Water Content Analysis Karl Fischer titration and Near-Infrared Spectroscopy in perfect synergy Karl Fischer titration in the lab - Near infrared spectroscopy in the process 02 Metrohm offers the unique combination of high-precision laboratory analysis and inline spectroscopic analysis methods. This results in a powerful duo for water determination in low concentrations directly in your process, to improve product quality and increase savings. Innovation know-how for over 50 years Safe and economical process control Metrohm relies on many years of know-how in the areas Near-infrared spectroscopy (NIRS) is ideal for continuous of Karl Fischer (KF) titration and is recognized as the process monitoring. Without sampling or using global market leader in this field. Karl Fischer titration is chemicals, analytical results are generated in near real-one of the most widely used analytical methods in time every second. The measurement itself takes place routine laboratory work and it provides precise analytical directly in the process line and the precision of the results for samples col ected in the process. To increase method (NIR) is always as good as its reference analysis sample throughput, productivity, and product quality; (KF). This is exactly where Metrohm brings added value water determination can be easily implemented inline, in and a high level of confidence, thanks to an the process, thanks to NIR spectroscopy. The results of unprecedented expertise on the lab analysis and the the laboratory analysis are directly used to create the process implementation. prediction model for the NIR spectrometer. The benefits for NIR spectroscopy in process Efficiency Quality l Reliable inline quality control l Accurate and precise analysis l Optimized process control LITY CONTROL method A through «real-time» analysis U Q l Minimize human error l Up to 9 independent l Early process deviations A sampling points with one PPROVED detection instrument Costs Time l Shorter production times l No sample preparations l Higher yields, less rework l Fast analysis results around l Low-maintenance analytics the clock (24/7) $ SAVE MONEY l Higher product quality l Fast ROI, in most cases l No reagent - No chemical < 3 months waste l Save on man hours l Reliability Robust process analyzers for in plant operation in hazardous environments with high uptimes l Added benefit Multiplexing capability of NIR systems: More savings per measurement point and results l Synergy Optimum inline application creation by using high-precision Karl Fischer titration as validation method l Sustainability Less use of utilities (steam, electricity,...) thanks to better process control. Less chemical waste thanks to the reduction of chemical use and sample volume in the laboratory Near-infrared spectroscopy from Metrohm - Pushing the limits together The method of choice Accurate analysis results 03 The NIRS XDS Process Analyzers from Metrohm transfer Only the high precision and availability of laboratory the determination of water content directly into the analysis and the support of Metrohm application process. The method does not replace laboratory analysis specialists make NIRS measurement possible even in the - it complements it to the extent that a continuous low concentration range of less than 10 mg/L (ppm). The monitoring of the process is enabled. Therefore, the deciding factor here is the optimal method creation. number of intermediate controls with Karl Fischer titration can be reduced. KF titrator - The primary analysis in the lab l Customized applications In routine laboratory work, the Karl Fischer titrator generates a multitude of results from samples col ected in the process. Meanwhile, spectra of those samples are recorded (offline or directly in the process) with the NIRS XDS Process Analyzer. Developing method l Linking of Laboratory and Process analytics To determine the water concentration, a robust calibration model is created. The spectra are now linked to the results of the primary analysis in the analysis software. This creates a linear relationship between laboratory and NIR values. The developed method is now ready for the process. NIR routine measurement in the process l Real-time analytics in the process Using optical fibers and immersion probes, the analyzer is connected to one or up to nine measuring points simultaneously in the process. The prediciton model is applied to each individual continuously recorded spectra and the analysis results are displayed in seconds. Reliable analysis results make your QA and QC more efficient and safer l Fully automated solution for your process A true added value for your process. The NIRS XDS Process Analyzer provides reliable water analysis results 24 hours a day, 365 days a year, directly to your PC or DCS. In addition, warning limits or intervention limits can be defined by the user. www.metrohm.com V. G, CH-9100 Herisau ohm Applikon B. ohm A a, Metreir 10 err ea F witzerland by Metr Subject to change without prior notice Layout by Andr Printed in S 8.000.5325EN – 2019-