edition, Chromeleon™ Knauer Service tool Available for all products Operation temperature 4 - 40°C , Air humidity below 90%, non-condensing Required ventilation power* 0.5W, 40x40 mm (x1) for small (S) pumps / 1W, 60x60 mm (x2) for large (L) pumps Supplements User & Service manuals, Service notes, Service SOPs & videos, Device & Service, communication protocol High pressure LC pumps Pump type Analytical & Preparative Delivery system Dual-piston with main and auxiliary pistons (analytical and semi-preparative) Dual-piston with two main pistons (preparative) Flow rate range (ml/min) 0.01 – 1 000 Flow rate accuracy (%) ±1 (compact high pressure pump with pressure sensor & high pressure analytical version) LAB-SCALE PUMPS FOR DOSING AND LC APPLICATIONS ±5 (compact high pressure pump w/o pressure sensor) ±2 (high pressure preparative version) KNAUER offers a wide range and fully-featured completely stainless steel free pumps, as well as Flow rate precision (%) ≤0.5 RSD (compact high pressure pump with and w/o pressure sensor) portfolio of metering pumps. (U)HPLC pumps are FPLC pumps. Interchangeable pump heads ensure <0.1 RSD (high pressure analytical and preparative versions) available for a wide range of analytical and pre-good adaptability and easy maintenance. Models Pressure range (bar) Up to 650 parative applications. For ion chromatography and equipped with electronic drive compensation have Temperature range (°C) -10 – 120 other bioinert applications, we are able to offer very low pulsation. Viscosity of liquids (mPa·s) Up to 1 000 High-pressure dosing pumps Pump type Dosing Delivery system Dual-piston with main and auxiliary pistons (for flow rates up to 50 ml/min) Dual-piston with two main pistons (for flow rate range 502.0 AU @270 nm (1,2), >2.2 AU @270 nm (3), >2.0 AU @274 nm (4,5) , >2.5 AU @274 nm (6) Biocompatible version all A4045 3 2 30 50 Control LAN, RS-232, Analog, Stand-alone, Mobile control A4042 3 2 300 50 Supported by OpenLab® EZChrom, ClarityChrom®, PurityChrom®, Chromeleon® A4061XB 10 10 300 20 KNAUER Service tool Available for all products A4061V2 10 10 300 20 Operation temperature (°C) 4–40 AMB18 3 2 300 100 1/16“ Required ventilation power* 0.5W, 40x40 ( x1)(1), 1W, 60x60(x1) (2,3), 1.9W, 60x60(x1)(4,5,6) AMC19XA 10 2 50 5 Supplements User & Service manuals, Service notes, Service SOPs & videos, Device & Service communication protocol AMC38 10 10 300 20 AMD59XA 50 6 50 5 Refractive Index Detectors (Analytical/Preparative) A4044 3 2 300 50 Light source Long-life LED A4089 0.5 3 200 250 Linearity (µRIU) >1000 (analytical) / >4000 (preparative) A4096 0.5 3 100 250 Flow cell volume (µl) 15 (analytical) / 9 (preparative) A4047 3 2 30 50 Max. flow rate (ml/min) 10 (analytical) / 100 (preparative) A4074 10 10 300 20 Control LAN, RS-232, Analog, Stand-alone, Mobile control A4066 0.5-1.25-2 1.7-4.3-6.8 200 1000 Supported by OpenLab® EZChrom, ClarityChrom®, PurityChrom®, Chromeleon® A4067 0.5-1.25-2 1.7-4.3-6.8 100 1000 KNAUER Service tool Available for all products 1/8“ A4078 0.5-1.25-2 1.7-4.3-6.8 200 1000 Operation temperature (°C) 4–40 A4079 0.5-1.25-2 1.7-4.3-6.8 100 1000 Supplements User & Service manuals, Service notes, Service SOPs & videos, Device & Service communication protocol A4081 0.5-1.25-2 1.7-4.3-6.8 200 10000 A4068 0.5-1.25-2 1.7-4.3-6.8 200 10000 1/4“ A4068-2 0.5-1.25-2 1.7-4.3-6.8 200 10000 A4152 0.5-1.25-2 - 80 >10000 AZURA® RID 2.1L OEM Kit Designed for OEM integration and business A4152-1 7 - 10 >10000 A4154 0.5-1.25-2 - 80 >10000 other A4154-1 10 - 10 >10000 1) UVD 2.1S/10D Variable single WL 2) UVD2.1L/40D Variable single WL A4155 0.5-1.25-2 - 80 >10000 3) 50D Variable multi WL 4) MWD 2.1L Variable multi WL 5) DAD 2.1L Diode array (265 diodes) 6) DAD 6.1L Diode array (1024 diodes) A4153 0.5-1.25-2 - 80 >10000 * Ventilator is described with frame size (mm) and required quantity for KNAUER original modules. 18 www.knauer.net/oem 19 CONFIGURE DETECTOR CONFIGURE YOUR DETECTOR From single wavelength to multi-wavelength to DAD COMPACT VARIABLE SINGLE 129 mm UV-VIS SINGLE/MULTI WAVELENGTH DETECTOR WAVELENGTH DETECTORS 169 mm Normal and fiber optic, stand-alone Normal and fiber optic, stand-alone and integrated and integrated versions available versions available 187 mm 121 mm 399 mm 242 mm 110 mm 100 mm 100 mm 129 mm 187 mm 60 mm 150 mm 190 mm 160 mm 210 mm 160 mm 121 mm 50 mm Kits integrable in a system Single wavelength detector kit Multi wavelength detector kit The mainboard can also be configured in horizontal position. Excluding electronics Excluding electronics 20 www.knauer.net/oem 21 CONFIGURE DETECTOR CONFIGURE YOUR DETECTOR DETECTOR CONFIGURATOR TYPE FLOW CELL FIRMWARE FLOW CELL MATERIAL TYPE UV/Vis single WL Stainless steel KNAUER Original Normal 208 mm UV/Vis multi WL Metal free Customized Fiber optic HIGH-END LC DETECTORS L-size housing Diode array Analytical detector Preparative Refractive index 523 mm 361 mm detector INTEGRATED IN SYSTEM Yes No 100 mm 120 mm 300 mm 300 mm 300 mm 300 mm TYPE OF REQUIRED CERTIFICATE ............................................................................................................... DAD/MWD 2.1L kit DAD 6.1L kit w/o electronics w/o electronics KNAUER supports OEM kits with technical documentation for different types of certifications such as CE and CSA/UL. 129 mm 100 mm 180 mm 200 mm 190 mm 160 mm UVD 2.1L kit RID 2.1L kit w/o electronics w/o electronics 22 www.knauer.net/oem 23 DEFINE VALVES SPECIFICATIONS KNAUER Valves DEFINE YOUR SWITCHING SOLUTION Valve scale Analytical, Preparative Valve function Injection, column selection, fraction collection, other switching tasks Valves & valve drive for multiple applications Max pressure (bar) 25 KNAUER valves are designed for a wide range of chromatographic and dosing applications. Flexibility is provided by choice of different materials Max pressure (psi) 363- 17405 and sizes as well as drivers for various software packages. Valves are Bore size (mm) 0.3- 2.0 driven either manually or automatically through an electric valve drive. Capillary connection (inch) 1/16” Stator material Stainless steel, Stainless steel DLC, PEEK Rotor material Vespel, PEEK, PPS, POM 5x storage loop A1 A2 waste B1 B2 UV Con back detector pressure fraction collector regulator Since KNAUER controls the entire production which features automatic valve head recognition pump pump chain from development to production, valves and adjusts torque and switching speed specifi-A B reinjection AUTOMATION can also be produced to meet the customized cally for each valve head. Therefore, only one sample pump specification. The Valve Unifier is a smart valve valve drive is needed regardless of the valve head drive with various control options (LAN, USB, an-design from analytical to preparative scale and alog, CAN and RS-232) and RFID technology this makes your logistics very cost-effective. storage loop 5x A1 A2 storage loop 5x waste B1 B2 A1 A2 waste B1 B2 UV Con back UV Con detector pressure fraction collector regulator back pump pump detector pressure fraction collector sample A B reinjection AUTOMATION regulator pump pump pump sample A B reinjection pump AUTOMATION 24 www.knauer.net/oem 25 CONFIGURE VALVES VALVE CONFIGURATOR CONFIGURE YOUR VALVE DRIVE TYPE FUNCTION STATOR MATERIAL ROTOR MATERIAL The compact design of the valve drive makes it Manual Column selection Stainless steel Vespel flexible and easy for system integration Automated Injection Stainless steel DLC PEEK Fraction collection PEEK PTFE PPS-HPV POM-H-TF MAX. PRESSURE CAPILLARY CONNECTION (bar / psi) (inch) 123 mm 25 / 363 240 / 3480 1/16” Valve drive w/o display & keypad 50 / 725 300 / 4350 1/8” 150 / 2176 400 / 5802 1/4 “ 192 mm 200 / 2900 1200 / 17405 80 mm TYPE OF REQUIRED CERTIFICATE ............................................................................................................... KNAUER supports OEM kits with technical 111 mm documentation for different types of certifications such as CE and CSA/UL. Valve drive with motor circuit and interface boards 192 mm 67 mm 93 mm Integrated valve drive Integrated valve drive Valve drive with motor circuit board 180 mm 54 mm S Standalone valve drive tand-alone valve drive 26 www.knauer.net/oem 27 DEFINE SOFTWARE CHOOSE YOUR SOFTWARE DRIVERS MOBILE CONTROL Intuitive software for tablets, laptops and desktop PCs Multiple software drivers and established service software Due to our modular OEM platform, KNAUER offers you driver for various chromatography data systems. In case that you would like to use your own software application, KNAUER will provide you with all necessary communication protocols. • Mobile Control (Chrom) • OpenLAB® CDS EZChrom Edition • ClarityChrom® CDS • PurityChrom® • Chromeleon™ 7.2 Drivers For selected devices we offer support for even more CDS in the market such as ... Mobile Control is the right solution for you if you Save time • PrepCon need a basic, easy to use and cost-effective soft-Mobile Control convinces due to an intuitive user • Chromstar 7 ware for your LC system OR you would like to con-interface and a clearly structured menu function. • HyStar trol your devices without doing LC. The training period is minimal in comparison to a complex CDS. Especially users with little experi-Only pay for what you use ence in LC will easily get familiar with the software. To provide the most useful tools for your daily work, our team of software engineers combines its Mobile Control features basic functions to operate expertise in developing firmware, instrument control drivers, as well as application software. AZURA devices and systems. Mobile Control can Save space operate dedicated applications which do not re-Mobile Control runs on a tablet. Especially in labs • KNAUER Service Tool quire a highly developed and cost-intensive Chro-with little space avoiding a desktop PC with key-Available for a wide range of OEM products for different reasons like monitoring, adjusting, matographic Data System (CDS). board and monitor can be a decisive factor. The calibrating, diagnostic and software upgrade touch-optimized user interface allows device con-Customized software design trol using just your fingers. Mobile Control is made by KNAUER and can be adapted to the requirements of our OEM partners. Find detailed information: www.knauer.net/mobilecontrol 28 www.knauer.net/oem 29 DESIGN KNAUER OEM DESIGN YOUR PRODUCT Would you like to have your own exterior design which fits your PRODUCT DESIGN CONFIGURATOR other products and company pattern? We provide all the required Start designing your OEM system with our configurator CAD files and work on them together with you to achieve the best solution. HOUSING FRONTING LABELING KNAUER Original KNAUER OEM Via KNAUER Your label Customized Customized Private Label As kit Your housing Your color Your fronting YOUR INDIVIDUAL BRANDING Design your own front cover and present your own unique system. Most of our OEM partners are interested in a front cover that is • lightweight • neutral • printable and color customizable with logos and scripts DESIGN EXAMPLE Dynamic Biosensors, Germany Protein purification system proFIRE® 30 www.knauer.net/oem 31 OEM ACCESSORIES: CAPILLARIES CERTIFICATIONS K-CONNECT CAPILLARIES QUALITY MANAGEMENT Perfectly suited for all analytical HPLC systems: The KNAUER quality management system ket. Therefore, we can only be successful if every K-Connect Start-Up Kits contain flexible, precut ID (mm) according to DIN EN ISO 9001 makes sure that we employee contributes his share. Your satisfaction stainless steel capillaries with 1/16” sleeves at the 0.1, 0.18, 0.45 continuously manufacture products in the best with the quality of our products and services is end for easy installation in several inner diameters quality possible. As a company, we have to prove the key to our success. and lengths as well as adaptors and connectors. ourselves every day in a highly competitive mar-The precut capillary with ideal offered lengths, Length (mm) minimizes the system dead volume and eliminates 150, 300, 400, 700, 900 errors by poorly cut ones. ENVIRONMENTAL MANAGEMENT KNAUER contributes to the conservation of a minimal downtime. Furthermore, a high energy Fingertight up to healthy environment by basing our work on an efficiency and material efficiency in the produc-700 bar Adjusts on any environmental management system according tion process and during the use of our products column port to DIN EN ISO 14001. Starting with the develop-are important to us. Finally, the products should ment of a new product, our designing engi-be able to be disposed of in an environmentally neers are bound to use long-lasting materials compatible way. which allow low maintenance time intervalls and UNF 10/32 threads Fit on any fit in any standard Optional: capillary with HPLC port wrench-tight up 1/16“ OD to 1200 bar STANDARD CAPILLARIES Knauer can provide you the standard capillaries in stainless steel and PEEK material in different ID, OD, and lengths. Does your application require other ID & OD than available options? Do you need capillaries to be delivered in special form and packing? Contact the KNAUER OEM team! Stainless steel PEEK ID (mm) OD ID (mm) OD 0.1, 0.25, 0.5, 0.7, 1.0 1/16 “ 0.13, 0.18, 0.25, 0.5, 0.75, 1.0, 1.4 1/16” 1.6, 2.2 1/8” 0.75, 1.59, 2.0 1/8” 4.6 1/4” Find detailed information in the KNAUER Product Selection Guide. www.knauer.net 32 www.knauer.net/oem 33 VERIFY YOUR PRODUCT LET’S LAUNCH TOGETHER The demand for your product Your solution. Now. Verification is an essential step to apply in order to ensure the agreed quality, we coordinate all to satisfy the customer and to deliver a product system tests, which the manufactured products that matches the industry quality standards. We must go through in our company after produc-check that the product we are building matches tion, with our customers. We deliver the desired the users and business needs. The biggest chal-test certificates in customer design to ensure that lenge within a hardware and software project is the customer‘s incoming good inspections can to be in time, in quality and in budget. In order be reduced to a minimum. Thomas Müller, Head of Production in the Mechanical Shop Fulfilling a mission requires team work, long-term Whatever your plans are, adding your own LC partnership and collaboration. We are proud to system to your analysis instruments or choose have business partners all over the world by from one of our state of-the-art modules or ac-integrating our technology into their business cessories. You will find a good selection fulfilling needs. various needs. Verification in the KNAUER lab GET IN TOUCH oem@knauer.net www.knauer.net/oem 34 www.knauer.net/oem 35 Technical data or prices are subject to change without All trademarks are the property of their respective owners. notice. Prices may vary by country and do not include Our general terms and conditions apply: taxes, customs duties or delivery. www.knauer.net/terms UER 2019/V7712US/1.0/10.19 © KNA KNAUER +49 30 809727-0 Wissenschaftliche Geräte GmbH +49 30 8015010 (Fax) Hegauer Weg 38 oem@knauer.net 14163 Berlin, Germany www.knauer.net/oem